Full name: baculoviral IAP repeat containing 2	Alias Symbol: cIAP1|hiap-2|MIHB|RNF48|c-IAP1
Type: protein-coding gene	Cytoband: 11q22.2
Entrez ID: 329	HGNC ID: HGNC:590	Ensembl Gene: ENSG00000110330	OMIM ID: 601712
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 49/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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BIRC2 involved pathways:

KEGG pathway	Description	View
hsa04064	NF-kappa B signaling pathway	View
hsa04210	Apoptosis	View
hsa04390	Hippo signaling pathway	View
hsa04510	Focal adhesion	View
hsa04621	NOD-like receptor signaling pathway	View
hsa04668	TNF signaling pathway	View
hsa05145	Toxoplasmosis	View
hsa05200	Pathways in cancer	View
hsa05222	Small cell lung cancer	View

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Expression of BIRC2:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	BIRC2	329	202076_at	0.2220	0.6166	Show
GSE20347	BIRC2	329	202076_at	0.8131	0.0369	Show
GSE23400	BIRC2	329	202076_at	0.5858	0.0000	Show
GSE26886	BIRC2	329	202076_at	0.4638	0.0696	Show
GSE29001	BIRC2	329	202076_at	0.1896	0.3317	Show
GSE38129	BIRC2	329	202076_at	0.6276	0.0126	Show
GSE45670	BIRC2	329	202076_at	0.4067	0.1725	Show
GSE53622	BIRC2	329	27015	0.6853	0.0000	Show
GSE53624	BIRC2	329	27015	0.3604	0.0003	Show
GSE63941	BIRC2	329	202076_at	-0.7066	0.3661	Show
GSE77861	BIRC2	329	202076_at	0.3226	0.2621	Show
GSE97050	BIRC2	329	A_24_P115774	0.3532	0.3192	Show
SRP008496	BIRC2	329	RNAseq	0.2939	0.2665	Show
SRP064894	BIRC2	329	RNAseq	0.7979	0.0124	Show
SRP133303	BIRC2	329	RNAseq	0.3844	0.0351	Show
SRP159526	BIRC2	329	RNAseq	0.2032	0.4439	Show
SRP193095	BIRC2	329	RNAseq	-0.1943	0.0803	Show
SRP219564	BIRC2	329	RNAseq	1.1922	0.0122	Show
TCGA	BIRC2	329	RNAseq	0.0159	0.7418	Show

Upregulated datasets: 1; Downregulated datasets: 0.  Download Data

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Survival by BIRC2 expression:

 

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Copy number change of BIRC2:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	BIRC2	329	5	8	17	Show
GSE20123	BIRC2	329	5	8	17	Show
GSE43470	BIRC2	329	6	5	32	Show
GSE46452	BIRC2	329	5	24	30	Show
GSE47630	BIRC2	329	2	19	19	Show
GSE54993	BIRC2	329	9	2	59	Show
GSE54994	BIRC2	329	6	18	29	Show
GSE60625	BIRC2	329	0	3	8	Show
GSE74703	BIRC2	329	4	4	28	Show
GSE74704	BIRC2	329	5	4	11	Show
TCGA	BIRC2	329	11	44	41	Show

Total number of gains: 58; Total number of losses: 139; Total Number of normals: 291.  Download Data

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Somatic mutations of BIRC2:

 

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Highly correlated genes for BIRC2:

 

Showing top 20/681 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
BIRC2	STEAP1B	0.762657	4	0	4
BIRC2	TMX3	0.762015	3	0	3
BIRC2	RICTOR	0.756425	3	0	3
BIRC2	TMEM181	0.753314	3	0	3
BIRC2	NFKB1	0.751457	3	0	3
BIRC2	CTBP2	0.740348	3	0	3
BIRC2	TMEM123	0.739139	13	0	11
BIRC2	ZNF121	0.738365	3	0	3
BIRC2	INTS4	0.738064	3	0	3
BIRC2	MTRR	0.73444	4	0	3
BIRC2	YAP1	0.733025	8	0	7
BIRC2	NIPA2	0.730177	3	0	3
BIRC2	PGM2L1	0.718416	3	0	3
BIRC2	INTS10	0.713533	4	0	3
BIRC2	CRIM1	0.712889	3	0	3
BIRC2	ARHGAP42	0.706807	4	0	3
BIRC2	NBN	0.705088	3	0	3
BIRC2	RBPJ	0.703529	3	0	3
BIRC2	ZSCAN21	0.699901	3	0	3
BIRC2	SPATA5	0.698072	3	0	3

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