| Full name: dopamine beta-hydroxylase | Alias Symbol: DBM | ||
| Type: protein-coding gene | Cytoband: 9q34.2 | ||
| Entrez ID: 1621 | HGNC ID: HGNC:2689 | Ensembl Gene: ENSG00000123454 | OMIM ID: 609312 |
| Drug and gene relationship at DGIdb | |||
Expression of DBH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DBH | 1621 | 206450_at | -0.0093 | 0.9766 | |
| GSE20347 | DBH | 1621 | 206450_at | -0.0002 | 0.9989 | |
| GSE23400 | DBH | 1621 | 206450_at | -0.0778 | 0.0195 | |
| GSE26886 | DBH | 1621 | 206450_at | -0.2280 | 0.1820 | |
| GSE29001 | DBH | 1621 | 206450_at | -0.1693 | 0.2520 | |
| GSE38129 | DBH | 1621 | 206450_at | -0.0596 | 0.4924 | |
| GSE45670 | DBH | 1621 | 206450_at | -0.0272 | 0.7899 | |
| GSE53622 | DBH | 1621 | 3282 | 0.0674 | 0.6630 | |
| GSE53624 | DBH | 1621 | 3282 | -0.1490 | 0.2681 | |
| GSE63941 | DBH | 1621 | 206450_at | 0.0088 | 0.9667 | |
| GSE77861 | DBH | 1621 | 206450_at | -0.1247 | 0.3250 | |
| TCGA | DBH | 1621 | RNAseq | -1.4056 | 0.0110 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by DBH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DBH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DBH | 1621 | 5 | 7 | 18 | |
| GSE20123 | DBH | 1621 | 5 | 7 | 18 | |
| GSE43470 | DBH | 1621 | 4 | 7 | 32 | |
| GSE46452 | DBH | 1621 | 6 | 13 | 40 | |
| GSE47630 | DBH | 1621 | 4 | 15 | 21 | |
| GSE54993 | DBH | 1621 | 3 | 3 | 64 | |
| GSE54994 | DBH | 1621 | 12 | 9 | 32 | |
| GSE60625 | DBH | 1621 | 0 | 0 | 11 | |
| GSE74703 | DBH | 1621 | 4 | 5 | 27 | |
| GSE74704 | DBH | 1621 | 3 | 5 | 12 | |
| TCGA | DBH | 1621 | 28 | 26 | 42 |
Total number of gains: 74; Total number of losses: 97; Total Number of normals: 317.
Somatic mutations of DBH:
Generating mutation plots.
Highly correlated genes for DBH:
Showing top 20/333 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DBH | PHOX2A | 0.7098 | 4 | 0 | 3 |
| DBH | FGF3 | 0.691767 | 3 | 0 | 3 |
| DBH | NKAIN1 | 0.680093 | 3 | 0 | 3 |
| DBH | SHOX | 0.669023 | 4 | 0 | 3 |
| DBH | NOVA2 | 0.668998 | 4 | 0 | 3 |
| DBH | EIF4A2 | 0.663314 | 3 | 0 | 3 |
| DBH | LIM2 | 0.657816 | 3 | 0 | 3 |
| DBH | RNF167 | 0.654795 | 3 | 0 | 3 |
| DBH | CCR4 | 0.648595 | 4 | 0 | 3 |
| DBH | DBP | 0.648287 | 4 | 0 | 4 |
| DBH | LYPLA2 | 0.648253 | 3 | 0 | 3 |
| DBH | SHCBP1L | 0.642035 | 3 | 0 | 3 |
| DBH | SLC22A13 | 0.638812 | 4 | 0 | 4 |
| DBH | HIF3A | 0.636221 | 3 | 0 | 3 |
| DBH | FAM153A | 0.630581 | 4 | 0 | 3 |
| DBH | CAMK2B | 0.625378 | 6 | 0 | 5 |
| DBH | MUC6 | 0.624111 | 3 | 0 | 3 |
| DBH | G6PC2 | 0.623456 | 5 | 0 | 5 |
| DBH | CXCR1 | 0.62278 | 4 | 0 | 3 |
| DBH | KIF12 | 0.619317 | 3 | 0 | 3 |
For details and further investigation, click here
