| Full name: cytoplasmic FMR1 interacting protein 2 | Alias Symbol: PIR121 | ||
| Type: protein-coding gene | Cytoband: 5q33.3 | ||
| Entrez ID: 26999 | HGNC ID: HGNC:13760 | Ensembl Gene: ENSG00000055163 | OMIM ID: 606323 |
| Drug and gene relationship at DGIdb | |||
CYFIP2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04810 | Regulation of actin cytoskeleton |
Expression of CYFIP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYFIP2 | 26999 | 215785_s_at | 0.1899 | 0.9035 | |
| GSE20347 | CYFIP2 | 26999 | 215785_s_at | -0.0504 | 0.8730 | |
| GSE23400 | CYFIP2 | 26999 | 220999_s_at | -0.2205 | 0.0000 | |
| GSE26886 | CYFIP2 | 26999 | 215785_s_at | 0.7458 | 0.0723 | |
| GSE29001 | CYFIP2 | 26999 | 220999_s_at | 0.0324 | 0.9017 | |
| GSE38129 | CYFIP2 | 26999 | 215785_s_at | -0.4872 | 0.1123 | |
| GSE45670 | CYFIP2 | 26999 | 215785_s_at | -0.4204 | 0.2425 | |
| GSE53622 | CYFIP2 | 26999 | 23105 | -0.5075 | 0.0000 | |
| GSE53624 | CYFIP2 | 26999 | 23105 | -0.7424 | 0.0000 | |
| GSE63941 | CYFIP2 | 26999 | 215785_s_at | -0.7604 | 0.4795 | |
| GSE77861 | CYFIP2 | 26999 | 215785_s_at | -0.0066 | 0.9748 | |
| GSE97050 | CYFIP2 | 26999 | A_33_P3226177 | 0.3547 | 0.3467 | |
| SRP007169 | CYFIP2 | 26999 | RNAseq | 0.2497 | 0.7408 | |
| SRP064894 | CYFIP2 | 26999 | RNAseq | 0.0308 | 0.9084 | |
| SRP133303 | CYFIP2 | 26999 | RNAseq | -0.5735 | 0.0440 | |
| SRP159526 | CYFIP2 | 26999 | RNAseq | -0.4200 | 0.5173 | |
| SRP193095 | CYFIP2 | 26999 | RNAseq | -0.5612 | 0.0199 | |
| TCGA | CYFIP2 | 26999 | RNAseq | -0.9039 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CYFIP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYFIP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYFIP2 | 26999 | 0 | 11 | 19 | |
| GSE20123 | CYFIP2 | 26999 | 0 | 11 | 19 | |
| GSE43470 | CYFIP2 | 26999 | 2 | 11 | 30 | |
| GSE46452 | CYFIP2 | 26999 | 0 | 27 | 32 | |
| GSE47630 | CYFIP2 | 26999 | 0 | 20 | 20 | |
| GSE54993 | CYFIP2 | 26999 | 9 | 1 | 60 | |
| GSE54994 | CYFIP2 | 26999 | 1 | 16 | 36 | |
| GSE60625 | CYFIP2 | 26999 | 0 | 0 | 11 | |
| GSE74703 | CYFIP2 | 26999 | 2 | 8 | 26 | |
| GSE74704 | CYFIP2 | 26999 | 0 | 6 | 14 | |
| TCGA | CYFIP2 | 26999 | 4 | 36 | 56 |
Total number of gains: 18; Total number of losses: 147; Total Number of normals: 323.
Somatic mutations of CYFIP2:
Generating mutation plots.
Highly correlated genes for CYFIP2:
Showing top 20/224 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYFIP2 | APOL3 | 0.73483 | 3 | 0 | 3 |
| CYFIP2 | RCSD1 | 0.731953 | 3 | 0 | 3 |
| CYFIP2 | ANKRD44 | 0.659317 | 4 | 0 | 3 |
| CYFIP2 | EOMES | 0.656623 | 3 | 0 | 3 |
| CYFIP2 | PLA2G4C | 0.648925 | 5 | 0 | 5 |
| CYFIP2 | WIPF1 | 0.647113 | 5 | 0 | 4 |
| CYFIP2 | TMEM163 | 0.645844 | 3 | 0 | 3 |
| CYFIP2 | PRKCB | 0.632507 | 6 | 0 | 5 |
| CYFIP2 | MYO1F | 0.629768 | 4 | 0 | 4 |
| CYFIP2 | GIMAP4 | 0.628636 | 6 | 0 | 5 |
| CYFIP2 | LINC00926 | 0.621282 | 3 | 0 | 3 |
| CYFIP2 | ZBBX | 0.61998 | 3 | 0 | 3 |
| CYFIP2 | AKNA | 0.619729 | 7 | 0 | 5 |
| CYFIP2 | MEF2C | 0.61949 | 5 | 0 | 4 |
| CYFIP2 | GIMAP6 | 0.619426 | 5 | 0 | 5 |
| CYFIP2 | APOBEC3G | 0.619052 | 5 | 0 | 4 |
| CYFIP2 | RPGRIP1 | 0.6157 | 3 | 0 | 3 |
| CYFIP2 | EVI2A | 0.613235 | 5 | 0 | 4 |
| CYFIP2 | TGM2 | 0.611242 | 3 | 0 | 3 |
| CYFIP2 | IL10RA | 0.608317 | 7 | 0 | 5 |
For details and further investigation, click here
