| Full name: platelet factor 4 variant 1 | Alias Symbol: SCYB4V1|CXCL4V1|CXCL4L1 | ||
| Type: protein-coding gene | Cytoband: 4q13.3 | ||
| Entrez ID: 5197 | HGNC ID: HGNC:8862 | Ensembl Gene: ENSG00000109272 | OMIM ID: 173461 |
| Drug and gene relationship at DGIdb | |||
PF4V1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of PF4V1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PF4V1 | 5197 | 207815_at | 0.2495 | 0.4310 | |
| GSE20347 | PF4V1 | 5197 | 207815_at | 0.0210 | 0.8365 | |
| GSE23400 | PF4V1 | 5197 | 207815_at | -0.0041 | 0.8070 | |
| GSE26886 | PF4V1 | 5197 | 207815_at | 0.1890 | 0.1256 | |
| GSE29001 | PF4V1 | 5197 | 207815_at | 0.1448 | 0.2709 | |
| GSE38129 | PF4V1 | 5197 | 207815_at | 0.0248 | 0.8173 | |
| GSE45670 | PF4V1 | 5197 | 207815_at | 0.4871 | 0.1442 | |
| GSE63941 | PF4V1 | 5197 | 207815_at | -3.4375 | 0.0004 | |
| GSE77861 | PF4V1 | 5197 | 207815_at | 0.0750 | 0.4077 | |
| TCGA | PF4V1 | 5197 | RNAseq | 3.2830 | 0.0004 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by PF4V1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PF4V1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PF4V1 | 5197 | 2 | 9 | 19 | |
| GSE20123 | PF4V1 | 5197 | 2 | 9 | 19 | |
| GSE43470 | PF4V1 | 5197 | 0 | 13 | 30 | |
| GSE46452 | PF4V1 | 5197 | 3 | 34 | 22 | |
| GSE47630 | PF4V1 | 5197 | 1 | 19 | 20 | |
| GSE54993 | PF4V1 | 5197 | 7 | 0 | 63 | |
| GSE54994 | PF4V1 | 5197 | 1 | 9 | 43 | |
| GSE60625 | PF4V1 | 5197 | 0 | 0 | 11 | |
| GSE74703 | PF4V1 | 5197 | 0 | 11 | 25 | |
| GSE74704 | PF4V1 | 5197 | 2 | 5 | 13 | |
| TCGA | PF4V1 | 5197 | 19 | 27 | 50 |
Total number of gains: 37; Total number of losses: 136; Total Number of normals: 315.
Somatic mutations of PF4V1:
Generating mutation plots.
Highly correlated genes for PF4V1:
Showing top 20/73 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PF4V1 | CMTM2 | 0.708505 | 3 | 0 | 3 |
| PF4V1 | FCGR3B | 0.675151 | 5 | 0 | 4 |
| PF4V1 | RGS18 | 0.674003 | 3 | 0 | 3 |
| PF4V1 | RCN1 | 0.652218 | 3 | 0 | 3 |
| PF4V1 | IL13RA2 | 0.651457 | 4 | 0 | 4 |
| PF4V1 | CHI3L1 | 0.638846 | 3 | 0 | 3 |
| PF4V1 | PRRX1 | 0.63559 | 4 | 0 | 3 |
| PF4V1 | KCND2 | 0.635321 | 3 | 0 | 3 |
| PF4V1 | CXCL6 | 0.629652 | 8 | 0 | 7 |
| PF4V1 | HGF | 0.620063 | 3 | 0 | 3 |
| PF4V1 | LAYN | 0.618507 | 3 | 0 | 3 |
| PF4V1 | BIRC3 | 0.612123 | 4 | 0 | 3 |
| PF4V1 | UNC5C | 0.611185 | 3 | 0 | 3 |
| PF4V1 | NFKBIE | 0.61054 | 4 | 0 | 3 |
| PF4V1 | LILRA3 | 0.609818 | 5 | 0 | 5 |
| PF4V1 | ITGA1 | 0.609305 | 3 | 0 | 3 |
| PF4V1 | TFPI2 | 0.604643 | 4 | 0 | 3 |
| PF4V1 | C9 | 0.602483 | 3 | 0 | 3 |
| PF4V1 | TNFAIP6 | 0.600832 | 4 | 0 | 3 |
| PF4V1 | THY1 | 0.599497 | 4 | 0 | 3 |
For details and further investigation, click here
