| Full name: two pore segment channel 1 | Alias Symbol: KIAA1169|FLJ20612|TPC1 | ||
| Type: protein-coding gene | Cytoband: 12q24.13 | ||
| Entrez ID: 53373 | HGNC ID: HGNC:18182 | Ensembl Gene: ENSG00000186815 | OMIM ID: 609666 |
| Drug and gene relationship at DGIdb | |||
Expression of TPCN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TPCN1 | 53373 | 217914_at | -0.5682 | 0.0939 | |
| GSE20347 | TPCN1 | 53373 | 217914_at | -1.1742 | 0.0000 | |
| GSE23400 | TPCN1 | 53373 | 217914_at | -0.8930 | 0.0000 | |
| GSE26886 | TPCN1 | 53373 | 217914_at | -1.1965 | 0.0000 | |
| GSE29001 | TPCN1 | 53373 | 217914_at | -1.0908 | 0.0001 | |
| GSE38129 | TPCN1 | 53373 | 217914_at | -1.0657 | 0.0000 | |
| GSE45670 | TPCN1 | 53373 | 217914_at | -0.6091 | 0.0119 | |
| GSE53622 | TPCN1 | 53373 | 108225 | -1.3335 | 0.0000 | |
| GSE53624 | TPCN1 | 53373 | 108225 | -1.1679 | 0.0000 | |
| GSE63941 | TPCN1 | 53373 | 217914_at | -0.1436 | 0.8104 | |
| GSE77861 | TPCN1 | 53373 | 217914_at | -0.7862 | 0.0136 | |
| GSE97050 | TPCN1 | 53373 | A_23_P218086 | -0.4982 | 0.1189 | |
| SRP007169 | TPCN1 | 53373 | RNAseq | -2.1046 | 0.0000 | |
| SRP008496 | TPCN1 | 53373 | RNAseq | -2.2532 | 0.0000 | |
| SRP064894 | TPCN1 | 53373 | RNAseq | -1.1166 | 0.0000 | |
| SRP133303 | TPCN1 | 53373 | RNAseq | -1.2586 | 0.0000 | |
| SRP159526 | TPCN1 | 53373 | RNAseq | -1.5330 | 0.0000 | |
| SRP193095 | TPCN1 | 53373 | RNAseq | -0.9455 | 0.0000 | |
| SRP219564 | TPCN1 | 53373 | RNAseq | -1.0890 | 0.0060 | |
| TCGA | TPCN1 | 53373 | RNAseq | -0.2737 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by TPCN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TPCN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TPCN1 | 53373 | 4 | 3 | 23 | |
| GSE20123 | TPCN1 | 53373 | 4 | 3 | 23 | |
| GSE43470 | TPCN1 | 53373 | 2 | 0 | 41 | |
| GSE46452 | TPCN1 | 53373 | 9 | 1 | 49 | |
| GSE47630 | TPCN1 | 53373 | 9 | 3 | 28 | |
| GSE54993 | TPCN1 | 53373 | 0 | 5 | 65 | |
| GSE54994 | TPCN1 | 53373 | 4 | 2 | 47 | |
| GSE60625 | TPCN1 | 53373 | 0 | 0 | 11 | |
| GSE74703 | TPCN1 | 53373 | 2 | 0 | 34 | |
| GSE74704 | TPCN1 | 53373 | 2 | 2 | 16 | |
| TCGA | TPCN1 | 53373 | 22 | 11 | 63 |
Total number of gains: 58; Total number of losses: 30; Total Number of normals: 400.
Somatic mutations of TPCN1:
Generating mutation plots.
Highly correlated genes for TPCN1:
Showing top 20/1898 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TPCN1 | RMND5B | 0.833777 | 11 | 0 | 11 |
| TPCN1 | SCNN1B | 0.820962 | 10 | 0 | 10 |
| TPCN1 | ARHGEF10L | 0.810711 | 12 | 0 | 12 |
| TPCN1 | MGLL | 0.808761 | 11 | 0 | 11 |
| TPCN1 | ECM1 | 0.805574 | 10 | 0 | 10 |
| TPCN1 | PADI1 | 0.80258 | 8 | 0 | 8 |
| TPCN1 | PLEKHM1 | 0.800533 | 11 | 0 | 11 |
| TPCN1 | CLIC3 | 0.796627 | 8 | 0 | 8 |
| TPCN1 | VAT1 | 0.796476 | 11 | 0 | 11 |
| TPCN1 | FNDC4 | 0.788311 | 10 | 0 | 10 |
| TPCN1 | EHD3 | 0.787185 | 11 | 0 | 11 |
| TPCN1 | VPS37B | 0.786658 | 11 | 0 | 10 |
| TPCN1 | FAM95B1 | 0.786476 | 4 | 0 | 4 |
| TPCN1 | USP54 | 0.785692 | 7 | 0 | 7 |
| TPCN1 | SORT1 | 0.785088 | 11 | 0 | 11 |
| TPCN1 | LRRFIP2 | 0.785 | 11 | 0 | 11 |
| TPCN1 | UPK1A | 0.784472 | 10 | 0 | 10 |
| TPCN1 | TRIP10 | 0.783859 | 12 | 0 | 11 |
| TPCN1 | ATP6V1C2 | 0.782365 | 4 | 0 | 4 |
| TPCN1 | GPD1L | 0.781528 | 11 | 0 | 11 |
For details and further investigation, click here
