| Full name: DIS3 like 3'-5' exoribonuclease 2 | Alias Symbol: FLJ36974|MGC42174 | ||
| Type: protein-coding gene | Cytoband: 2q37.1 | ||
| Entrez ID: 129563 | HGNC ID: HGNC:28648 | Ensembl Gene: ENSG00000144535 | OMIM ID: 614184 |
| Drug and gene relationship at DGIdb | |||
Expression of DIS3L2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DIS3L2 | 129563 | 238602_at | -0.1759 | 0.8107 | |
| GSE26886 | DIS3L2 | 129563 | 227597_at | -0.4555 | 0.0454 | |
| GSE45670 | DIS3L2 | 129563 | 227597_at | -0.1921 | 0.0858 | |
| GSE53622 | DIS3L2 | 129563 | 107495 | 0.1339 | 0.0580 | |
| GSE53624 | DIS3L2 | 129563 | 34657 | -0.6460 | 0.0000 | |
| GSE63941 | DIS3L2 | 129563 | 242539_at | 1.6079 | 0.0545 | |
| GSE77861 | DIS3L2 | 129563 | 227597_at | -0.0412 | 0.8019 | |
| GSE97050 | DIS3L2 | 129563 | A_33_P3270203 | 0.1679 | 0.3829 | |
| SRP007169 | DIS3L2 | 129563 | RNAseq | -1.4593 | 0.0000 | |
| SRP008496 | DIS3L2 | 129563 | RNAseq | -1.2636 | 0.0000 | |
| SRP064894 | DIS3L2 | 129563 | RNAseq | -0.5414 | 0.0005 | |
| SRP133303 | DIS3L2 | 129563 | RNAseq | -0.1148 | 0.2811 | |
| SRP159526 | DIS3L2 | 129563 | RNAseq | -0.1336 | 0.6060 | |
| SRP193095 | DIS3L2 | 129563 | RNAseq | -0.0023 | 0.9866 | |
| SRP219564 | DIS3L2 | 129563 | RNAseq | -0.4277 | 0.1253 | |
| TCGA | DIS3L2 | 129563 | RNAseq | -0.0219 | 0.6872 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by DIS3L2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DIS3L2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DIS3L2 | 129563 | 1 | 12 | 17 | |
| GSE20123 | DIS3L2 | 129563 | 1 | 12 | 17 | |
| GSE43470 | DIS3L2 | 129563 | 1 | 8 | 34 | |
| GSE46452 | DIS3L2 | 129563 | 0 | 5 | 54 | |
| GSE47630 | DIS3L2 | 129563 | 4 | 5 | 31 | |
| GSE54993 | DIS3L2 | 129563 | 2 | 2 | 66 | |
| GSE54994 | DIS3L2 | 129563 | 6 | 11 | 36 | |
| GSE60625 | DIS3L2 | 129563 | 0 | 3 | 8 | |
| GSE74703 | DIS3L2 | 129563 | 1 | 6 | 29 | |
| GSE74704 | DIS3L2 | 129563 | 1 | 5 | 14 | |
| TCGA | DIS3L2 | 129563 | 13 | 27 | 56 |
Total number of gains: 30; Total number of losses: 96; Total Number of normals: 362.
Somatic mutations of DIS3L2:
Generating mutation plots.
Highly correlated genes for DIS3L2:
Showing top 20/167 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DIS3L2 | AKAP8L | 0.743996 | 3 | 0 | 3 |
| DIS3L2 | ZNF394 | 0.729384 | 3 | 0 | 3 |
| DIS3L2 | GNB4 | 0.718785 | 3 | 0 | 3 |
| DIS3L2 | FASTKD1 | 0.717044 | 3 | 0 | 3 |
| DIS3L2 | CEP95 | 0.716377 | 4 | 0 | 4 |
| DIS3L2 | CRX | 0.713869 | 3 | 0 | 3 |
| DIS3L2 | LPIN3 | 0.710306 | 3 | 0 | 3 |
| DIS3L2 | RBM20 | 0.707547 | 3 | 0 | 3 |
| DIS3L2 | LUC7L3 | 0.701323 | 3 | 0 | 3 |
| DIS3L2 | CCDC84 | 0.698713 | 4 | 0 | 4 |
| DIS3L2 | C12orf66 | 0.692123 | 3 | 0 | 3 |
| DIS3L2 | ZNF782 | 0.687934 | 3 | 0 | 3 |
| DIS3L2 | DCAF8 | 0.687194 | 3 | 0 | 3 |
| DIS3L2 | STRN | 0.680186 | 5 | 0 | 5 |
| DIS3L2 | ATP1A3 | 0.678526 | 3 | 0 | 3 |
| DIS3L2 | GLIPR1L2 | 0.676391 | 3 | 0 | 3 |
| DIS3L2 | ZYG11B | 0.674983 | 3 | 0 | 3 |
| DIS3L2 | GGA3 | 0.66909 | 3 | 0 | 3 |
| DIS3L2 | HIC2 | 0.664744 | 3 | 0 | 3 |
| DIS3L2 | KLHL28 | 0.662607 | 4 | 0 | 3 |
For details and further investigation, click here
