| Full name: FERM domain containing 6 | Alias Symbol: MGC17921|willin|EX1 | ||
| Type: protein-coding gene | Cytoband: 14q22.1 | ||
| Entrez ID: 122786 | HGNC ID: HGNC:19839 | Ensembl Gene: ENSG00000139926 | OMIM ID: 614555 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
FRMD6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04390 | Hippo signaling pathway |
Expression of FRMD6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FRMD6 | 122786 | 225481_at | -0.2312 | 0.8100 | |
| GSE26886 | FRMD6 | 122786 | 225481_at | -0.6514 | 0.0037 | |
| GSE45670 | FRMD6 | 122786 | 225481_at | -0.2259 | 0.1218 | |
| GSE53622 | FRMD6 | 122786 | 69469 | 0.0886 | 0.5535 | |
| GSE53624 | FRMD6 | 122786 | 69469 | -0.2659 | 0.0331 | |
| GSE63941 | FRMD6 | 122786 | 225464_at | -1.4614 | 0.2328 | |
| GSE77861 | FRMD6 | 122786 | 225464_at | -0.0592 | 0.9241 | |
| GSE97050 | FRMD6 | 122786 | A_24_P330303 | 0.2634 | 0.3949 | |
| SRP007169 | FRMD6 | 122786 | RNAseq | -0.9842 | 0.0075 | |
| SRP008496 | FRMD6 | 122786 | RNAseq | -0.7480 | 0.0002 | |
| SRP064894 | FRMD6 | 122786 | RNAseq | -0.3843 | 0.1715 | |
| SRP133303 | FRMD6 | 122786 | RNAseq | -0.2438 | 0.3969 | |
| SRP159526 | FRMD6 | 122786 | RNAseq | -0.8059 | 0.0016 | |
| SRP193095 | FRMD6 | 122786 | RNAseq | -0.3022 | 0.3463 | |
| SRP219564 | FRMD6 | 122786 | RNAseq | -0.4760 | 0.4634 | |
| TCGA | FRMD6 | 122786 | RNAseq | 0.4247 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FRMD6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FRMD6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FRMD6 | 122786 | 9 | 3 | 18 | |
| GSE20123 | FRMD6 | 122786 | 9 | 3 | 18 | |
| GSE43470 | FRMD6 | 122786 | 9 | 1 | 33 | |
| GSE46452 | FRMD6 | 122786 | 16 | 3 | 40 | |
| GSE47630 | FRMD6 | 122786 | 11 | 10 | 19 | |
| GSE54993 | FRMD6 | 122786 | 3 | 8 | 59 | |
| GSE54994 | FRMD6 | 122786 | 19 | 4 | 30 | |
| GSE60625 | FRMD6 | 122786 | 0 | 2 | 9 | |
| GSE74703 | FRMD6 | 122786 | 8 | 1 | 27 | |
| GSE74704 | FRMD6 | 122786 | 4 | 2 | 14 | |
| TCGA | FRMD6 | 122786 | 35 | 13 | 48 |
Total number of gains: 123; Total number of losses: 50; Total Number of normals: 315.
Somatic mutations of FRMD6:
Generating mutation plots.
Highly correlated genes for FRMD6:
Showing top 20/540 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FRMD6 | ERI2 | 0.82005 | 3 | 0 | 3 |
| FRMD6 | BARD1 | 0.813829 | 3 | 0 | 3 |
| FRMD6 | MKKS | 0.80411 | 3 | 0 | 3 |
| FRMD6 | XPNPEP1 | 0.800093 | 3 | 0 | 3 |
| FRMD6 | RALGPS2 | 0.778396 | 3 | 0 | 3 |
| FRMD6 | EIF4G2 | 0.772984 | 3 | 0 | 3 |
| FRMD6 | ZFC3H1 | 0.771087 | 3 | 0 | 3 |
| FRMD6 | PPP4R2 | 0.770505 | 3 | 0 | 3 |
| FRMD6 | MIS18BP1 | 0.760228 | 3 | 0 | 3 |
| FRMD6 | TMEM186 | 0.759779 | 3 | 0 | 3 |
| FRMD6 | RNFT1 | 0.757143 | 3 | 0 | 3 |
| FRMD6 | KLHDC10 | 0.754399 | 3 | 0 | 3 |
| FRMD6 | SDHB | 0.750835 | 3 | 0 | 3 |
| FRMD6 | TIAL1 | 0.74979 | 3 | 0 | 3 |
| FRMD6 | OSBPL8 | 0.749653 | 4 | 0 | 4 |
| FRMD6 | THAP2 | 0.745228 | 3 | 0 | 3 |
| FRMD6 | NPAS2 | 0.743949 | 3 | 0 | 3 |
| FRMD6 | XRCC5 | 0.743463 | 4 | 0 | 3 |
| FRMD6 | ATP6V1G1 | 0.742666 | 3 | 0 | 3 |
| FRMD6 | ZNF398 | 0.740173 | 3 | 0 | 3 |
For details and further investigation, click here
