| Full name: differentially expressed in FDCP 8 homolog | Alias Symbol: FLJ20186 | ||
| Type: protein-coding gene | Cytoband: 16q24.3 | ||
| Entrez ID: 54849 | HGNC ID: HGNC:25969 | Ensembl Gene: ENSG00000140995 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of DEF8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DEF8 | 54849 | 225637_at | -0.3350 | 0.2708 | |
| GSE20347 | DEF8 | 54849 | 219646_at | -0.1531 | 0.4182 | |
| GSE23400 | DEF8 | 54849 | 219646_at | -0.3517 | 0.0000 | |
| GSE26886 | DEF8 | 54849 | 225637_at | -1.0242 | 0.0001 | |
| GSE29001 | DEF8 | 54849 | 219646_at | -0.5107 | 0.0215 | |
| GSE38129 | DEF8 | 54849 | 219646_at | -0.0139 | 0.9352 | |
| GSE45670 | DEF8 | 54849 | 225637_at | -0.2014 | 0.1882 | |
| GSE53622 | DEF8 | 54849 | 109489 | -0.4356 | 0.0000 | |
| GSE53624 | DEF8 | 54849 | 68092 | -0.0242 | 0.7809 | |
| GSE63941 | DEF8 | 54849 | 219646_at | -0.7596 | 0.3393 | |
| GSE77861 | DEF8 | 54849 | 225637_at | -0.2953 | 0.1015 | |
| GSE97050 | DEF8 | 54849 | A_24_P193582 | -0.3300 | 0.3389 | |
| SRP007169 | DEF8 | 54849 | RNAseq | -1.6122 | 0.0002 | |
| SRP008496 | DEF8 | 54849 | RNAseq | -1.2693 | 0.0000 | |
| SRP064894 | DEF8 | 54849 | RNAseq | -0.3151 | 0.1677 | |
| SRP133303 | DEF8 | 54849 | RNAseq | 0.3625 | 0.1482 | |
| SRP159526 | DEF8 | 54849 | RNAseq | -0.0389 | 0.9018 | |
| SRP193095 | DEF8 | 54849 | RNAseq | -0.1419 | 0.2840 | |
| SRP219564 | DEF8 | 54849 | RNAseq | -0.4421 | 0.0927 | |
| TCGA | DEF8 | 54849 | RNAseq | -0.1744 | 0.0008 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by DEF8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DEF8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DEF8 | 54849 | 4 | 3 | 23 | |
| GSE20123 | DEF8 | 54849 | 4 | 3 | 23 | |
| GSE43470 | DEF8 | 54849 | 1 | 13 | 29 | |
| GSE46452 | DEF8 | 54849 | 38 | 1 | 20 | |
| GSE47630 | DEF8 | 54849 | 11 | 9 | 20 | |
| GSE54993 | DEF8 | 54849 | 3 | 4 | 63 | |
| GSE54994 | DEF8 | 54849 | 9 | 11 | 33 | |
| GSE60625 | DEF8 | 54849 | 4 | 0 | 7 | |
| GSE74703 | DEF8 | 54849 | 1 | 9 | 26 | |
| GSE74704 | DEF8 | 54849 | 3 | 1 | 16 | |
| TCGA | DEF8 | 54849 | 26 | 15 | 55 |
Total number of gains: 104; Total number of losses: 69; Total Number of normals: 315.
Somatic mutations of DEF8:
Generating mutation plots.
Highly correlated genes for DEF8:
Showing top 20/737 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DEF8 | GOT1 | 0.740472 | 3 | 0 | 3 |
| DEF8 | DVL1 | 0.740385 | 3 | 0 | 3 |
| DEF8 | CYLD | 0.740223 | 3 | 0 | 3 |
| DEF8 | ST3GAL6 | 0.736848 | 4 | 0 | 4 |
| DEF8 | ABCG2 | 0.733445 | 3 | 0 | 3 |
| DEF8 | LNPEP | 0.72747 | 3 | 0 | 3 |
| DEF8 | SERTAD2 | 0.725195 | 3 | 0 | 3 |
| DEF8 | ZNF91 | 0.714209 | 4 | 0 | 4 |
| DEF8 | ARSG | 0.711302 | 4 | 0 | 3 |
| DEF8 | ZNF662 | 0.710502 | 6 | 0 | 6 |
| DEF8 | SFTA2 | 0.709948 | 4 | 0 | 4 |
| DEF8 | DIAPH1 | 0.709452 | 4 | 0 | 4 |
| DEF8 | SCAF4 | 0.705097 | 3 | 0 | 3 |
| DEF8 | TPCN1 | 0.704538 | 8 | 0 | 8 |
| DEF8 | PKN2 | 0.701417 | 4 | 0 | 3 |
| DEF8 | GRHPR | 0.698346 | 3 | 0 | 3 |
| DEF8 | AP3M1 | 0.696269 | 3 | 0 | 3 |
| DEF8 | SLC46A2 | 0.687967 | 6 | 0 | 6 |
| DEF8 | VPS53 | 0.687362 | 3 | 0 | 3 |
| DEF8 | FAM98C | 0.686102 | 4 | 0 | 4 |
For details and further investigation, click here
