| Full name: creatine kinase, mitochondrial 2 | Alias Symbol: SMTCK | ||
| Type: protein-coding gene | Cytoband: 5q14.1 | ||
| Entrez ID: 1160 | HGNC ID: HGNC:1996 | Ensembl Gene: ENSG00000131730 | OMIM ID: 123295 |
| Drug and gene relationship at DGIdb | |||
Expression of CKMT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CKMT2 | 1160 | 205295_at | -0.9618 | 0.2610 | |
| GSE20347 | CKMT2 | 1160 | 205295_at | -0.3061 | 0.0028 | |
| GSE23400 | CKMT2 | 1160 | 205295_at | -0.2241 | 0.0000 | |
| GSE26886 | CKMT2 | 1160 | 205295_at | -0.1433 | 0.2888 | |
| GSE29001 | CKMT2 | 1160 | 205295_at | -0.4142 | 0.0223 | |
| GSE38129 | CKMT2 | 1160 | 205295_at | -0.8990 | 0.0008 | |
| GSE45670 | CKMT2 | 1160 | 205295_at | -0.7452 | 0.0000 | |
| GSE53622 | CKMT2 | 1160 | 7917 | -2.1080 | 0.0000 | |
| GSE53624 | CKMT2 | 1160 | 7917 | -2.1625 | 0.0000 | |
| GSE63941 | CKMT2 | 1160 | 205295_at | 0.1342 | 0.4564 | |
| GSE77861 | CKMT2 | 1160 | 205295_at | -0.1798 | 0.0915 | |
| GSE97050 | CKMT2 | 1160 | A_23_P144778 | -1.2152 | 0.0762 | |
| SRP064894 | CKMT2 | 1160 | RNAseq | -0.4118 | 0.3886 | |
| SRP133303 | CKMT2 | 1160 | RNAseq | -0.0307 | 0.9209 | |
| SRP159526 | CKMT2 | 1160 | RNAseq | -0.9817 | 0.1477 | |
| SRP193095 | CKMT2 | 1160 | RNAseq | -0.5868 | 0.0263 | |
| SRP219564 | CKMT2 | 1160 | RNAseq | -2.0264 | 0.0731 | |
| TCGA | CKMT2 | 1160 | RNAseq | -3.5361 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by CKMT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CKMT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CKMT2 | 1160 | 1 | 13 | 16 | |
| GSE20123 | CKMT2 | 1160 | 1 | 13 | 16 | |
| GSE43470 | CKMT2 | 1160 | 1 | 11 | 31 | |
| GSE46452 | CKMT2 | 1160 | 0 | 28 | 31 | |
| GSE47630 | CKMT2 | 1160 | 1 | 19 | 20 | |
| GSE54993 | CKMT2 | 1160 | 8 | 1 | 61 | |
| GSE54994 | CKMT2 | 1160 | 2 | 18 | 33 | |
| GSE60625 | CKMT2 | 1160 | 0 | 0 | 11 | |
| GSE74703 | CKMT2 | 1160 | 1 | 7 | 28 | |
| GSE74704 | CKMT2 | 1160 | 1 | 6 | 13 | |
| TCGA | CKMT2 | 1160 | 5 | 49 | 42 |
Total number of gains: 21; Total number of losses: 165; Total Number of normals: 302.
Somatic mutations of CKMT2:
Generating mutation plots.
Highly correlated genes for CKMT2:
Showing top 20/1037 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CKMT2 | SORCS1 | 0.861703 | 4 | 0 | 4 |
| CKMT2 | ASB5 | 0.829661 | 5 | 0 | 5 |
| CKMT2 | CLEC3B | 0.817763 | 3 | 0 | 3 |
| CKMT2 | SLMAP | 0.815677 | 5 | 0 | 5 |
| CKMT2 | DACT3 | 0.812671 | 4 | 0 | 4 |
| CKMT2 | NEGR1 | 0.810452 | 5 | 0 | 5 |
| CKMT2 | CASQ2 | 0.808806 | 9 | 0 | 9 |
| CKMT2 | STBD1 | 0.804231 | 3 | 0 | 3 |
| CKMT2 | RAB9B | 0.803601 | 5 | 0 | 5 |
| CKMT2 | ANGPTL1 | 0.795712 | 6 | 0 | 6 |
| CKMT2 | CYP21A2 | 0.792615 | 3 | 0 | 3 |
| CKMT2 | MAMDC2 | 0.788935 | 5 | 0 | 5 |
| CKMT2 | MYOC | 0.783543 | 9 | 0 | 9 |
| CKMT2 | PI16 | 0.781308 | 5 | 0 | 5 |
| CKMT2 | FAM124A | 0.778047 | 3 | 0 | 3 |
| CKMT2 | PPP1R12B | 0.770255 | 9 | 0 | 9 |
| CKMT2 | SMIM10 | 0.768061 | 4 | 0 | 4 |
| CKMT2 | PARD3B | 0.766691 | 5 | 0 | 5 |
| CKMT2 | TMOD1 | 0.757692 | 7 | 0 | 6 |
| CKMT2 | EIF4E3 | 0.755601 | 6 | 0 | 6 |
For details and further investigation, click here
