| Full name: creatine kinase B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q32.33 | ||
| Entrez ID: 1152 | HGNC ID: HGNC:1991 | Ensembl Gene: ENSG00000166165 | OMIM ID: 123280 |
| Drug and gene relationship at DGIdb | |||
Expression of CKB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CKB | 1152 | 200884_at | -0.8874 | 0.4333 | |
| GSE20347 | CKB | 1152 | 200884_at | 0.1338 | 0.7121 | |
| GSE23400 | CKB | 1152 | 200884_at | -0.5225 | 0.0058 | |
| GSE26886 | CKB | 1152 | 200884_at | 0.8095 | 0.0066 | |
| GSE29001 | CKB | 1152 | 200884_at | 0.4078 | 0.3529 | |
| GSE38129 | CKB | 1152 | 200884_at | -0.7699 | 0.1120 | |
| GSE45670 | CKB | 1152 | 200884_at | -0.4880 | 0.2394 | |
| GSE53622 | CKB | 1152 | 41188 | -1.2846 | 0.0000 | |
| GSE53624 | CKB | 1152 | 41188 | -0.7376 | 0.0000 | |
| GSE63941 | CKB | 1152 | 200884_at | 1.1321 | 0.2977 | |
| GSE77861 | CKB | 1152 | 200884_at | 1.2070 | 0.0169 | |
| GSE97050 | CKB | 1152 | A_23_P25674 | -1.4120 | 0.1853 | |
| SRP007169 | CKB | 1152 | RNAseq | 0.3902 | 0.5952 | |
| SRP008496 | CKB | 1152 | RNAseq | 0.8240 | 0.2396 | |
| SRP064894 | CKB | 1152 | RNAseq | -0.9182 | 0.0064 | |
| SRP133303 | CKB | 1152 | RNAseq | -0.6018 | 0.2298 | |
| SRP159526 | CKB | 1152 | RNAseq | -0.1741 | 0.8045 | |
| SRP193095 | CKB | 1152 | RNAseq | -0.0626 | 0.8542 | |
| SRP219564 | CKB | 1152 | RNAseq | -1.4348 | 0.1897 | |
| TCGA | CKB | 1152 | RNAseq | -0.9937 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by CKB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CKB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CKB | 1152 | 12 | 3 | 15 | |
| GSE20123 | CKB | 1152 | 11 | 2 | 17 | |
| GSE43470 | CKB | 1152 | 6 | 4 | 33 | |
| GSE46452 | CKB | 1152 | 18 | 4 | 37 | |
| GSE47630 | CKB | 1152 | 10 | 8 | 22 | |
| GSE54993 | CKB | 1152 | 3 | 8 | 59 | |
| GSE54994 | CKB | 1152 | 21 | 4 | 28 | |
| GSE60625 | CKB | 1152 | 0 | 2 | 9 | |
| GSE74703 | CKB | 1152 | 5 | 3 | 28 | |
| GSE74704 | CKB | 1152 | 5 | 2 | 13 | |
| TCGA | CKB | 1152 | 31 | 20 | 45 |
Total number of gains: 122; Total number of losses: 60; Total Number of normals: 306.
Somatic mutations of CKB:
Generating mutation plots.
Highly correlated genes for CKB:
Showing top 20/563 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CKB | RNASE4 | 0.774029 | 4 | 0 | 4 |
| CKB | COA5 | 0.764405 | 3 | 0 | 3 |
| CKB | BCL6 | 0.759739 | 3 | 0 | 3 |
| CKB | IMMP2L | 0.728529 | 3 | 0 | 3 |
| CKB | FNDC5 | 0.727597 | 4 | 0 | 3 |
| CKB | DDIT3 | 0.725607 | 4 | 0 | 4 |
| CKB | CADM2 | 0.71678 | 4 | 0 | 3 |
| CKB | PDK2 | 0.712692 | 3 | 0 | 3 |
| CKB | RASSF3 | 0.710941 | 4 | 0 | 3 |
| CKB | MAOB | 0.70692 | 5 | 0 | 4 |
| CKB | SYNC | 0.70564 | 6 | 0 | 4 |
| CKB | RNF115 | 0.705414 | 4 | 0 | 3 |
| CKB | BVES | 0.703902 | 5 | 0 | 5 |
| CKB | MECP2 | 0.703372 | 5 | 0 | 5 |
| CKB | TACR2 | 0.70199 | 8 | 0 | 7 |
| CKB | LIN7A | 0.69931 | 3 | 0 | 3 |
| CKB | LRCH2 | 0.698856 | 4 | 0 | 3 |
| CKB | SPRYD3 | 0.698598 | 3 | 0 | 3 |
| CKB | NES | 0.696348 | 3 | 0 | 3 |
| CKB | FGF12 | 0.69335 | 4 | 0 | 3 |
For details and further investigation, click here
