| Full name: eukaryotic translation initiation factor 4A2 | Alias Symbol: DDX2B|EIF4A|BM-010 | ||
| Type: protein-coding gene | Cytoband: 3q27.3 | ||
| Entrez ID: 1974 | HGNC ID: HGNC:3284 | Ensembl Gene: ENSG00000156976 | OMIM ID: 601102 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of EIF4A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF4A2 | 1974 | 1556350_a_at | 0.0577 | 0.7938 | |
| GSE26886 | EIF4A2 | 1974 | 1556350_a_at | 0.0733 | 0.5594 | |
| GSE45670 | EIF4A2 | 1974 | 1556350_a_at | 0.0259 | 0.8249 | |
| GSE53622 | EIF4A2 | 1974 | 129016 | -0.0945 | 0.1980 | |
| GSE53624 | EIF4A2 | 1974 | 129016 | -0.0099 | 0.8649 | |
| GSE63941 | EIF4A2 | 1974 | 1556350_a_at | 0.2832 | 0.3410 | |
| GSE77861 | EIF4A2 | 1974 | 1556350_a_at | -0.0632 | 0.4939 | |
| GSE97050 | EIF4A2 | 1974 | A_23_P121250 | -0.3374 | 0.2268 | |
| SRP007169 | EIF4A2 | 1974 | RNAseq | -0.1514 | 0.6089 | |
| SRP008496 | EIF4A2 | 1974 | RNAseq | 0.5015 | 0.0616 | |
| SRP064894 | EIF4A2 | 1974 | RNAseq | -0.1505 | 0.4238 | |
| SRP133303 | EIF4A2 | 1974 | RNAseq | 0.3015 | 0.1560 | |
| SRP159526 | EIF4A2 | 1974 | RNAseq | 0.3881 | 0.3573 | |
| SRP193095 | EIF4A2 | 1974 | RNAseq | -0.1886 | 0.1604 | |
| SRP219564 | EIF4A2 | 1974 | RNAseq | -0.1660 | 0.5741 | |
| TCGA | EIF4A2 | 1974 | RNAseq | -0.0316 | 0.4217 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EIF4A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF4A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF4A2 | 1974 | 24 | 0 | 6 | |
| GSE20123 | EIF4A2 | 1974 | 24 | 0 | 6 | |
| GSE43470 | EIF4A2 | 1974 | 23 | 0 | 20 | |
| GSE46452 | EIF4A2 | 1974 | 19 | 1 | 39 | |
| GSE47630 | EIF4A2 | 1974 | 27 | 2 | 11 | |
| GSE54993 | EIF4A2 | 1974 | 1 | 19 | 50 | |
| GSE54994 | EIF4A2 | 1974 | 40 | 0 | 13 | |
| GSE60625 | EIF4A2 | 1974 | 0 | 6 | 5 | |
| GSE74703 | EIF4A2 | 1974 | 20 | 0 | 16 | |
| GSE74704 | EIF4A2 | 1974 | 16 | 0 | 4 | |
| TCGA | EIF4A2 | 1974 | 77 | 0 | 19 |
Total number of gains: 271; Total number of losses: 28; Total Number of normals: 189.
Somatic mutations of EIF4A2:
Generating mutation plots.
Highly correlated genes for EIF4A2:
Showing top 20/35 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF4A2 | XYLB | 0.67409 | 3 | 0 | 3 |
| EIF4A2 | MYH3 | 0.669285 | 3 | 0 | 3 |
| EIF4A2 | GET4 | 0.66734 | 3 | 0 | 3 |
| EIF4A2 | FCHO1 | 0.663924 | 3 | 0 | 3 |
| EIF4A2 | DBH | 0.663314 | 3 | 0 | 3 |
| EIF4A2 | WDR27 | 0.646287 | 3 | 0 | 3 |
| EIF4A2 | ARHGAP4 | 0.645243 | 3 | 0 | 3 |
| EIF4A2 | MTSS1 | 0.642106 | 3 | 0 | 3 |
| EIF4A2 | C8orf44 | 0.639308 | 4 | 0 | 4 |
| EIF4A2 | IBA57 | 0.636091 | 3 | 0 | 3 |
| EIF4A2 | IQCC | 0.634433 | 4 | 0 | 3 |
| EIF4A2 | SRP19 | 0.622825 | 3 | 0 | 3 |
| EIF4A2 | TMEM65 | 0.60929 | 3 | 0 | 3 |
| EIF4A2 | ZNF778 | 0.606945 | 3 | 0 | 3 |
| EIF4A2 | ZNF280B | 0.59966 | 3 | 0 | 3 |
| EIF4A2 | HTR7 | 0.596844 | 4 | 0 | 3 |
| EIF4A2 | MDH1 | 0.593216 | 5 | 0 | 4 |
| EIF4A2 | IBSP | 0.590997 | 3 | 0 | 3 |
| EIF4A2 | BCCIP | 0.584056 | 4 | 0 | 3 |
| EIF4A2 | RPS11 | 0.570094 | 4 | 0 | 3 |
For details and further investigation, click here
