| Full name: epidermal growth factor receptor pathway substrate 8 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12p12.3 | ||
| Entrez ID: 2059 | HGNC ID: HGNC:3420 | Ensembl Gene: ENSG00000151491 | OMIM ID: 600206 |
| Drug and gene relationship at DGIdb | |||
Expression of EPS8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EPS8 | 2059 | 202609_at | -0.6238 | 0.4773 | |
| GSE20347 | EPS8 | 2059 | 202609_at | -0.3212 | 0.4221 | |
| GSE23400 | EPS8 | 2059 | 202609_at | 0.3677 | 0.0921 | |
| GSE26886 | EPS8 | 2059 | 202609_at | 0.7290 | 0.2511 | |
| GSE29001 | EPS8 | 2059 | 202609_at | -0.1336 | 0.8565 | |
| GSE38129 | EPS8 | 2059 | 202609_at | -0.1868 | 0.6273 | |
| GSE45670 | EPS8 | 2059 | 202609_at | -1.2192 | 0.0236 | |
| GSE53622 | EPS8 | 2059 | 109981 | -0.2375 | 0.0710 | |
| GSE53624 | EPS8 | 2059 | 109981 | -0.2225 | 0.1256 | |
| GSE63941 | EPS8 | 2059 | 202609_at | -1.1683 | 0.4133 | |
| GSE77861 | EPS8 | 2059 | 202609_at | 1.1492 | 0.0477 | |
| GSE97050 | EPS8 | 2059 | A_23_P136347 | -0.2434 | 0.4173 | |
| SRP007169 | EPS8 | 2059 | RNAseq | 1.4280 | 0.0334 | |
| SRP008496 | EPS8 | 2059 | RNAseq | 1.9401 | 0.0001 | |
| SRP064894 | EPS8 | 2059 | RNAseq | -0.1528 | 0.6441 | |
| SRP133303 | EPS8 | 2059 | RNAseq | 0.1861 | 0.4977 | |
| SRP159526 | EPS8 | 2059 | RNAseq | 0.3985 | 0.2968 | |
| SRP193095 | EPS8 | 2059 | RNAseq | -0.2855 | 0.4203 | |
| SRP219564 | EPS8 | 2059 | RNAseq | -0.0498 | 0.9342 | |
| TCGA | EPS8 | 2059 | RNAseq | -0.2866 | 0.0301 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by EPS8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EPS8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EPS8 | 2059 | 6 | 2 | 22 | |
| GSE20123 | EPS8 | 2059 | 6 | 2 | 22 | |
| GSE43470 | EPS8 | 2059 | 9 | 4 | 30 | |
| GSE46452 | EPS8 | 2059 | 10 | 1 | 48 | |
| GSE47630 | EPS8 | 2059 | 14 | 1 | 25 | |
| GSE54993 | EPS8 | 2059 | 1 | 9 | 60 | |
| GSE54994 | EPS8 | 2059 | 11 | 2 | 40 | |
| GSE60625 | EPS8 | 2059 | 0 | 1 | 10 | |
| GSE74703 | EPS8 | 2059 | 9 | 3 | 24 | |
| GSE74704 | EPS8 | 2059 | 4 | 1 | 15 | |
| TCGA | EPS8 | 2059 | 41 | 5 | 50 |
Total number of gains: 111; Total number of losses: 31; Total Number of normals: 346.
Somatic mutations of EPS8:
Generating mutation plots.
Highly correlated genes for EPS8:
Showing top 20/599 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EPS8 | DDHD1 | 0.789861 | 3 | 0 | 3 |
| EPS8 | ZNF202 | 0.78455 | 3 | 0 | 3 |
| EPS8 | CWF19L2 | 0.759862 | 3 | 0 | 3 |
| EPS8 | ING4 | 0.754527 | 3 | 0 | 3 |
| EPS8 | NCAPD2 | 0.750783 | 3 | 0 | 3 |
| EPS8 | KBTBD4 | 0.742187 | 3 | 0 | 3 |
| EPS8 | PNKD | 0.738327 | 3 | 0 | 3 |
| EPS8 | ABCB7 | 0.731884 | 3 | 0 | 3 |
| EPS8 | DHX57 | 0.730149 | 3 | 0 | 3 |
| EPS8 | CRKL | 0.720787 | 3 | 0 | 3 |
| EPS8 | C3orf70 | 0.71773 | 4 | 0 | 4 |
| EPS8 | DHRSX | 0.716197 | 3 | 0 | 3 |
| EPS8 | DDX50 | 0.715957 | 3 | 0 | 3 |
| EPS8 | EMCN | 0.715903 | 4 | 0 | 4 |
| EPS8 | ZNF260 | 0.714003 | 4 | 0 | 3 |
| EPS8 | ZNF3 | 0.71353 | 4 | 0 | 3 |
| EPS8 | MED30 | 0.713187 | 3 | 0 | 3 |
| EPS8 | AXL | 0.712754 | 5 | 0 | 5 |
| EPS8 | TNRC6C | 0.710677 | 3 | 0 | 3 |
| EPS8 | S1PR1 | 0.708697 | 5 | 0 | 4 |
For details and further investigation, click here
