| Full name: two pore segment channel 2 | Alias Symbol: TPC2 | ||
| Type: protein-coding gene | Cytoband: 11q13.3 | ||
| Entrez ID: 219931 | HGNC ID: HGNC:20820 | Ensembl Gene: ENSG00000162341 | OMIM ID: 612163 |
| Drug and gene relationship at DGIdb | |||
TPCN2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04972 | Pancreatic secretion |
Expression of TPCN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TPCN2 | 219931 | 229250_at | 1.1712 | 0.3829 | |
| GSE26886 | TPCN2 | 219931 | 229250_at | 1.0454 | 0.0055 | |
| GSE45670 | TPCN2 | 219931 | 229250_at | 0.4993 | 0.1135 | |
| GSE53622 | TPCN2 | 219931 | 114833 | 1.2194 | 0.0000 | |
| GSE53624 | TPCN2 | 219931 | 114833 | 1.3093 | 0.0000 | |
| GSE63941 | TPCN2 | 219931 | 229251_s_at | 0.2754 | 0.5223 | |
| GSE77861 | TPCN2 | 219931 | 235194_at | 0.3135 | 0.1634 | |
| GSE97050 | TPCN2 | 219931 | A_33_P3264612 | 0.1002 | 0.6951 | |
| SRP008496 | TPCN2 | 219931 | RNAseq | 2.1543 | 0.0191 | |
| SRP064894 | TPCN2 | 219931 | RNAseq | 0.7711 | 0.0017 | |
| SRP133303 | TPCN2 | 219931 | RNAseq | 1.7895 | 0.0000 | |
| SRP159526 | TPCN2 | 219931 | RNAseq | 2.2715 | 0.0005 | |
| SRP193095 | TPCN2 | 219931 | RNAseq | 1.8232 | 0.0000 | |
| TCGA | TPCN2 | 219931 | RNAseq | -0.5569 | 0.0000 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by TPCN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TPCN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TPCN2 | 219931 | 14 | 2 | 14 | |
| GSE20123 | TPCN2 | 219931 | 14 | 2 | 14 | |
| GSE43470 | TPCN2 | 219931 | 14 | 3 | 26 | |
| GSE46452 | TPCN2 | 219931 | 34 | 1 | 24 | |
| GSE47630 | TPCN2 | 219931 | 20 | 1 | 19 | |
| GSE54993 | TPCN2 | 219931 | 1 | 17 | 52 | |
| GSE54994 | TPCN2 | 219931 | 26 | 3 | 24 | |
| GSE60625 | TPCN2 | 219931 | 0 | 4 | 7 | |
| GSE74703 | TPCN2 | 219931 | 11 | 2 | 23 | |
| GSE74704 | TPCN2 | 219931 | 11 | 0 | 9 | |
| TCGA | TPCN2 | 219931 | 55 | 3 | 38 |
Total number of gains: 200; Total number of losses: 38; Total Number of normals: 250.
Somatic mutations of TPCN2:
Generating mutation plots.
Highly correlated genes for TPCN2:
Showing top 20/679 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TPCN2 | GAS2L1 | 0.864763 | 3 | 0 | 3 |
| TPCN2 | DDIT3 | 0.812962 | 3 | 0 | 3 |
| TPCN2 | RPAIN | 0.777591 | 3 | 0 | 3 |
| TPCN2 | SDR39U1 | 0.766331 | 3 | 0 | 3 |
| TPCN2 | TGFBR1 | 0.756334 | 3 | 0 | 3 |
| TPCN2 | PUM1 | 0.750216 | 3 | 0 | 3 |
| TPCN2 | NEIL2 | 0.750107 | 3 | 0 | 3 |
| TPCN2 | MGAT2 | 0.746303 | 3 | 0 | 3 |
| TPCN2 | DPP9 | 0.744618 | 3 | 0 | 3 |
| TPCN2 | SPEN | 0.739464 | 3 | 0 | 3 |
| TPCN2 | ACY1 | 0.736681 | 3 | 0 | 3 |
| TPCN2 | SERPINF2 | 0.736502 | 3 | 0 | 3 |
| TPCN2 | CHST2 | 0.735619 | 4 | 0 | 3 |
| TPCN2 | ZDBF2 | 0.733108 | 3 | 0 | 3 |
| TPCN2 | CLASRP | 0.732006 | 3 | 0 | 3 |
| TPCN2 | THOC1 | 0.73092 | 4 | 0 | 3 |
| TPCN2 | RAD23A | 0.729154 | 3 | 0 | 3 |
| TPCN2 | EIF2AK4 | 0.728065 | 3 | 0 | 3 |
| TPCN2 | YES1 | 0.727102 | 3 | 0 | 3 |
| TPCN2 | PPP1R35 | 0.722546 | 3 | 0 | 3 |
For details and further investigation, click here
