| Full name: C-C motif chemokine receptor 4 | Alias Symbol: CC-CKR-4|CMKBR4|CKR4|k5-5|ChemR13|CD194 | ||
| Type: protein-coding gene | Cytoband: 3p22.3 | ||
| Entrez ID: 1233 | HGNC ID: HGNC:1605 | Ensembl Gene: ENSG00000183813 | OMIM ID: 604836 |
| Drug and gene relationship at DGIdb | |||
CCR4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of CCR4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCR4 | 1233 | 208376_at | -0.1223 | 0.7146 | |
| GSE20347 | CCR4 | 1233 | 208376_at | 0.1037 | 0.4011 | |
| GSE23400 | CCR4 | 1233 | 208376_at | -0.1297 | 0.0040 | |
| GSE26886 | CCR4 | 1233 | 208376_at | -0.2204 | 0.0620 | |
| GSE29001 | CCR4 | 1233 | 208376_at | -0.2265 | 0.2629 | |
| GSE38129 | CCR4 | 1233 | 208376_at | -0.1403 | 0.1164 | |
| GSE45670 | CCR4 | 1233 | 208376_at | 0.1241 | 0.1728 | |
| GSE53622 | CCR4 | 1233 | 2420 | -0.1467 | 0.5925 | |
| GSE53624 | CCR4 | 1233 | 2420 | -0.5285 | 0.0050 | |
| GSE63941 | CCR4 | 1233 | 208376_at | -0.0974 | 0.6031 | |
| GSE77861 | CCR4 | 1233 | 208376_at | 0.0003 | 0.9980 | |
| GSE97050 | CCR4 | 1233 | A_23_P72989 | 0.5095 | 0.1670 | |
| SRP007169 | CCR4 | 1233 | RNAseq | 0.3609 | 0.5608 | |
| SRP133303 | CCR4 | 1233 | RNAseq | 0.1239 | 0.4132 | |
| SRP159526 | CCR4 | 1233 | RNAseq | -0.9523 | 0.2568 | |
| SRP193095 | CCR4 | 1233 | RNAseq | -0.0077 | 0.9601 | |
| SRP219564 | CCR4 | 1233 | RNAseq | 0.1610 | 0.7884 | |
| TCGA | CCR4 | 1233 | RNAseq | 0.0547 | 0.8916 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CCR4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCR4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCR4 | 1233 | 0 | 18 | 12 | |
| GSE20123 | CCR4 | 1233 | 0 | 18 | 12 | |
| GSE43470 | CCR4 | 1233 | 1 | 19 | 23 | |
| GSE46452 | CCR4 | 1233 | 2 | 17 | 40 | |
| GSE47630 | CCR4 | 1233 | 1 | 25 | 14 | |
| GSE54993 | CCR4 | 1233 | 6 | 3 | 61 | |
| GSE54994 | CCR4 | 1233 | 1 | 32 | 20 | |
| GSE60625 | CCR4 | 1233 | 5 | 0 | 6 | |
| GSE74703 | CCR4 | 1233 | 1 | 16 | 19 | |
| GSE74704 | CCR4 | 1233 | 0 | 12 | 8 | |
| TCGA | CCR4 | 1233 | 1 | 69 | 26 |
Total number of gains: 18; Total number of losses: 229; Total Number of normals: 241.
Somatic mutations of CCR4:
Generating mutation plots.
Highly correlated genes for CCR4:
Showing top 20/656 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCR4 | GPR171 | 0.814031 | 3 | 0 | 3 |
| CCR4 | CD96 | 0.801766 | 3 | 0 | 3 |
| CCR4 | CD3D | 0.80053 | 3 | 0 | 3 |
| CCR4 | ITK | 0.788367 | 4 | 0 | 4 |
| CCR4 | LCK | 0.783315 | 3 | 0 | 3 |
| CCR4 | FCRL3 | 0.774381 | 3 | 0 | 3 |
| CCR4 | SAMD3 | 0.769365 | 3 | 0 | 3 |
| CCR4 | TNFAIP8L2 | 0.754367 | 4 | 0 | 4 |
| CCR4 | C16orf54 | 0.751777 | 3 | 0 | 3 |
| CCR4 | EVI2B | 0.751515 | 3 | 0 | 3 |
| CCR4 | CD37 | 0.751081 | 4 | 0 | 4 |
| CCR4 | MUC6 | 0.746073 | 4 | 0 | 4 |
| CCR4 | CORO1A | 0.744353 | 4 | 0 | 4 |
| CCR4 | SLAMF7 | 0.720221 | 3 | 0 | 3 |
| CCR4 | MAPK11 | 0.719274 | 3 | 0 | 3 |
| CCR4 | LCP1 | 0.71529 | 3 | 0 | 3 |
| CCR4 | KLRB1 | 0.712194 | 4 | 0 | 3 |
| CCR4 | RGS18 | 0.711532 | 3 | 0 | 3 |
| CCR4 | OVOL3 | 0.711525 | 4 | 0 | 4 |
| CCR4 | GIMAP1 | 0.711459 | 3 | 0 | 3 |
For details and further investigation, click here
