GIMAP4

 

Full name: GTPase, IMAP family member 4 Alias Symbol: HIMAP4|FLJ11110|IMAP4|IAN1
Type: protein-coding gene Cytoband: 7q36.1
Entrez ID: 55303 HGNC ID: HGNC:21872 Ensembl Gene: ENSG00000133574 OMIM ID: 608087
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of GIMAP4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GIMAP4 55303 219243_at -0.1964 0.8532
GSE20347 GIMAP4 55303 219243_at -0.1597 0.3386
GSE23400 GIMAP4 55303 219243_at 0.0033 0.9606
GSE26886 GIMAP4 55303 219243_at -0.2465 0.2901
GSE29001 GIMAP4 55303 219243_at -0.0127 0.9773
GSE38129 GIMAP4 55303 219243_at -0.5496 0.0312
GSE45670 GIMAP4 55303 219243_at -1.0679 0.0075
GSE53622 GIMAP4 55303 134606 -0.5773 0.0000
GSE53624 GIMAP4 55303 134606 -0.5887 0.0002
GSE63941 GIMAP4 55303 219243_at 0.1982 0.2578
GSE77861 GIMAP4 55303 219243_at 0.0502 0.6960
GSE97050 GIMAP4 55303 A_24_P209455 0.2747 0.4336
SRP007169 GIMAP4 55303 RNAseq 0.8010 0.2070
SRP008496 GIMAP4 55303 RNAseq 0.5072 0.2138
SRP064894 GIMAP4 55303 RNAseq 0.3739 0.2290
SRP133303 GIMAP4 55303 RNAseq -0.3493 0.2093
SRP159526 GIMAP4 55303 RNAseq -0.2857 0.5924
SRP193095 GIMAP4 55303 RNAseq -0.0713 0.7377
SRP219564 GIMAP4 55303 RNAseq 0.3816 0.3089
TCGA GIMAP4 55303 RNAseq -0.2215 0.0644

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by GIMAP4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GIMAP4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GIMAP4 55303 2 4 24
GSE20123 GIMAP4 55303 2 4 24
GSE43470 GIMAP4 55303 2 5 36
GSE46452 GIMAP4 55303 7 2 50
GSE47630 GIMAP4 55303 6 8 26
GSE54993 GIMAP4 55303 3 3 64
GSE54994 GIMAP4 55303 6 8 39
GSE60625 GIMAP4 55303 0 0 11
GSE74703 GIMAP4 55303 2 4 30
GSE74704 GIMAP4 55303 1 4 15
TCGA GIMAP4 55303 26 27 43

Total number of gains: 57; Total number of losses: 69; Total Number of normals: 362.  

 

Somatic mutations of GIMAP4:

 

Generating mutation plots.

 

Highly correlated genes for GIMAP4:

 

Showing top 20/602 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GIMAP4GIMAP50.855026404
GIMAP4GIMAP60.84794811011
GIMAP4GIMAP80.847134707
GIMAP4MPEG10.831174606
GIMAP4ARHGAP150.826404404
GIMAP4FLI10.805581908
GIMAP4RCSD10.794166707
GIMAP4GIMAP70.787412807
GIMAP4C16orf540.777653606
GIMAP4PLEK0.757785404
GIMAP4IRF80.75049911011
GIMAP4EVI2A0.750125808
GIMAP4C1orf1620.737948707
GIMAP4GMFG0.73174411011
GIMAP4EBF10.730773505
GIMAP4GPR340.72953707
GIMAP4CR10.721836404
GIMAP4PHACTR10.721434404
GIMAP4TNFAIP8L20.719572605
GIMAP4MS4A70.71751404

For details and further investigation, click here