| Full name: protein phosphatase 1 regulatory subunit 7 | Alias Symbol: sds22 | ||
| Type: protein-coding gene | Cytoband: 2q37.3 | ||
| Entrez ID: 5510 | HGNC ID: HGNC:9295 | Ensembl Gene: ENSG00000115685 | OMIM ID: 602877 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PPP1R7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP1R7 | 5510 | 213465_s_at | -1.2371 | 0.0264 | |
| GSE20347 | PPP1R7 | 5510 | 213465_s_at | -1.4184 | 0.0000 | |
| GSE23400 | PPP1R7 | 5510 | 213465_s_at | -0.7782 | 0.0000 | |
| GSE26886 | PPP1R7 | 5510 | 201214_s_at | -1.2576 | 0.0000 | |
| GSE29001 | PPP1R7 | 5510 | 201214_s_at | -0.8854 | 0.0814 | |
| GSE38129 | PPP1R7 | 5510 | 213465_s_at | -1.0381 | 0.0000 | |
| GSE45670 | PPP1R7 | 5510 | 213465_s_at | -0.5611 | 0.0005 | |
| GSE53622 | PPP1R7 | 5510 | 139096 | -0.4884 | 0.0000 | |
| GSE53624 | PPP1R7 | 5510 | 139096 | -0.6832 | 0.0000 | |
| GSE63941 | PPP1R7 | 5510 | 213465_s_at | 0.0633 | 0.8897 | |
| GSE77861 | PPP1R7 | 5510 | 213465_s_at | -0.9356 | 0.0032 | |
| GSE97050 | PPP1R7 | 5510 | A_23_P154199 | -0.1170 | 0.6015 | |
| SRP007169 | PPP1R7 | 5510 | RNAseq | -1.4453 | 0.0001 | |
| SRP008496 | PPP1R7 | 5510 | RNAseq | -1.5794 | 0.0000 | |
| SRP064894 | PPP1R7 | 5510 | RNAseq | -0.5387 | 0.0300 | |
| SRP133303 | PPP1R7 | 5510 | RNAseq | -0.3997 | 0.0033 | |
| SRP159526 | PPP1R7 | 5510 | RNAseq | -0.6766 | 0.0033 | |
| SRP193095 | PPP1R7 | 5510 | RNAseq | -1.0191 | 0.0000 | |
| SRP219564 | PPP1R7 | 5510 | RNAseq | -0.6839 | 0.0043 | |
| TCGA | PPP1R7 | 5510 | RNAseq | -0.0732 | 0.1358 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by PPP1R7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP1R7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP1R7 | 5510 | 1 | 12 | 17 | |
| GSE20123 | PPP1R7 | 5510 | 1 | 12 | 17 | |
| GSE43470 | PPP1R7 | 5510 | 1 | 9 | 33 | |
| GSE46452 | PPP1R7 | 5510 | 0 | 5 | 54 | |
| GSE47630 | PPP1R7 | 5510 | 4 | 5 | 31 | |
| GSE54993 | PPP1R7 | 5510 | 4 | 3 | 63 | |
| GSE54994 | PPP1R7 | 5510 | 8 | 9 | 36 | |
| GSE60625 | PPP1R7 | 5510 | 0 | 3 | 8 | |
| GSE74703 | PPP1R7 | 5510 | 1 | 7 | 28 | |
| GSE74704 | PPP1R7 | 5510 | 1 | 5 | 14 | |
| TCGA | PPP1R7 | 5510 | 12 | 28 | 56 |
Total number of gains: 33; Total number of losses: 98; Total Number of normals: 357.
Somatic mutations of PPP1R7:
Generating mutation plots.
Highly correlated genes for PPP1R7:
Showing top 20/1652 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP1R7 | SNORA68 | 0.879029 | 4 | 0 | 4 |
| PPP1R7 | GBP6 | 0.867516 | 4 | 0 | 4 |
| PPP1R7 | SFTA2 | 0.804903 | 4 | 0 | 4 |
| PPP1R7 | NAGK | 0.794786 | 11 | 0 | 11 |
| PPP1R7 | ZFAND2B | 0.788346 | 7 | 0 | 7 |
| PPP1R7 | TP53I3 | 0.773941 | 10 | 0 | 10 |
| PPP1R7 | CYSRT1 | 0.769501 | 6 | 0 | 6 |
| PPP1R7 | FAM214A | 0.76827 | 6 | 0 | 6 |
| PPP1R7 | GDPD3 | 0.765951 | 9 | 0 | 9 |
| PPP1R7 | CTTNBP2 | 0.761343 | 6 | 0 | 6 |
| PPP1R7 | SH3PXD2A-AS1 | 0.757682 | 4 | 0 | 4 |
| PPP1R7 | RMND5B | 0.751155 | 11 | 0 | 10 |
| PPP1R7 | SAMD5 | 0.751031 | 7 | 0 | 7 |
| PPP1R7 | KLB | 0.750477 | 6 | 0 | 6 |
| PPP1R7 | PLEKHA7 | 0.749818 | 7 | 0 | 7 |
| PPP1R7 | PMM1 | 0.749072 | 11 | 0 | 10 |
| PPP1R7 | ARPC2 | 0.747141 | 10 | 0 | 10 |
| PPP1R7 | SUMF1 | 0.745731 | 3 | 0 | 3 |
| PPP1R7 | A2ML1 | 0.745577 | 6 | 0 | 6 |
| PPP1R7 | VSIG10L | 0.745442 | 6 | 0 | 6 |
For details and further investigation, click here
