RHOA

 

Full name: ras homolog family member A Alias Symbol: RhoA|Rho12|RHOH12
Type: protein-coding gene Cytoband: 3p21.31
Entrez ID: 387 HGNC ID: HGNC:667 Ensembl Gene: ENSG00000067560 OMIM ID: 165390
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 61/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

RHOA involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04310Wnt signaling pathway
hsa04350TGF-beta signaling pathway
hsa04360Axon guidance
hsa04510Focal adhesion
hsa04520Adherens junction
hsa04530Tight junction
hsa04611Platelet activation
hsa04660T cell receptor signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04722Neurotrophin signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa04921Oxytocin signaling pathway
hsa05100Bacterial invasion of epithelial cells
hsa05130Pathogenic Escherichia coli infection
hsa05133Pertussis
hsa05152Tuberculosis
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05210Colorectal cancer

 

Expression of RHOA:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RHOA 387 200059_s_at -0.5407 0.2189
GSE20347 RHOA 387 200059_s_at -1.0937 0.0000
GSE23400 RHOA 387 200059_s_at -0.4962 0.0000
GSE26886 RHOA 387 200059_s_at -1.8848 0.0000
GSE29001 RHOA 387 200059_s_at -0.9659 0.0189
GSE38129 RHOA 387 200059_s_at -0.8050 0.0000
GSE45670 RHOA 387 200059_s_at -0.3570 0.0001
GSE53622 RHOA 387 67432 -0.5974 0.0000
GSE53624 RHOA 387 67432 -0.7747 0.0000
GSE63941 RHOA 387 200059_s_at -0.3126 0.1377
GSE77861 RHOA 387 200059_s_at -0.8648 0.0035
GSE97050 RHOA 387 A_23_P69493 -0.4874 0.1372
SRP007169 RHOA 387 RNAseq -1.9298 0.0000
SRP008496 RHOA 387 RNAseq -1.7043 0.0000
SRP064894 RHOA 387 RNAseq -0.4721 0.0002
SRP133303 RHOA 387 RNAseq -0.5416 0.0000
SRP159526 RHOA 387 RNAseq -0.7750 0.0015
SRP193095 RHOA 387 RNAseq -0.9630 0.0000
SRP219564 RHOA 387 RNAseq -0.5276 0.0616
TCGA RHOA 387 RNAseq -0.0993 0.0073

Upregulated datasets: 0; Downregulated datasets: 4.  

 

Survival by RHOA expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RHOA:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RHOA 387 0 18 12
GSE20123 RHOA 387 0 19 11
GSE43470 RHOA 387 0 18 25
GSE46452 RHOA 387 2 16 41
GSE47630 RHOA 387 1 24 15
GSE54993 RHOA 387 6 2 62
GSE54994 RHOA 387 0 36 17
GSE60625 RHOA 387 5 0 6
GSE74703 RHOA 387 0 14 22
GSE74704 RHOA 387 0 12 8
TCGA RHOA 387 0 78 18

Total number of gains: 14; Total number of losses: 237; Total Number of normals: 237.  

 

Somatic mutations of RHOA:

 

Generating mutation plots.

 

Highly correlated genes for RHOA:

 

Showing top 20/1652 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RHOACNN30.819363909
RHOABRK10.798942807
RHOASNORA680.760413404
RHOASPCS10.75492513012
RHOAGMPPB0.741712303
RHOAFBXO80.738293707
RHOASH3GLB10.73755111010
RHOAUGP20.736923908
RHOACGNL10.735124707
RHOAEPB41L30.73500711011
RHOATMEM2340.723059504
RHOASUCLG20.72257713012
RHOADCTN30.72227312011
RHOAGPD1L0.72101611011
RHOASNX30.71944812012
RHOAUBL30.71936510010
RHOACTTNBP2NL0.718713807
RHOAFAM214A0.717666606
RHOAFAM3D0.717207606
RHOALRRFIP20.7157071109

For details and further investigation, click here