| Full name: ETS proto-oncogene 1, transcription factor | Alias Symbol: FLJ10768|ETS-1 | ||
| Type: protein-coding gene | Cytoband: 11q24.3 | ||
| Entrez ID: 2113 | HGNC ID: HGNC:3488 | Ensembl Gene: ENSG00000134954 | OMIM ID: 164720 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ETS1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway | |
| hsa05200 | Pathways in cancer | |
| hsa05211 | Renal cell carcinoma |
Expression of ETS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ETS1 | 2113 | 224833_at | 0.3678 | 0.5655 | |
| GSE20347 | ETS1 | 2113 | 214447_at | -0.0926 | 0.2013 | |
| GSE23400 | ETS1 | 2113 | 214447_at | 0.0171 | 0.6504 | |
| GSE26886 | ETS1 | 2113 | 224833_at | 0.4893 | 0.2794 | |
| GSE29001 | ETS1 | 2113 | 214447_at | -0.2012 | 0.0914 | |
| GSE38129 | ETS1 | 2113 | 214447_at | -0.1671 | 0.0723 | |
| GSE45670 | ETS1 | 2113 | 224833_at | -0.3407 | 0.3972 | |
| GSE63941 | ETS1 | 2113 | 224833_at | -1.9495 | 0.0641 | |
| GSE77861 | ETS1 | 2113 | 214447_at | -0.1638 | 0.0736 | |
| GSE97050 | ETS1 | 2113 | A_24_P751074 | 0.8185 | 0.0631 | |
| SRP007169 | ETS1 | 2113 | RNAseq | 1.3611 | 0.0030 | |
| SRP008496 | ETS1 | 2113 | RNAseq | 1.7205 | 0.0000 | |
| SRP064894 | ETS1 | 2113 | RNAseq | 0.7995 | 0.0194 | |
| SRP133303 | ETS1 | 2113 | RNAseq | 0.4076 | 0.0677 | |
| SRP159526 | ETS1 | 2113 | RNAseq | -0.3628 | 0.5439 | |
| SRP193095 | ETS1 | 2113 | RNAseq | 0.9848 | 0.0001 | |
| SRP219564 | ETS1 | 2113 | RNAseq | 0.8901 | 0.0555 | |
| TCGA | ETS1 | 2113 | RNAseq | -0.1150 | 0.1751 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ETS1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ETS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ETS1 | 2113 | 0 | 14 | 16 | |
| GSE20123 | ETS1 | 2113 | 0 | 14 | 16 | |
| GSE43470 | ETS1 | 2113 | 2 | 7 | 34 | |
| GSE46452 | ETS1 | 2113 | 3 | 26 | 30 | |
| GSE47630 | ETS1 | 2113 | 2 | 19 | 19 | |
| GSE54993 | ETS1 | 2113 | 10 | 0 | 60 | |
| GSE54994 | ETS1 | 2113 | 5 | 19 | 29 | |
| GSE60625 | ETS1 | 2113 | 0 | 3 | 8 | |
| GSE74703 | ETS1 | 2113 | 1 | 5 | 30 | |
| GSE74704 | ETS1 | 2113 | 0 | 10 | 10 | |
| TCGA | ETS1 | 2113 | 6 | 50 | 40 |
Total number of gains: 29; Total number of losses: 167; Total Number of normals: 292.
Somatic mutations of ETS1:
Generating mutation plots.
Highly correlated genes for ETS1:
Showing top 20/411 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ETS1 | ZNF287 | 0.790166 | 3 | 0 | 3 |
| ETS1 | SNX12 | 0.750385 | 3 | 0 | 3 |
| ETS1 | MYT1 | 0.740534 | 3 | 0 | 3 |
| ETS1 | C3AR1 | 0.738871 | 4 | 0 | 4 |
| ETS1 | TNFAIP8L2 | 0.735135 | 3 | 0 | 3 |
| ETS1 | CD80 | 0.731791 | 3 | 0 | 3 |
| ETS1 | CD3E | 0.730603 | 4 | 0 | 4 |
| ETS1 | KCNJ2 | 0.728234 | 3 | 0 | 3 |
| ETS1 | MXD3 | 0.726796 | 3 | 0 | 3 |
| ETS1 | CYLD | 0.725563 | 3 | 0 | 3 |
| ETS1 | POU2F2 | 0.722175 | 4 | 0 | 4 |
| ETS1 | CD79B | 0.720476 | 3 | 0 | 3 |
| ETS1 | TCF25 | 0.71898 | 3 | 0 | 3 |
| ETS1 | FCRLA | 0.714219 | 3 | 0 | 3 |
| ETS1 | RHOG | 0.712826 | 3 | 0 | 3 |
| ETS1 | ATAT1 | 0.709136 | 3 | 0 | 3 |
| ETS1 | CDC42SE2 | 0.708955 | 4 | 0 | 3 |
| ETS1 | GBE1 | 0.702808 | 3 | 0 | 3 |
| ETS1 | C16orf54 | 0.701801 | 4 | 0 | 4 |
| ETS1 | CHN1 | 0.698286 | 6 | 0 | 6 |
For details and further investigation, click here
