| Full name: C-C motif chemokine ligand 20 | Alias Symbol: LARC|MIP-3a|exodus-1|ST38|CKb4 | ||
| Type: protein-coding gene | Cytoband: 2q36.3 | ||
| Entrez ID: 6364 | HGNC ID: HGNC:10619 | Ensembl Gene: ENSG00000115009 | OMIM ID: 601960 |
| Drug and gene relationship at DGIdb | |||
CCL20 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of CCL20:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCL20 | 6364 | 205476_at | 1.8850 | 0.4532 | |
| GSE20347 | CCL20 | 6364 | 205476_at | 1.8949 | 0.0018 | |
| GSE23400 | CCL20 | 6364 | 205476_at | 1.0799 | 0.0005 | |
| GSE26886 | CCL20 | 6364 | 205476_at | 0.1129 | 0.9112 | |
| GSE29001 | CCL20 | 6364 | 205476_at | 1.7308 | 0.0067 | |
| GSE38129 | CCL20 | 6364 | 205476_at | 1.6665 | 0.0007 | |
| GSE45670 | CCL20 | 6364 | 205476_at | 2.0858 | 0.0051 | |
| GSE53622 | CCL20 | 6364 | 47779 | 1.7670 | 0.0000 | |
| GSE53624 | CCL20 | 6364 | 47779 | 1.0393 | 0.0000 | |
| GSE63941 | CCL20 | 6364 | 205476_at | 1.5498 | 0.2976 | |
| GSE77861 | CCL20 | 6364 | 205476_at | 1.5339 | 0.0954 | |
| GSE97050 | CCL20 | 6364 | A_23_P17065 | 1.3949 | 0.1531 | |
| SRP064894 | CCL20 | 6364 | RNAseq | 3.1275 | 0.0000 | |
| SRP133303 | CCL20 | 6364 | RNAseq | 2.8801 | 0.0000 | |
| SRP159526 | CCL20 | 6364 | RNAseq | 0.6103 | 0.5350 | |
| SRP193095 | CCL20 | 6364 | RNAseq | 1.6114 | 0.0003 | |
| SRP219564 | CCL20 | 6364 | RNAseq | 2.8510 | 0.0104 | |
| TCGA | CCL20 | 6364 | RNAseq | 1.7140 | 0.0000 |
Upregulated datasets: 12; Downregulated datasets: 0.
Survival by CCL20 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCL20:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCL20 | 6364 | 2 | 12 | 16 | |
| GSE20123 | CCL20 | 6364 | 2 | 12 | 16 | |
| GSE43470 | CCL20 | 6364 | 1 | 7 | 35 | |
| GSE46452 | CCL20 | 6364 | 0 | 5 | 54 | |
| GSE47630 | CCL20 | 6364 | 4 | 5 | 31 | |
| GSE54993 | CCL20 | 6364 | 1 | 2 | 67 | |
| GSE54994 | CCL20 | 6364 | 6 | 11 | 36 | |
| GSE60625 | CCL20 | 6364 | 0 | 3 | 8 | |
| GSE74703 | CCL20 | 6364 | 1 | 6 | 29 | |
| GSE74704 | CCL20 | 6364 | 2 | 6 | 12 | |
| TCGA | CCL20 | 6364 | 13 | 26 | 57 |
Total number of gains: 32; Total number of losses: 95; Total Number of normals: 361.
Somatic mutations of CCL20:
Generating mutation plots.
Highly correlated genes for CCL20:
Showing top 20/184 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCL20 | FANCM | 0.722139 | 3 | 0 | 3 |
| CCL20 | TMEM14A | 0.720283 | 3 | 0 | 3 |
| CCL20 | IL36G | 0.685579 | 11 | 0 | 10 |
| CCL20 | CXCL1 | 0.662136 | 13 | 0 | 12 |
| CCL20 | CXCL8 | 0.656271 | 11 | 0 | 10 |
| CCL20 | TXNDC12 | 0.627491 | 4 | 0 | 3 |
| CCL20 | CASP14 | 0.621265 | 4 | 0 | 4 |
| CCL20 | RAB3IP | 0.615374 | 4 | 0 | 4 |
| CCL20 | MATN3 | 0.612007 | 7 | 0 | 4 |
| CCL20 | IL1B | 0.610749 | 12 | 0 | 11 |
| CCL20 | CEACAM19 | 0.609285 | 5 | 0 | 3 |
| CCL20 | RCC2 | 0.608085 | 4 | 0 | 3 |
| CCL20 | LINC01137 | 0.607357 | 4 | 0 | 3 |
| CCL20 | AFAP1L2 | 0.602751 | 5 | 0 | 4 |
| CCL20 | EME1 | 0.601693 | 4 | 0 | 4 |
| CCL20 | SPRR4 | 0.599952 | 4 | 0 | 3 |
| CCL20 | MKI67 | 0.599584 | 6 | 0 | 5 |
| CCL20 | CTSB | 0.599201 | 3 | 0 | 3 |
| CCL20 | PSMA7 | 0.598521 | 4 | 0 | 3 |
| CCL20 | BRIP1 | 0.596005 | 5 | 0 | 3 |
For details and further investigation, click here
