| Full name: TNF receptor superfamily member 11b | Alias Symbol: OCIF|TR1 | ||
| Type: protein-coding gene | Cytoband: 8q24.12 | ||
| Entrez ID: 4982 | HGNC ID: HGNC:11909 | Ensembl Gene: ENSG00000164761 | OMIM ID: 602643 |
| Drug and gene relationship at DGIdb | |||
TNFRSF11B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04380 | Osteoclast differentiation |
Expression of TNFRSF11B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNFRSF11B | 4982 | 204933_s_at | 0.0337 | 0.9676 | |
| GSE20347 | TNFRSF11B | 4982 | 204933_s_at | 0.3765 | 0.3379 | |
| GSE23400 | TNFRSF11B | 4982 | 204933_s_at | -0.0657 | 0.0119 | |
| GSE26886 | TNFRSF11B | 4982 | 204933_s_at | 0.4925 | 0.0402 | |
| GSE29001 | TNFRSF11B | 4982 | 204932_at | 0.1622 | 0.4152 | |
| GSE38129 | TNFRSF11B | 4982 | 204933_s_at | 0.3477 | 0.1578 | |
| GSE45670 | TNFRSF11B | 4982 | 204933_s_at | 0.5263 | 0.1956 | |
| GSE53622 | TNFRSF11B | 4982 | 16090 | 1.1322 | 0.0000 | |
| GSE53624 | TNFRSF11B | 4982 | 114940 | -0.2009 | 0.0576 | |
| GSE63941 | TNFRSF11B | 4982 | 204933_s_at | -8.2496 | 0.0000 | |
| GSE77861 | TNFRSF11B | 4982 | 204933_s_at | 0.1061 | 0.3452 | |
| GSE97050 | TNFRSF11B | 4982 | A_23_P71530 | 0.9664 | 0.1421 | |
| SRP133303 | TNFRSF11B | 4982 | RNAseq | 0.9807 | 0.0741 | |
| SRP159526 | TNFRSF11B | 4982 | RNAseq | 3.1524 | 0.0000 | |
| SRP219564 | TNFRSF11B | 4982 | RNAseq | 2.4474 | 0.0000 | |
| TCGA | TNFRSF11B | 4982 | RNAseq | 0.2367 | 0.4451 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by TNFRSF11B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNFRSF11B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNFRSF11B | 4982 | 19 | 1 | 10 | |
| GSE20123 | TNFRSF11B | 4982 | 20 | 1 | 9 | |
| GSE43470 | TNFRSF11B | 4982 | 23 | 0 | 20 | |
| GSE46452 | TNFRSF11B | 4982 | 26 | 0 | 33 | |
| GSE47630 | TNFRSF11B | 4982 | 24 | 0 | 16 | |
| GSE54993 | TNFRSF11B | 4982 | 0 | 20 | 50 | |
| GSE54994 | TNFRSF11B | 4982 | 37 | 1 | 15 | |
| GSE60625 | TNFRSF11B | 4982 | 0 | 4 | 7 | |
| GSE74703 | TNFRSF11B | 4982 | 19 | 0 | 17 | |
| GSE74704 | TNFRSF11B | 4982 | 13 | 1 | 6 | |
| TCGA | TNFRSF11B | 4982 | 66 | 2 | 28 |
Total number of gains: 247; Total number of losses: 30; Total Number of normals: 211.
Somatic mutations of TNFRSF11B:
Generating mutation plots.
Highly correlated genes for TNFRSF11B:
Showing top 20/117 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNFRSF11B | FGF3 | 0.76975 | 6 | 0 | 5 |
| TNFRSF11B | CSGALNACT1 | 0.674844 | 4 | 0 | 4 |
| TNFRSF11B | CXCL5 | 0.670965 | 5 | 0 | 4 |
| TNFRSF11B | ANPEP | 0.67009 | 4 | 0 | 3 |
| TNFRSF11B | FHOD3 | 0.669751 | 5 | 0 | 5 |
| TNFRSF11B | ATP8A2 | 0.669155 | 7 | 0 | 5 |
| TNFRSF11B | LMAN1 | 0.663087 | 3 | 0 | 3 |
| TNFRSF11B | GK | 0.65161 | 3 | 0 | 3 |
| TNFRSF11B | POU5F2 | 0.651587 | 3 | 0 | 3 |
| TNFRSF11B | TRPC6 | 0.647954 | 4 | 0 | 3 |
| TNFRSF11B | GFRA1 | 0.643024 | 6 | 0 | 3 |
| TNFRSF11B | C1QTNF1 | 0.64221 | 5 | 0 | 5 |
| TNFRSF11B | ENG | 0.640272 | 4 | 0 | 3 |
| TNFRSF11B | LAYN | 0.634477 | 5 | 0 | 4 |
| TNFRSF11B | FAP | 0.633241 | 4 | 0 | 3 |
| TNFRSF11B | HLX | 0.631032 | 4 | 0 | 3 |
| TNFRSF11B | ICAM2 | 0.627641 | 4 | 0 | 3 |
| TNFRSF11B | SULT1E1 | 0.621701 | 4 | 0 | 3 |
| TNFRSF11B | COL8A2 | 0.620244 | 4 | 0 | 3 |
| TNFRSF11B | GSTA3 | 0.61965 | 4 | 0 | 3 |
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