PLA2G4C

 

Full name: phospholipase A2 group IVC Alias Symbol: cPLA2-gamma
Type: protein-coding gene Cytoband: 19q13.33
Entrez ID: 8605 HGNC ID: HGNC:9037 Ensembl Gene: ENSG00000105499 OMIM ID: 603602
Drug and gene relationship at DGIdb

 

PLA2G4C involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04370VEGF signaling pathway
hsa04611Platelet activation
hsa04664Fc epsilon RI signaling pathway
hsa04724Glutamatergic synapse
hsa04726Serotonergic synapse
hsa04730Long-term depression
hsa04750Inflammatory mediator regulation of TRP channels
hsa04912GnRH signaling pathway
hsa04913Ovarian steroidogenesis
hsa04921Oxytocin signaling pathway
hsa05231Choline metabolism in cancer

 

Expression of PLA2G4C:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PLA2G4C 8605 209785_s_at -0.0351 0.9875
GSE20347 PLA2G4C 8605 209785_s_at 0.3020 0.2566
GSE23400 PLA2G4C 8605 209785_s_at -0.0789 0.4608
GSE26886 PLA2G4C 8605 209785_s_at 0.5466 0.3116
GSE29001 PLA2G4C 8605 209785_s_at 0.2663 0.4404
GSE38129 PLA2G4C 8605 209785_s_at -0.1367 0.6901
GSE45670 PLA2G4C 8605 209785_s_at -0.1707 0.7421
GSE53622 PLA2G4C 8605 137174 -0.2168 0.0816
GSE53624 PLA2G4C 8605 137174 -0.0682 0.5896
GSE63941 PLA2G4C 8605 209785_s_at -2.1592 0.0246
GSE77861 PLA2G4C 8605 209785_s_at 0.6295 0.0776
GSE97050 PLA2G4C 8605 A_23_P50508 0.0172 0.9648
SRP007169 PLA2G4C 8605 RNAseq 2.8500 0.0032
SRP064894 PLA2G4C 8605 RNAseq 0.9056 0.0073
SRP133303 PLA2G4C 8605 RNAseq 0.0161 0.9643
SRP193095 PLA2G4C 8605 RNAseq 1.3947 0.0000
SRP219564 PLA2G4C 8605 RNAseq -0.4788 0.5268
TCGA PLA2G4C 8605 RNAseq 0.0561 0.7882

Upregulated datasets: 2; Downregulated datasets: 1.  

 

Survival by PLA2G4C expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PLA2G4C:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PLA2G4C 8605 4 4 22
GSE20123 PLA2G4C 8605 4 3 23
GSE43470 PLA2G4C 8605 3 10 30
GSE46452 PLA2G4C 8605 45 1 13
GSE47630 PLA2G4C 8605 8 7 25
GSE54993 PLA2G4C 8605 17 4 49
GSE54994 PLA2G4C 8605 4 14 35
GSE60625 PLA2G4C 8605 9 0 2
GSE74703 PLA2G4C 8605 3 7 26
GSE74704 PLA2G4C 8605 4 1 15
TCGA PLA2G4C 8605 15 19 62

Total number of gains: 116; Total number of losses: 70; Total Number of normals: 302.  

 

Somatic mutations of PLA2G4C:

 

Generating mutation plots.

 

Highly correlated genes for PLA2G4C:

 

Showing top 20/500 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PLA2G4CGLI20.724464303
PLA2G4CDIRAS10.722141303
PLA2G4CSPSB10.660767303
PLA2G4CMYEF20.658844403
PLA2G4CCYFIP20.648925505
PLA2G4CDDX420.637744303
PLA2G4CFAP0.637234303
PLA2G4CRIMKLB0.635723403
PLA2G4CDMPK0.635325404
PLA2G4CTSC10.635171303
PLA2G4CPRRC2B0.630636404
PLA2G4CTFEB0.625594403
PLA2G4CSYNC0.622048403
PLA2G4CKCNJ80.6208891009
PLA2G4CCOPZ20.620744403
PLA2G4CASB20.619241403
PLA2G4CCAND20.618349706
PLA2G4CRASD20.615107504
PLA2G4CANXA60.6133921109
PLA2G4CPRKACA0.613184403

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