| Full name: DNA damage inducible transcript 3 | Alias Symbol: CHOP10|GADD153|CHOP | ||
| Type: protein-coding gene | Cytoband: 12q13.3 | ||
| Entrez ID: 1649 | HGNC ID: HGNC:2726 | Ensembl Gene: ENSG00000175197 | OMIM ID: 126337 |
| Drug and gene relationship at DGIdb | |||
DDIT3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04210 | Apoptosis | |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD) |
Expression of DDIT3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDIT3 | 1649 | 209383_at | -0.4459 | 0.6962 | |
| GSE20347 | DDIT3 | 1649 | 209383_at | 0.7989 | 0.0000 | |
| GSE23400 | DDIT3 | 1649 | 209383_at | 0.1018 | 0.0746 | |
| GSE26886 | DDIT3 | 1649 | 209383_at | 0.6283 | 0.0029 | |
| GSE29001 | DDIT3 | 1649 | 209383_at | 0.1212 | 0.6596 | |
| GSE38129 | DDIT3 | 1649 | 209383_at | 0.6424 | 0.0002 | |
| GSE45670 | DDIT3 | 1649 | 209383_at | 0.1978 | 0.3884 | |
| GSE53622 | DDIT3 | 1649 | 40674 | 0.7127 | 0.0000 | |
| GSE53624 | DDIT3 | 1649 | 40674 | 0.8451 | 0.0000 | |
| GSE63941 | DDIT3 | 1649 | 209383_at | 0.0948 | 0.9355 | |
| GSE77861 | DDIT3 | 1649 | 209383_at | 0.6032 | 0.0037 | |
| GSE97050 | DDIT3 | 1649 | A_23_P21134 | -0.1084 | 0.7856 | |
| SRP007169 | DDIT3 | 1649 | RNAseq | 1.2599 | 0.0303 | |
| SRP008496 | DDIT3 | 1649 | RNAseq | 1.2284 | 0.0007 | |
| SRP064894 | DDIT3 | 1649 | RNAseq | 0.6271 | 0.0247 | |
| SRP133303 | DDIT3 | 1649 | RNAseq | 0.8588 | 0.0000 | |
| SRP159526 | DDIT3 | 1649 | RNAseq | 0.4334 | 0.1088 | |
| SRP193095 | DDIT3 | 1649 | RNAseq | 1.0640 | 0.0000 | |
| SRP219564 | DDIT3 | 1649 | RNAseq | 0.6566 | 0.2614 | |
| TCGA | DDIT3 | 1649 | RNAseq | 0.0564 | 0.5214 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by DDIT3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDIT3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDIT3 | 1649 | 7 | 1 | 22 | |
| GSE20123 | DDIT3 | 1649 | 7 | 0 | 23 | |
| GSE43470 | DDIT3 | 1649 | 2 | 0 | 41 | |
| GSE46452 | DDIT3 | 1649 | 8 | 1 | 50 | |
| GSE47630 | DDIT3 | 1649 | 10 | 2 | 28 | |
| GSE54993 | DDIT3 | 1649 | 0 | 5 | 65 | |
| GSE54994 | DDIT3 | 1649 | 4 | 1 | 48 | |
| GSE60625 | DDIT3 | 1649 | 0 | 0 | 11 | |
| GSE74703 | DDIT3 | 1649 | 2 | 0 | 34 | |
| GSE74704 | DDIT3 | 1649 | 5 | 0 | 15 | |
| TCGA | DDIT3 | 1649 | 14 | 10 | 72 |
Total number of gains: 59; Total number of losses: 20; Total Number of normals: 409.
Somatic mutations of DDIT3:
Generating mutation plots.
Highly correlated genes for DDIT3:
Showing top 20/607 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDIT3 | TPCN2 | 0.812962 | 3 | 0 | 3 |
| DDIT3 | SESTD1 | 0.797501 | 3 | 0 | 3 |
| DDIT3 | ANPEP | 0.778084 | 3 | 0 | 3 |
| DDIT3 | FAM168B | 0.776006 | 3 | 0 | 3 |
| DDIT3 | ERRFI1 | 0.770475 | 3 | 0 | 3 |
| DDIT3 | NHSL2 | 0.769008 | 3 | 0 | 3 |
| DDIT3 | RNF145 | 0.748901 | 3 | 0 | 3 |
| DDIT3 | CCDC124 | 0.748136 | 3 | 0 | 3 |
| DDIT3 | GGN | 0.748063 | 3 | 0 | 3 |
| DDIT3 | UBXN7 | 0.746926 | 3 | 0 | 3 |
| DDIT3 | C11orf96 | 0.745263 | 3 | 0 | 3 |
| DDIT3 | CELF1 | 0.738095 | 3 | 0 | 3 |
| DDIT3 | ALKBH6 | 0.737909 | 3 | 0 | 3 |
| DDIT3 | SSC5D | 0.737339 | 3 | 0 | 3 |
| DDIT3 | THOC1 | 0.735535 | 3 | 0 | 3 |
| DDIT3 | CNTD1 | 0.730658 | 3 | 0 | 3 |
| DDIT3 | ANTXR2 | 0.72668 | 3 | 0 | 3 |
| DDIT3 | CKB | 0.725607 | 4 | 0 | 4 |
| DDIT3 | IGSF11 | 0.723488 | 3 | 0 | 3 |
| DDIT3 | RNF13 | 0.723338 | 4 | 0 | 4 |
For details and further investigation, click here
