| Full name: cytochrome P450 family 24 subfamily A member 1 | Alias Symbol: CP24|P450-CC24 | ||
| Type: protein-coding gene | Cytoband: 20q13.2 | ||
| Entrez ID: 1591 | HGNC ID: HGNC:2602 | Ensembl Gene: ENSG00000019186 | OMIM ID: 126065 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP24A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP24A1 | 1591 | 206504_at | 1.6434 | 0.4701 | |
| GSE20347 | CYP24A1 | 1591 | 206504_at | 0.7522 | 0.0545 | |
| GSE23400 | CYP24A1 | 1591 | 206504_at | 0.8600 | 0.0000 | |
| GSE26886 | CYP24A1 | 1591 | 206504_at | 1.7277 | 0.0376 | |
| GSE29001 | CYP24A1 | 1591 | 206504_at | 1.9281 | 0.0382 | |
| GSE38129 | CYP24A1 | 1591 | 206504_at | 1.1004 | 0.0013 | |
| GSE45670 | CYP24A1 | 1591 | 206504_at | 2.0223 | 0.0091 | |
| GSE53622 | CYP24A1 | 1591 | 55779 | 1.0223 | 0.0000 | |
| GSE53624 | CYP24A1 | 1591 | 55779 | 0.7769 | 0.0000 | |
| GSE63941 | CYP24A1 | 1591 | 206504_at | -0.8632 | 0.6646 | |
| GSE77861 | CYP24A1 | 1591 | 206504_at | 0.5455 | 0.3453 | |
| GSE97050 | CYP24A1 | 1591 | A_23_P28815 | 1.0282 | 0.2151 | |
| SRP008496 | CYP24A1 | 1591 | RNAseq | 1.0193 | 0.1068 | |
| SRP133303 | CYP24A1 | 1591 | RNAseq | 1.8878 | 0.0040 | |
| SRP159526 | CYP24A1 | 1591 | RNAseq | -0.5014 | 0.5888 | |
| SRP219564 | CYP24A1 | 1591 | RNAseq | 1.2130 | 0.4006 | |
| TCGA | CYP24A1 | 1591 | RNAseq | 1.6538 | 0.0000 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by CYP24A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP24A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP24A1 | 1591 | 15 | 1 | 14 | |
| GSE20123 | CYP24A1 | 1591 | 16 | 1 | 13 | |
| GSE43470 | CYP24A1 | 1591 | 14 | 0 | 29 | |
| GSE46452 | CYP24A1 | 1591 | 29 | 0 | 30 | |
| GSE47630 | CYP24A1 | 1591 | 24 | 1 | 15 | |
| GSE54993 | CYP24A1 | 1591 | 0 | 17 | 53 | |
| GSE54994 | CYP24A1 | 1591 | 27 | 0 | 26 | |
| GSE60625 | CYP24A1 | 1591 | 0 | 0 | 11 | |
| GSE74703 | CYP24A1 | 1591 | 11 | 0 | 25 | |
| GSE74704 | CYP24A1 | 1591 | 12 | 0 | 8 | |
| TCGA | CYP24A1 | 1591 | 45 | 3 | 48 |
Total number of gains: 193; Total number of losses: 23; Total Number of normals: 272.
Somatic mutations of CYP24A1:
Generating mutation plots.
Highly correlated genes for CYP24A1:
Showing top 20/104 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP24A1 | UBTD2 | 0.66961 | 3 | 0 | 3 |
| CYP24A1 | EYA4 | 0.623393 | 4 | 0 | 4 |
| CYP24A1 | CEACAM19 | 0.618394 | 3 | 0 | 3 |
| CYP24A1 | TFPI2 | 0.615718 | 4 | 0 | 4 |
| CYP24A1 | CHAF1A | 0.613303 | 3 | 0 | 3 |
| CYP24A1 | ARHGAP4 | 0.610514 | 3 | 0 | 3 |
| CYP24A1 | BIRC2 | 0.603917 | 5 | 0 | 4 |
| CYP24A1 | XDH | 0.603234 | 3 | 0 | 3 |
| CYP24A1 | KREMEN2 | 0.601688 | 7 | 0 | 5 |
| CYP24A1 | TNIP3 | 0.594286 | 8 | 0 | 4 |
| CYP24A1 | CCL20 | 0.594225 | 10 | 0 | 7 |
| CYP24A1 | TNFRSF11B | 0.591827 | 5 | 0 | 3 |
| CYP24A1 | PF4V1 | 0.589089 | 5 | 0 | 3 |
| CYP24A1 | CD151 | 0.582516 | 3 | 0 | 3 |
| CYP24A1 | FARSA | 0.580984 | 5 | 0 | 3 |
| CYP24A1 | GINS4 | 0.579881 | 7 | 0 | 3 |
| CYP24A1 | GRWD1 | 0.579182 | 4 | 0 | 3 |
| CYP24A1 | MAD2L1 | 0.576258 | 8 | 0 | 5 |
| CYP24A1 | OSGEPL1 | 0.5715 | 4 | 0 | 3 |
| CYP24A1 | SERPINA9 | 0.570411 | 3 | 0 | 3 |
For details and further investigation, click here
