| Full name: A-kinase anchoring protein 5 | Alias Symbol: AKAP75|AKAP79 | ||
| Type: protein-coding gene | Cytoband: 14q23.3 | ||
| Entrez ID: 9495 | HGNC ID: HGNC:375 | Ensembl Gene: ENSG00000179841 | OMIM ID: 604688 |
| Drug and gene relationship at DGIdb | |||
Expression of AKAP5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AKAP5 | 9495 | 230846_at | 0.0854 | 0.8405 | |
| GSE20347 | AKAP5 | 9495 | 207800_at | -0.0643 | 0.3546 | |
| GSE23400 | AKAP5 | 9495 | 207800_at | -0.1520 | 0.0000 | |
| GSE26886 | AKAP5 | 9495 | 230846_at | 0.3263 | 0.0128 | |
| GSE29001 | AKAP5 | 9495 | 207800_at | -0.0825 | 0.6749 | |
| GSE38129 | AKAP5 | 9495 | 207800_at | -0.1313 | 0.0413 | |
| GSE45670 | AKAP5 | 9495 | 230846_at | 0.0073 | 0.9638 | |
| GSE53622 | AKAP5 | 9495 | 81740 | 0.2724 | 0.0793 | |
| GSE53624 | AKAP5 | 9495 | 81740 | 0.5715 | 0.0000 | |
| GSE63941 | AKAP5 | 9495 | 230846_at | 0.2290 | 0.3464 | |
| GSE77861 | AKAP5 | 9495 | 230846_at | -0.0267 | 0.8386 | |
| GSE97050 | AKAP5 | 9495 | A_33_P3394380 | 0.3255 | 0.2272 | |
| SRP007169 | AKAP5 | 9495 | RNAseq | 0.7439 | 0.2075 | |
| SRP008496 | AKAP5 | 9495 | RNAseq | 1.1620 | 0.0155 | |
| SRP064894 | AKAP5 | 9495 | RNAseq | 0.3089 | 0.1899 | |
| SRP133303 | AKAP5 | 9495 | RNAseq | 0.2521 | 0.1938 | |
| SRP159526 | AKAP5 | 9495 | RNAseq | 0.3939 | 0.3037 | |
| SRP193095 | AKAP5 | 9495 | RNAseq | 0.4024 | 0.0008 | |
| SRP219564 | AKAP5 | 9495 | RNAseq | 1.1128 | 0.0142 | |
| TCGA | AKAP5 | 9495 | RNAseq | 0.2079 | 0.2352 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by AKAP5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AKAP5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AKAP5 | 9495 | 7 | 3 | 20 | |
| GSE20123 | AKAP5 | 9495 | 7 | 3 | 20 | |
| GSE43470 | AKAP5 | 9495 | 8 | 2 | 33 | |
| GSE46452 | AKAP5 | 9495 | 16 | 3 | 40 | |
| GSE47630 | AKAP5 | 9495 | 11 | 9 | 20 | |
| GSE54993 | AKAP5 | 9495 | 3 | 9 | 58 | |
| GSE54994 | AKAP5 | 9495 | 18 | 5 | 30 | |
| GSE60625 | AKAP5 | 9495 | 0 | 2 | 9 | |
| GSE74703 | AKAP5 | 9495 | 7 | 2 | 27 | |
| GSE74704 | AKAP5 | 9495 | 3 | 2 | 15 | |
| TCGA | AKAP5 | 9495 | 32 | 14 | 50 |
Total number of gains: 112; Total number of losses: 54; Total Number of normals: 322.
Somatic mutations of AKAP5:
Generating mutation plots.
Highly correlated genes for AKAP5:
Showing top 20/639 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AKAP5 | ANKFY1 | 0.796396 | 3 | 0 | 3 |
| AKAP5 | ZNF584 | 0.729358 | 3 | 0 | 3 |
| AKAP5 | SLFN11 | 0.728457 | 4 | 0 | 4 |
| AKAP5 | DHX37 | 0.722654 | 3 | 0 | 3 |
| AKAP5 | GUCY1A2 | 0.711317 | 3 | 0 | 3 |
| AKAP5 | CCDC7 | 0.708312 | 5 | 0 | 5 |
| AKAP5 | STAT2 | 0.705684 | 5 | 0 | 4 |
| AKAP5 | ZNF358 | 0.703232 | 4 | 0 | 4 |
| AKAP5 | CIC | 0.702262 | 3 | 0 | 3 |
| AKAP5 | TSNARE1 | 0.7003 | 3 | 0 | 3 |
| AKAP5 | DCC | 0.696362 | 4 | 0 | 4 |
| AKAP5 | CSF1R | 0.69388 | 3 | 0 | 3 |
| AKAP5 | HAVCR2 | 0.690286 | 4 | 0 | 4 |
| AKAP5 | GDF5 | 0.686223 | 6 | 0 | 4 |
| AKAP5 | SCNN1G | 0.685833 | 4 | 0 | 4 |
| AKAP5 | ATP8B2 | 0.68397 | 4 | 0 | 3 |
| AKAP5 | PRDM11 | 0.682592 | 4 | 0 | 4 |
| AKAP5 | BRINP2 | 0.676088 | 4 | 0 | 4 |
| AKAP5 | SPI1 | 0.669818 | 5 | 0 | 5 |
| AKAP5 | TFEC | 0.667406 | 5 | 0 | 4 |
For details and further investigation, click here
