| Full name: mitogen-activated protein kinase kinase kinase kinase 5 | Alias Symbol: KHS1|GCKR|KHS | ||
| Type: protein-coding gene | Cytoband: 14q22.1 | ||
| Entrez ID: 11183 | HGNC ID: HGNC:6867 | Ensembl Gene: ENSG00000012983 | OMIM ID: 604923 |
| Drug and gene relationship at DGIdb | |||
Expression of MAP4K5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAP4K5 | 11183 | 203552_at | -0.0323 | 0.9735 | |
| GSE20347 | MAP4K5 | 11183 | 203552_at | -0.1729 | 0.2397 | |
| GSE23400 | MAP4K5 | 11183 | 203552_at | 0.0908 | 0.3041 | |
| GSE26886 | MAP4K5 | 11183 | 203552_at | -0.8058 | 0.0064 | |
| GSE29001 | MAP4K5 | 11183 | 203552_at | 0.1192 | 0.6936 | |
| GSE38129 | MAP4K5 | 11183 | 203552_at | 0.0082 | 0.9625 | |
| GSE45670 | MAP4K5 | 11183 | 203552_at | -0.1248 | 0.2634 | |
| GSE53622 | MAP4K5 | 11183 | 54950 | 0.1161 | 0.1567 | |
| GSE53624 | MAP4K5 | 11183 | 54950 | 0.0009 | 0.9927 | |
| GSE63941 | MAP4K5 | 11183 | 203553_s_at | -0.1240 | 0.8078 | |
| GSE77861 | MAP4K5 | 11183 | 203552_at | -0.1224 | 0.7432 | |
| GSE97050 | MAP4K5 | 11183 | A_23_P205646 | 0.4298 | 0.1675 | |
| SRP007169 | MAP4K5 | 11183 | RNAseq | 0.2487 | 0.4182 | |
| SRP008496 | MAP4K5 | 11183 | RNAseq | 0.4429 | 0.0676 | |
| SRP064894 | MAP4K5 | 11183 | RNAseq | -0.1179 | 0.6595 | |
| SRP133303 | MAP4K5 | 11183 | RNAseq | 0.1219 | 0.4553 | |
| SRP159526 | MAP4K5 | 11183 | RNAseq | -0.3198 | 0.1801 | |
| SRP193095 | MAP4K5 | 11183 | RNAseq | -0.1844 | 0.1124 | |
| SRP219564 | MAP4K5 | 11183 | RNAseq | -0.0906 | 0.8257 | |
| TCGA | MAP4K5 | 11183 | RNAseq | 0.1104 | 0.0323 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MAP4K5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAP4K5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAP4K5 | 11183 | 8 | 2 | 20 | |
| GSE20123 | MAP4K5 | 11183 | 8 | 3 | 19 | |
| GSE43470 | MAP4K5 | 11183 | 9 | 1 | 33 | |
| GSE46452 | MAP4K5 | 11183 | 16 | 3 | 40 | |
| GSE47630 | MAP4K5 | 11183 | 11 | 10 | 19 | |
| GSE54993 | MAP4K5 | 11183 | 3 | 9 | 58 | |
| GSE54994 | MAP4K5 | 11183 | 20 | 4 | 29 | |
| GSE60625 | MAP4K5 | 11183 | 0 | 2 | 9 | |
| GSE74703 | MAP4K5 | 11183 | 8 | 1 | 27 | |
| GSE74704 | MAP4K5 | 11183 | 3 | 2 | 15 | |
| TCGA | MAP4K5 | 11183 | 34 | 13 | 49 |
Total number of gains: 120; Total number of losses: 50; Total Number of normals: 318.
Somatic mutations of MAP4K5:
Generating mutation plots.
Highly correlated genes for MAP4K5:
Showing top 20/543 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAP4K5 | PPP4R2 | 0.87884 | 3 | 0 | 3 |
| MAP4K5 | TMEM69 | 0.875185 | 3 | 0 | 3 |
| MAP4K5 | SPIN4 | 0.843964 | 3 | 0 | 3 |
| MAP4K5 | RRAGC | 0.807097 | 3 | 0 | 3 |
| MAP4K5 | IPMK | 0.804253 | 3 | 0 | 3 |
| MAP4K5 | MYSM1 | 0.788446 | 4 | 0 | 4 |
| MAP4K5 | LNX2 | 0.787547 | 3 | 0 | 3 |
| MAP4K5 | WIPI2 | 0.787333 | 3 | 0 | 3 |
| MAP4K5 | MTIF2 | 0.776622 | 3 | 0 | 3 |
| MAP4K5 | SLC10A7 | 0.775027 | 3 | 0 | 3 |
| MAP4K5 | TMEM186 | 0.766848 | 3 | 0 | 3 |
| MAP4K5 | OXNAD1 | 0.751151 | 3 | 0 | 3 |
| MAP4K5 | TBC1D23 | 0.742931 | 3 | 0 | 3 |
| MAP4K5 | ZNF627 | 0.742106 | 3 | 0 | 3 |
| MAP4K5 | THAP2 | 0.741976 | 3 | 0 | 3 |
| MAP4K5 | GRPEL1 | 0.740017 | 3 | 0 | 3 |
| MAP4K5 | MKKS | 0.739409 | 3 | 0 | 3 |
| MAP4K5 | RNF144B | 0.737893 | 4 | 0 | 3 |
| MAP4K5 | CHM | 0.735991 | 3 | 0 | 3 |
| MAP4K5 | MIS18BP1 | 0.735793 | 3 | 0 | 3 |
For details and further investigation, click here
