| Full name: cytochrome P450 family 3 subfamily A member 5 | Alias Symbol: PCN3|P450PCN3|CP35 | ||
| Type: protein-coding gene | Cytoband: 7q22.1 | ||
| Entrez ID: 1577 | HGNC ID: HGNC:2638 | Ensembl Gene: ENSG00000106258 | OMIM ID: 605325 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP3A5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP3A5 | 1577 | 214235_at | -2.1676 | 0.0552 | |
| GSE20347 | CYP3A5 | 1577 | 214235_at | -1.7973 | 0.0002 | |
| GSE23400 | CYP3A5 | 1577 | 214235_at | -1.4063 | 0.0000 | |
| GSE26886 | CYP3A5 | 1577 | 214235_at | -3.0893 | 0.0000 | |
| GSE29001 | CYP3A5 | 1577 | 214235_at | -3.2151 | 0.0000 | |
| GSE38129 | CYP3A5 | 1577 | 214234_s_at | -1.9737 | 0.0000 | |
| GSE45670 | CYP3A5 | 1577 | 205765_at | -1.5582 | 0.0182 | |
| GSE53622 | CYP3A5 | 1577 | 34489 | -2.1201 | 0.0000 | |
| GSE53624 | CYP3A5 | 1577 | 105261 | -3.8859 | 0.0000 | |
| GSE63941 | CYP3A5 | 1577 | 214234_s_at | 0.4204 | 0.6367 | |
| GSE77861 | CYP3A5 | 1577 | 214234_s_at | -2.8958 | 0.0017 | |
| GSE97050 | CYP3A5 | 1577 | A_33_P3249746 | -0.2789 | 0.2675 | |
| SRP007169 | CYP3A5 | 1577 | RNAseq | -4.2178 | 0.0000 | |
| SRP008496 | CYP3A5 | 1577 | RNAseq | -4.3044 | 0.0000 | |
| SRP064894 | CYP3A5 | 1577 | RNAseq | -3.7651 | 0.0000 | |
| SRP133303 | CYP3A5 | 1577 | RNAseq | -2.3055 | 0.0000 | |
| SRP159526 | CYP3A5 | 1577 | RNAseq | -3.3739 | 0.0002 | |
| SRP193095 | CYP3A5 | 1577 | RNAseq | -1.8699 | 0.0000 | |
| SRP219564 | CYP3A5 | 1577 | RNAseq | -3.7430 | 0.0001 | |
| TCGA | CYP3A5 | 1577 | RNAseq | -1.6828 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 17.
Survival by CYP3A5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP3A5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP3A5 | 1577 | 13 | 0 | 17 | |
| GSE20123 | CYP3A5 | 1577 | 13 | 0 | 17 | |
| GSE43470 | CYP3A5 | 1577 | 6 | 1 | 36 | |
| GSE46452 | CYP3A5 | 1577 | 11 | 1 | 47 | |
| GSE47630 | CYP3A5 | 1577 | 8 | 3 | 29 | |
| GSE54993 | CYP3A5 | 1577 | 1 | 9 | 60 | |
| GSE54994 | CYP3A5 | 1577 | 15 | 4 | 34 | |
| GSE60625 | CYP3A5 | 1577 | 0 | 0 | 11 | |
| GSE74703 | CYP3A5 | 1577 | 6 | 1 | 29 | |
| GSE74704 | CYP3A5 | 1577 | 9 | 0 | 11 | |
| TCGA | CYP3A5 | 1577 | 53 | 5 | 38 |
Total number of gains: 135; Total number of losses: 24; Total Number of normals: 329.
Somatic mutations of CYP3A5:
Generating mutation plots.
Highly correlated genes for CYP3A5:
Showing top 20/1079 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP3A5 | CYP3A7 | 0.955948 | 3 | 0 | 3 |
| CYP3A5 | EPS8L2 | 0.827161 | 11 | 0 | 11 |
| CYP3A5 | VSIG10L | 0.820712 | 7 | 0 | 7 |
| CYP3A5 | RAET1E | 0.808599 | 7 | 0 | 7 |
| CYP3A5 | CES2 | 0.80264 | 9 | 0 | 9 |
| CYP3A5 | SIM2 | 0.802039 | 10 | 0 | 10 |
| CYP3A5 | SCNN1B | 0.80172 | 12 | 0 | 11 |
| CYP3A5 | ECM1 | 0.797118 | 11 | 0 | 11 |
| CYP3A5 | SPINK7 | 0.796452 | 7 | 0 | 7 |
| CYP3A5 | PADI1 | 0.795022 | 8 | 0 | 8 |
| CYP3A5 | RHCG | 0.794319 | 11 | 0 | 11 |
| CYP3A5 | CXCR2 | 0.793332 | 10 | 0 | 10 |
| CYP3A5 | BLNK | 0.79252 | 10 | 0 | 10 |
| CYP3A5 | C5orf66-AS1 | 0.792392 | 6 | 0 | 6 |
| CYP3A5 | SNORA68 | 0.791364 | 4 | 0 | 4 |
| CYP3A5 | NCR1 | 0.789339 | 3 | 0 | 3 |
| CYP3A5 | KLF8 | 0.789044 | 10 | 0 | 10 |
| CYP3A5 | PTK6 | 0.788671 | 11 | 0 | 11 |
| CYP3A5 | SDCBP2 | 0.78792 | 3 | 0 | 3 |
| CYP3A5 | CLCA4 | 0.786821 | 13 | 0 | 12 |
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