| Full name: NLR family pyrin domain containing 3 | Alias Symbol: AGTAVPRL|AII|AVP|FCAS|FCU|NALP3|PYPAF1|MWS|CLR1.1 | ||
| Type: protein-coding gene | Cytoband: 1q44 | ||
| Entrez ID: 114548 | HGNC ID: HGNC:16400 | Ensembl Gene: ENSG00000162711 | OMIM ID: 606416 |
| Drug and gene relationship at DGIdb | |||
NLRP3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04621 | NOD-like receptor signaling pathway | |
| hsa05133 | Pertussis | |
| hsa05164 | Influenza A |
Expression of NLRP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NLRP3 | 114548 | 207075_at | 0.3277 | 0.7008 | |
| GSE20347 | NLRP3 | 114548 | 207075_at | -0.0144 | 0.8694 | |
| GSE23400 | NLRP3 | 114548 | 207075_at | -0.0766 | 0.0344 | |
| GSE26886 | NLRP3 | 114548 | 207075_at | -0.4605 | 0.0211 | |
| GSE29001 | NLRP3 | 114548 | 207075_at | 0.0330 | 0.8903 | |
| GSE38129 | NLRP3 | 114548 | 207075_at | -0.1679 | 0.2559 | |
| GSE45670 | NLRP3 | 114548 | 207075_at | -0.3849 | 0.0371 | |
| GSE53622 | NLRP3 | 114548 | 106285 | -0.0137 | 0.9128 | |
| GSE53624 | NLRP3 | 114548 | 106285 | 0.0292 | 0.8416 | |
| GSE63941 | NLRP3 | 114548 | 216015_s_at | 0.0909 | 0.5249 | |
| GSE77861 | NLRP3 | 114548 | 207075_at | -0.0297 | 0.7606 | |
| GSE97050 | NLRP3 | 114548 | A_23_P9883 | 0.1359 | 0.5410 | |
| SRP007169 | NLRP3 | 114548 | RNAseq | 0.3962 | 0.6394 | |
| SRP064894 | NLRP3 | 114548 | RNAseq | 0.7774 | 0.0159 | |
| SRP133303 | NLRP3 | 114548 | RNAseq | 0.3683 | 0.2864 | |
| SRP159526 | NLRP3 | 114548 | RNAseq | 0.2665 | 0.7241 | |
| SRP193095 | NLRP3 | 114548 | RNAseq | 1.1485 | 0.0000 | |
| SRP219564 | NLRP3 | 114548 | RNAseq | 0.6299 | 0.4251 | |
| TCGA | NLRP3 | 114548 | RNAseq | -0.2065 | 0.3107 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by NLRP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NLRP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NLRP3 | 114548 | 7 | 1 | 22 | |
| GSE20123 | NLRP3 | 114548 | 7 | 1 | 22 | |
| GSE43470 | NLRP3 | 114548 | 4 | 3 | 36 | |
| GSE46452 | NLRP3 | 114548 | 4 | 2 | 53 | |
| GSE47630 | NLRP3 | 114548 | 15 | 1 | 24 | |
| GSE54993 | NLRP3 | 114548 | 0 | 6 | 64 | |
| GSE54994 | NLRP3 | 114548 | 18 | 0 | 35 | |
| GSE60625 | NLRP3 | 114548 | 0 | 0 | 11 | |
| GSE74703 | NLRP3 | 114548 | 4 | 1 | 31 | |
| GSE74704 | NLRP3 | 114548 | 2 | 0 | 18 | |
| TCGA | NLRP3 | 114548 | 45 | 4 | 47 |
Total number of gains: 106; Total number of losses: 19; Total Number of normals: 363.
Somatic mutations of NLRP3:
Generating mutation plots.
Highly correlated genes for NLRP3:
Showing top 20/373 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NLRP3 | SNX12 | 0.742092 | 3 | 0 | 3 |
| NLRP3 | SAMD3 | 0.741381 | 3 | 0 | 3 |
| NLRP3 | DDX19A | 0.717636 | 3 | 0 | 3 |
| NLRP3 | SEC22C | 0.716797 | 3 | 0 | 3 |
| NLRP3 | CYLD | 0.713169 | 4 | 0 | 4 |
| NLRP3 | TYW3 | 0.704722 | 3 | 0 | 3 |
| NLRP3 | MEX3B | 0.702537 | 4 | 0 | 3 |
| NLRP3 | GNGT2 | 0.701786 | 4 | 0 | 3 |
| NLRP3 | VCP | 0.700319 | 3 | 0 | 3 |
| NLRP3 | TSPAN9 | 0.689289 | 3 | 0 | 3 |
| NLRP3 | SUCNR1 | 0.686996 | 4 | 0 | 4 |
| NLRP3 | DAD1 | 0.68672 | 3 | 0 | 3 |
| NLRP3 | TDO2 | 0.685798 | 3 | 0 | 3 |
| NLRP3 | ADAMTS18 | 0.685355 | 3 | 0 | 3 |
| NLRP3 | LMAN1 | 0.683195 | 4 | 0 | 3 |
| NLRP3 | PGK1 | 0.681441 | 3 | 0 | 3 |
| NLRP3 | PRPF38A | 0.679987 | 3 | 0 | 3 |
| NLRP3 | PSME1 | 0.678249 | 3 | 0 | 3 |
| NLRP3 | HDAC3 | 0.678235 | 4 | 0 | 3 |
| NLRP3 | GDF6 | 0.675189 | 3 | 0 | 3 |
For details and further investigation, click here
