| Full name: apolipoprotein L3 | Alias Symbol: CG12-1|APOLIII | ||
| Type: protein-coding gene | Cytoband: 22q12.3 | ||
| Entrez ID: 80833 | HGNC ID: HGNC:14868 | Ensembl Gene: ENSG00000128284 | OMIM ID: 607253 |
| Drug and gene relationship at DGIdb | |||
Expression of APOL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APOL3 | 80833 | 221087_s_at | -0.3388 | 0.5706 | |
| GSE20347 | APOL3 | 80833 | 221087_s_at | -0.0497 | 0.8319 | |
| GSE23400 | APOL3 | 80833 | 221087_s_at | 0.0508 | 0.4947 | |
| GSE26886 | APOL3 | 80833 | 221087_s_at | -0.6548 | 0.1604 | |
| GSE29001 | APOL3 | 80833 | 221087_s_at | 0.6703 | 0.0428 | |
| GSE38129 | APOL3 | 80833 | 221087_s_at | -0.3343 | 0.0713 | |
| GSE45670 | APOL3 | 80833 | 221087_s_at | -0.0163 | 0.9738 | |
| GSE53622 | APOL3 | 80833 | 114981 | 0.7956 | 0.0000 | |
| GSE53624 | APOL3 | 80833 | 117025 | 0.7940 | 0.0000 | |
| GSE63941 | APOL3 | 80833 | 221087_s_at | -0.8928 | 0.2786 | |
| GSE77861 | APOL3 | 80833 | 221087_s_at | -0.2664 | 0.1469 | |
| GSE97050 | APOL3 | 80833 | A_24_P416997 | -0.1251 | 0.7642 | |
| SRP007169 | APOL3 | 80833 | RNAseq | 0.1178 | 0.8566 | |
| SRP064894 | APOL3 | 80833 | RNAseq | 0.1884 | 0.5301 | |
| SRP133303 | APOL3 | 80833 | RNAseq | -0.2160 | 0.5440 | |
| SRP159526 | APOL3 | 80833 | RNAseq | -0.7070 | 0.3157 | |
| SRP193095 | APOL3 | 80833 | RNAseq | 0.2841 | 0.1765 | |
| SRP219564 | APOL3 | 80833 | RNAseq | 1.0162 | 0.0160 | |
| TCGA | APOL3 | 80833 | RNAseq | 0.0032 | 0.9846 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by APOL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APOL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APOL3 | 80833 | 5 | 6 | 19 | |
| GSE20123 | APOL3 | 80833 | 5 | 5 | 20 | |
| GSE43470 | APOL3 | 80833 | 4 | 6 | 33 | |
| GSE46452 | APOL3 | 80833 | 31 | 1 | 27 | |
| GSE47630 | APOL3 | 80833 | 8 | 5 | 27 | |
| GSE54993 | APOL3 | 80833 | 3 | 6 | 61 | |
| GSE54994 | APOL3 | 80833 | 9 | 9 | 35 | |
| GSE60625 | APOL3 | 80833 | 5 | 0 | 6 | |
| GSE74703 | APOL3 | 80833 | 4 | 4 | 28 | |
| GSE74704 | APOL3 | 80833 | 2 | 2 | 16 | |
| TCGA | APOL3 | 80833 | 27 | 15 | 54 |
Total number of gains: 103; Total number of losses: 59; Total Number of normals: 326.
Somatic mutations of APOL3:
Generating mutation plots.
Highly correlated genes for APOL3:
Showing top 20/275 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APOL3 | KDM5D | 0.795846 | 3 | 0 | 3 |
| APOL3 | SOX18 | 0.739224 | 3 | 0 | 3 |
| APOL3 | CYFIP2 | 0.73483 | 3 | 0 | 3 |
| APOL3 | MAMDC4 | 0.724466 | 3 | 0 | 3 |
| APOL3 | PIK3R6 | 0.716287 | 3 | 0 | 3 |
| APOL3 | XRN1 | 0.71324 | 3 | 0 | 3 |
| APOL3 | NFATC2 | 0.70967 | 3 | 0 | 3 |
| APOL3 | EIF1AY | 0.703461 | 3 | 0 | 3 |
| APOL3 | SMARCA2 | 0.693395 | 3 | 0 | 3 |
| APOL3 | PIK3CB | 0.693029 | 3 | 0 | 3 |
| APOL3 | NUB1 | 0.692206 | 3 | 0 | 3 |
| APOL3 | RBM20 | 0.686517 | 3 | 0 | 3 |
| APOL3 | CR1L | 0.686164 | 3 | 0 | 3 |
| APOL3 | CELF6 | 0.678949 | 3 | 0 | 3 |
| APOL3 | CCND3 | 0.671105 | 4 | 0 | 3 |
| APOL3 | AFF3 | 0.667156 | 3 | 0 | 3 |
| APOL3 | PARP11 | 0.666928 | 3 | 0 | 3 |
| APOL3 | PSMB10 | 0.661614 | 9 | 0 | 8 |
| APOL3 | NLRP3 | 0.658535 | 4 | 0 | 3 |
| APOL3 | RWDD4 | 0.657997 | 3 | 0 | 3 |
For details and further investigation, click here
