| Full name: apolipoprotein B mRNA editing enzyme catalytic subunit 1 | Alias Symbol: BEDP|CDAR1|APOBEC-1|HEPR | ||
| Type: protein-coding gene | Cytoband: 12p13.31 | ||
| Entrez ID: 339 | HGNC ID: HGNC:604 | Ensembl Gene: ENSG00000111701 | OMIM ID: 600130 |
| Drug and gene relationship at DGIdb | |||
Expression of APOBEC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APOBEC1 | 339 | 207158_at | -0.2179 | 0.2155 | |
| GSE20347 | APOBEC1 | 339 | 207158_at | -0.0533 | 0.4542 | |
| GSE23400 | APOBEC1 | 339 | 207158_at | -0.0954 | 0.0047 | |
| GSE26886 | APOBEC1 | 339 | 207158_at | 0.0279 | 0.8526 | |
| GSE29001 | APOBEC1 | 339 | 207158_at | -0.0750 | 0.6588 | |
| GSE38129 | APOBEC1 | 339 | 207158_at | -0.0934 | 0.1987 | |
| GSE45670 | APOBEC1 | 339 | 207158_at | 0.1619 | 0.0433 | |
| GSE53622 | APOBEC1 | 339 | 90492 | -3.6552 | 0.0000 | |
| GSE53624 | APOBEC1 | 339 | 90492 | -4.1888 | 0.0000 | |
| GSE63941 | APOBEC1 | 339 | 207158_at | 0.2508 | 0.2611 | |
| GSE77861 | APOBEC1 | 339 | 207158_at | -0.1902 | 0.1574 | |
| TCGA | APOBEC1 | 339 | RNAseq | -4.4445 | 0.0024 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by APOBEC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APOBEC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APOBEC1 | 339 | 6 | 3 | 21 | |
| GSE20123 | APOBEC1 | 339 | 6 | 3 | 21 | |
| GSE43470 | APOBEC1 | 339 | 7 | 3 | 33 | |
| GSE46452 | APOBEC1 | 339 | 10 | 1 | 48 | |
| GSE47630 | APOBEC1 | 339 | 12 | 2 | 26 | |
| GSE54993 | APOBEC1 | 339 | 1 | 10 | 59 | |
| GSE54994 | APOBEC1 | 339 | 9 | 5 | 39 | |
| GSE60625 | APOBEC1 | 339 | 0 | 1 | 10 | |
| GSE74703 | APOBEC1 | 339 | 7 | 2 | 27 | |
| GSE74704 | APOBEC1 | 339 | 4 | 2 | 14 | |
| TCGA | APOBEC1 | 339 | 40 | 6 | 50 |
Total number of gains: 102; Total number of losses: 38; Total Number of normals: 348.
Somatic mutations of APOBEC1:
Generating mutation plots.
Highly correlated genes for APOBEC1:
Showing top 20/1226 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APOBEC1 | MALL | 0.859604 | 3 | 0 | 3 |
| APOBEC1 | CNFN | 0.84867 | 3 | 0 | 3 |
| APOBEC1 | RAB10 | 0.829304 | 3 | 0 | 3 |
| APOBEC1 | ARHGAP27 | 0.813974 | 3 | 0 | 3 |
| APOBEC1 | CD24 | 0.812404 | 3 | 0 | 3 |
| APOBEC1 | GRHL3 | 0.804567 | 3 | 0 | 3 |
| APOBEC1 | TMEM154 | 0.796449 | 3 | 0 | 3 |
| APOBEC1 | CXCL17 | 0.78767 | 3 | 0 | 3 |
| APOBEC1 | SPINK5 | 0.785815 | 4 | 0 | 4 |
| APOBEC1 | MGLL | 0.783708 | 4 | 0 | 4 |
| APOBEC1 | C15orf48 | 0.783669 | 3 | 0 | 3 |
| APOBEC1 | C1orf116 | 0.782581 | 3 | 0 | 3 |
| APOBEC1 | VSIG10L | 0.778255 | 4 | 0 | 4 |
| APOBEC1 | HS3ST6 | 0.775931 | 4 | 0 | 4 |
| APOBEC1 | SERPINB2 | 0.775263 | 3 | 0 | 3 |
| APOBEC1 | ZNF750 | 0.773723 | 3 | 0 | 3 |
| APOBEC1 | TOB1 | 0.76957 | 4 | 0 | 4 |
| APOBEC1 | ENDOU | 0.769027 | 4 | 0 | 4 |
| APOBEC1 | RAB27B | 0.768925 | 3 | 0 | 3 |
| APOBEC1 | SLCO4A1-AS1 | 0.768513 | 3 | 0 | 3 |
For details and further investigation, click here
