| Full name: dynactin subunit 3 | Alias Symbol: DCTN-22 | ||
| Type: protein-coding gene | Cytoband: 9p13.3 | ||
| Entrez ID: 11258 | HGNC ID: HGNC:2713 | Ensembl Gene: ENSG00000137100 | OMIM ID: 607387 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DCTN3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DCTN3 | 11258 | 204246_s_at | -0.7952 | 0.1183 | |
| GSE20347 | DCTN3 | 11258 | 204246_s_at | -1.0155 | 0.0000 | |
| GSE23400 | DCTN3 | 11258 | 204246_s_at | -0.4395 | 0.0000 | |
| GSE26886 | DCTN3 | 11258 | 204246_s_at | -0.8304 | 0.0000 | |
| GSE29001 | DCTN3 | 11258 | 204246_s_at | -0.7179 | 0.0512 | |
| GSE38129 | DCTN3 | 11258 | 204246_s_at | -0.7456 | 0.0000 | |
| GSE45670 | DCTN3 | 11258 | 204246_s_at | -0.3855 | 0.0085 | |
| GSE53622 | DCTN3 | 11258 | 18946 | -0.7398 | 0.0000 | |
| GSE53624 | DCTN3 | 11258 | 18946 | -0.6264 | 0.0000 | |
| GSE63941 | DCTN3 | 11258 | 204246_s_at | -0.3760 | 0.3693 | |
| GSE77861 | DCTN3 | 11258 | 204246_s_at | -0.8315 | 0.0605 | |
| GSE97050 | DCTN3 | 11258 | A_23_P158024 | -0.3232 | 0.1864 | |
| SRP007169 | DCTN3 | 11258 | RNAseq | -1.5005 | 0.0018 | |
| SRP008496 | DCTN3 | 11258 | RNAseq | -1.6640 | 0.0000 | |
| SRP064894 | DCTN3 | 11258 | RNAseq | -0.3651 | 0.1412 | |
| SRP133303 | DCTN3 | 11258 | RNAseq | -0.6051 | 0.0000 | |
| SRP159526 | DCTN3 | 11258 | RNAseq | -1.0098 | 0.0000 | |
| SRP193095 | DCTN3 | 11258 | RNAseq | -0.8786 | 0.0000 | |
| SRP219564 | DCTN3 | 11258 | RNAseq | -0.1592 | 0.6750 | |
| TCGA | DCTN3 | 11258 | RNAseq | -0.0484 | 0.4105 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by DCTN3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DCTN3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DCTN3 | 11258 | 4 | 13 | 13 | |
| GSE20123 | DCTN3 | 11258 | 4 | 13 | 13 | |
| GSE43470 | DCTN3 | 11258 | 3 | 10 | 30 | |
| GSE46452 | DCTN3 | 11258 | 6 | 15 | 38 | |
| GSE47630 | DCTN3 | 11258 | 1 | 20 | 19 | |
| GSE54993 | DCTN3 | 11258 | 6 | 0 | 64 | |
| GSE54994 | DCTN3 | 11258 | 6 | 12 | 35 | |
| GSE60625 | DCTN3 | 11258 | 0 | 0 | 11 | |
| GSE74703 | DCTN3 | 11258 | 2 | 7 | 27 | |
| GSE74704 | DCTN3 | 11258 | 0 | 11 | 9 | |
| TCGA | DCTN3 | 11258 | 17 | 44 | 35 |
Total number of gains: 49; Total number of losses: 145; Total Number of normals: 294.
Somatic mutations of DCTN3:
Generating mutation plots.
Highly correlated genes for DCTN3:
Showing top 20/1503 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DCTN3 | GMPPB | 0.743527 | 3 | 0 | 3 |
| DCTN3 | TMEM19 | 0.742991 | 4 | 0 | 4 |
| DCTN3 | PGK1 | 0.736381 | 3 | 0 | 3 |
| DCTN3 | GNGT2 | 0.731977 | 3 | 0 | 3 |
| DCTN3 | TAF9B | 0.725703 | 3 | 0 | 3 |
| DCTN3 | BRK1 | 0.723688 | 7 | 0 | 6 |
| DCTN3 | TMEM219 | 0.72295 | 4 | 0 | 4 |
| DCTN3 | RHOA | 0.722273 | 12 | 0 | 11 |
| DCTN3 | SNORA68 | 0.717323 | 4 | 0 | 4 |
| DCTN3 | ARPC1A | 0.716981 | 3 | 0 | 3 |
| DCTN3 | SLC12A6 | 0.714236 | 3 | 0 | 3 |
| DCTN3 | EIF1AY | 0.712926 | 3 | 0 | 3 |
| DCTN3 | RABIF | 0.711944 | 3 | 0 | 3 |
| DCTN3 | NAGK | 0.708838 | 11 | 0 | 11 |
| DCTN3 | SLC17A5 | 0.707312 | 5 | 0 | 4 |
| DCTN3 | FCHO2 | 0.704063 | 7 | 0 | 7 |
| DCTN3 | PPP1R7 | 0.703249 | 11 | 0 | 9 |
| DCTN3 | SLU7 | 0.699555 | 4 | 0 | 4 |
| DCTN3 | PXMP4 | 0.699292 | 3 | 0 | 3 |
| DCTN3 | ZNF844 | 0.698959 | 6 | 0 | 6 |
For details and further investigation, click here
