| Full name: THO complex 1 | Alias Symbol: P84|HPR1 | ||
| Type: protein-coding gene | Cytoband: 18p11.32 | ||
| Entrez ID: 9984 | HGNC ID: HGNC:19070 | Ensembl Gene: ENSG00000079134 | OMIM ID: 606930 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of THOC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | THOC1 | 9984 | 204064_at | 0.1605 | 0.8540 | |
| GSE20347 | THOC1 | 9984 | 204064_at | 0.5433 | 0.0000 | |
| GSE23400 | THOC1 | 9984 | 204064_at | 0.2371 | 0.0000 | |
| GSE26886 | THOC1 | 9984 | 204064_at | 0.0037 | 0.9899 | |
| GSE29001 | THOC1 | 9984 | 204064_at | 0.4900 | 0.0260 | |
| GSE38129 | THOC1 | 9984 | 204064_at | 0.4004 | 0.0024 | |
| GSE45670 | THOC1 | 9984 | 204064_at | 0.3398 | 0.0178 | |
| GSE53622 | THOC1 | 9984 | 143372 | 0.3882 | 0.0000 | |
| GSE53624 | THOC1 | 9984 | 143372 | 0.3274 | 0.0000 | |
| GSE63941 | THOC1 | 9984 | 204064_at | 0.7439 | 0.1471 | |
| GSE77861 | THOC1 | 9984 | 204064_at | 0.3837 | 0.0660 | |
| GSE97050 | THOC1 | 9984 | A_23_P78372 | 0.2088 | 0.5419 | |
| SRP007169 | THOC1 | 9984 | RNAseq | 0.8170 | 0.0933 | |
| SRP008496 | THOC1 | 9984 | RNAseq | 1.4667 | 0.0006 | |
| SRP064894 | THOC1 | 9984 | RNAseq | 0.6718 | 0.0141 | |
| SRP133303 | THOC1 | 9984 | RNAseq | 0.4210 | 0.0041 | |
| SRP159526 | THOC1 | 9984 | RNAseq | 0.4673 | 0.1976 | |
| SRP193095 | THOC1 | 9984 | RNAseq | 0.2669 | 0.0245 | |
| SRP219564 | THOC1 | 9984 | RNAseq | 0.2506 | 0.4958 | |
| TCGA | THOC1 | 9984 | RNAseq | 0.1440 | 0.0376 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by THOC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of THOC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | THOC1 | 9984 | 6 | 4 | 20 | |
| GSE20123 | THOC1 | 9984 | 6 | 4 | 20 | |
| GSE43470 | THOC1 | 9984 | 1 | 5 | 37 | |
| GSE46452 | THOC1 | 9984 | 4 | 20 | 35 | |
| GSE47630 | THOC1 | 9984 | 7 | 18 | 15 | |
| GSE54993 | THOC1 | 9984 | 6 | 3 | 61 | |
| GSE54994 | THOC1 | 9984 | 11 | 8 | 34 | |
| GSE60625 | THOC1 | 9984 | 0 | 4 | 7 | |
| GSE74703 | THOC1 | 9984 | 1 | 2 | 33 | |
| GSE74704 | THOC1 | 9984 | 4 | 2 | 14 | |
| TCGA | THOC1 | 9984 | 34 | 19 | 43 |
Total number of gains: 80; Total number of losses: 89; Total Number of normals: 319.
Somatic mutations of THOC1:
Generating mutation plots.
Highly correlated genes for THOC1:
Showing top 20/651 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| THOC1 | MRPS5 | 0.812964 | 3 | 0 | 3 |
| THOC1 | GNAI1 | 0.788207 | 3 | 0 | 3 |
| THOC1 | NOM1 | 0.77303 | 3 | 0 | 3 |
| THOC1 | ERRFI1 | 0.751926 | 3 | 0 | 3 |
| THOC1 | ZBED1 | 0.747159 | 3 | 0 | 3 |
| THOC1 | ZXDC | 0.746126 | 4 | 0 | 3 |
| THOC1 | SCFD1 | 0.742188 | 3 | 0 | 3 |
| THOC1 | MRPL52 | 0.73641 | 4 | 0 | 4 |
| THOC1 | DDIT3 | 0.735535 | 3 | 0 | 3 |
| THOC1 | IL17RD | 0.735427 | 3 | 0 | 3 |
| THOC1 | TRA2A | 0.731117 | 3 | 0 | 3 |
| THOC1 | TPCN2 | 0.73092 | 4 | 0 | 3 |
| THOC1 | FAM20B | 0.719753 | 3 | 0 | 3 |
| THOC1 | NUDT9 | 0.717639 | 3 | 0 | 3 |
| THOC1 | MAP4K3 | 0.715181 | 4 | 0 | 3 |
| THOC1 | PPP1R35 | 0.714808 | 3 | 0 | 3 |
| THOC1 | INPP4A | 0.714757 | 4 | 0 | 4 |
| THOC1 | NPNT | 0.706022 | 3 | 0 | 3 |
| THOC1 | NEK3 | 0.704563 | 3 | 0 | 3 |
| THOC1 | SCCPDH | 0.701607 | 4 | 0 | 4 |
For details and further investigation, click here
