| Full name: GINS complex subunit 4 | Alias Symbol: MGC14799|SLD5 | ||
| Type: protein-coding gene | Cytoband: 8p11.21 | ||
| Entrez ID: 84296 | HGNC ID: HGNC:28226 | Ensembl Gene: ENSG00000147536 | OMIM ID: 610611 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of GINS4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GINS4 | 84296 | 211767_at | 1.1245 | 0.1900 | |
| GSE20347 | GINS4 | 84296 | 211767_at | 1.0091 | 0.0000 | |
| GSE23400 | GINS4 | 84296 | 211767_at | 0.4534 | 0.0000 | |
| GSE26886 | GINS4 | 84296 | 211767_at | -0.0283 | 0.9164 | |
| GSE29001 | GINS4 | 84296 | 211767_at | 0.7964 | 0.0494 | |
| GSE38129 | GINS4 | 84296 | 211767_at | 0.9678 | 0.0002 | |
| GSE45670 | GINS4 | 84296 | 211767_at | 1.0538 | 0.0000 | |
| GSE63941 | GINS4 | 84296 | 211767_at | 1.6737 | 0.0021 | |
| GSE77861 | GINS4 | 84296 | 211767_at | 0.0282 | 0.8989 | |
| GSE97050 | GINS4 | 84296 | A_33_P3340040 | 0.8011 | 0.1924 | |
| SRP007169 | GINS4 | 84296 | RNAseq | 1.5159 | 0.0002 | |
| SRP008496 | GINS4 | 84296 | RNAseq | 1.0010 | 0.0031 | |
| SRP064894 | GINS4 | 84296 | RNAseq | 1.3167 | 0.0000 | |
| SRP133303 | GINS4 | 84296 | RNAseq | 1.1097 | 0.0000 | |
| SRP159526 | GINS4 | 84296 | RNAseq | 2.2735 | 0.0015 | |
| SRP193095 | GINS4 | 84296 | RNAseq | 0.7866 | 0.0000 | |
| SRP219564 | GINS4 | 84296 | RNAseq | 1.5636 | 0.0007 | |
| TCGA | GINS4 | 84296 | RNAseq | 1.1876 | 0.0000 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by GINS4 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GINS4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GINS4 | 84296 | 10 | 5 | 15 | |
| GSE20123 | GINS4 | 84296 | 10 | 6 | 14 | |
| GSE43470 | GINS4 | 84296 | 9 | 6 | 28 | |
| GSE46452 | GINS4 | 84296 | 19 | 5 | 35 | |
| GSE47630 | GINS4 | 84296 | 22 | 1 | 17 | |
| GSE54993 | GINS4 | 84296 | 1 | 16 | 53 | |
| GSE54994 | GINS4 | 84296 | 18 | 8 | 27 | |
| GSE60625 | GINS4 | 84296 | 3 | 0 | 8 | |
| GSE74703 | GINS4 | 84296 | 8 | 5 | 23 | |
| GSE74704 | GINS4 | 84296 | 9 | 2 | 9 | |
| TCGA | GINS4 | 84296 | 38 | 21 | 37 |
Total number of gains: 147; Total number of losses: 75; Total Number of normals: 266.
Somatic mutations of GINS4:
Generating mutation plots.
Highly correlated genes for GINS4:
Showing top 20/1232 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GINS4 | CKAP2L | 0.849068 | 4 | 0 | 4 |
| GINS4 | DEPDC1B | 0.84393 | 3 | 0 | 3 |
| GINS4 | EME1 | 0.833553 | 4 | 0 | 4 |
| GINS4 | CDCA2 | 0.8152 | 5 | 0 | 4 |
| GINS4 | KNSTRN | 0.809106 | 3 | 0 | 3 |
| GINS4 | CYP27C1 | 0.78891 | 3 | 0 | 3 |
| GINS4 | IQGAP3 | 0.78335 | 3 | 0 | 3 |
| GINS4 | PSMG3 | 0.781583 | 3 | 0 | 3 |
| GINS4 | TTL | 0.779724 | 3 | 0 | 3 |
| GINS4 | HJURP | 0.765892 | 8 | 0 | 7 |
| GINS4 | MTFR2 | 0.762402 | 3 | 0 | 3 |
| GINS4 | ABCA12 | 0.761678 | 3 | 0 | 3 |
| GINS4 | SGPP1 | 0.743977 | 3 | 0 | 3 |
| GINS4 | AJUBA | 0.742936 | 3 | 0 | 3 |
| GINS4 | C16orf74 | 0.740567 | 4 | 0 | 4 |
| GINS4 | XPR1 | 0.733442 | 3 | 0 | 3 |
| GINS4 | AP1S3 | 0.733298 | 3 | 0 | 3 |
| GINS4 | ARL13B | 0.732661 | 3 | 0 | 3 |
| GINS4 | PKMYT1 | 0.72856 | 7 | 0 | 7 |
| GINS4 | CENPW | 0.727506 | 5 | 0 | 5 |
For details and further investigation, click here
