| Full name: mitochondrial ribosomal protein S22 | Alias Symbol: MRP-S22|GK002|C3orf5|GIBT | ||
| Type: protein-coding gene | Cytoband: 3q23 | ||
| Entrez ID: 56945 | HGNC ID: HGNC:14508 | Ensembl Gene: ENSG00000175110 | OMIM ID: 605810 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MRPS22:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPS22 | 56945 | 219220_x_at | 0.1278 | 0.7453 | |
| GSE20347 | MRPS22 | 56945 | 219220_x_at | 0.0346 | 0.7461 | |
| GSE23400 | MRPS22 | 56945 | 219220_x_at | 0.2714 | 0.0012 | |
| GSE26886 | MRPS22 | 56945 | 226257_x_at | -0.1840 | 0.3844 | |
| GSE29001 | MRPS22 | 56945 | 219220_x_at | 0.1403 | 0.6320 | |
| GSE38129 | MRPS22 | 56945 | 219220_x_at | 0.0577 | 0.6698 | |
| GSE45670 | MRPS22 | 56945 | 219220_x_at | 0.1457 | 0.2850 | |
| GSE53622 | MRPS22 | 56945 | 14283 | 0.1130 | 0.0509 | |
| GSE53624 | MRPS22 | 56945 | 14283 | 0.3408 | 0.0000 | |
| GSE63941 | MRPS22 | 56945 | 219220_x_at | 0.9716 | 0.0081 | |
| GSE77861 | MRPS22 | 56945 | 228059_x_at | -0.0658 | 0.7880 | |
| GSE97050 | MRPS22 | 56945 | A_23_P72138 | -0.0045 | 0.9849 | |
| SRP007169 | MRPS22 | 56945 | RNAseq | 0.0408 | 0.9113 | |
| SRP008496 | MRPS22 | 56945 | RNAseq | -0.1733 | 0.4444 | |
| SRP064894 | MRPS22 | 56945 | RNAseq | 0.1666 | 0.4234 | |
| SRP133303 | MRPS22 | 56945 | RNAseq | 0.2132 | 0.1156 | |
| SRP159526 | MRPS22 | 56945 | RNAseq | 0.1330 | 0.7273 | |
| SRP193095 | MRPS22 | 56945 | RNAseq | -0.1429 | 0.3430 | |
| SRP219564 | MRPS22 | 56945 | RNAseq | -0.1768 | 0.5621 | |
| TCGA | MRPS22 | 56945 | RNAseq | 0.1817 | 0.0024 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MRPS22 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPS22:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPS22 | 56945 | 18 | 0 | 12 | |
| GSE20123 | MRPS22 | 56945 | 18 | 0 | 12 | |
| GSE43470 | MRPS22 | 56945 | 22 | 0 | 21 | |
| GSE46452 | MRPS22 | 56945 | 15 | 4 | 40 | |
| GSE47630 | MRPS22 | 56945 | 18 | 3 | 19 | |
| GSE54993 | MRPS22 | 56945 | 2 | 8 | 60 | |
| GSE54994 | MRPS22 | 56945 | 32 | 1 | 20 | |
| GSE60625 | MRPS22 | 56945 | 0 | 6 | 5 | |
| GSE74703 | MRPS22 | 56945 | 19 | 0 | 17 | |
| GSE74704 | MRPS22 | 56945 | 12 | 0 | 8 | |
| TCGA | MRPS22 | 56945 | 62 | 4 | 30 |
Total number of gains: 218; Total number of losses: 26; Total Number of normals: 244.
Somatic mutations of MRPS22:
Generating mutation plots.
Highly correlated genes for MRPS22:
Showing top 20/443 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPS22 | PIBF1 | 0.791086 | 3 | 0 | 3 |
| MRPS22 | CDC73 | 0.778093 | 3 | 0 | 3 |
| MRPS22 | STYX | 0.769525 | 3 | 0 | 3 |
| MRPS22 | NUCKS1 | 0.760344 | 3 | 0 | 3 |
| MRPS22 | SYNE2 | 0.752149 | 3 | 0 | 3 |
| MRPS22 | INTS6 | 0.747303 | 3 | 0 | 3 |
| MRPS22 | GNL3L | 0.743367 | 4 | 0 | 4 |
| MRPS22 | FASTKD3 | 0.736961 | 3 | 0 | 3 |
| MRPS22 | VGLL4 | 0.735432 | 3 | 0 | 3 |
| MRPS22 | CYLD | 0.73028 | 3 | 0 | 3 |
| MRPS22 | NOP14-AS1 | 0.718886 | 3 | 0 | 3 |
| MRPS22 | PLEKHB2 | 0.713408 | 3 | 0 | 3 |
| MRPS22 | CWC15 | 0.709565 | 3 | 0 | 3 |
| MRPS22 | SNW1 | 0.709175 | 4 | 0 | 3 |
| MRPS22 | EBAG9 | 0.709134 | 4 | 0 | 3 |
| MRPS22 | SP3 | 0.708379 | 3 | 0 | 3 |
| MRPS22 | SLC25A3 | 0.707038 | 3 | 0 | 3 |
| MRPS22 | RNF138 | 0.706694 | 3 | 0 | 3 |
| MRPS22 | ZNF202 | 0.705637 | 3 | 0 | 3 |
| MRPS22 | ZNF90 | 0.702413 | 3 | 0 | 3 |
For details and further investigation, click here
