ELAVL1

 

Full name: ELAV like RNA binding protein 1 Alias Symbol: HuR|Hua|MelG
Type: protein-coding gene Cytoband: 19p13.2
Entrez ID: 1994 HGNC ID: HGNC:3312 Ensembl Gene: ENSG00000066044 OMIM ID: 603466
Drug and gene relationship at DGIdb
Screen Evidence:

 

ELAVL1 involved pathways:

KEGG pathway Description View
hsa04152AMPK signaling pathway

 

Expression of ELAVL1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ELAVL1 1994 201726_at 0.5428 0.1007
GSE20347 ELAVL1 1994 201726_at 0.4230 0.0139
GSE23400 ELAVL1 1994 201726_at 0.5975 0.0000
GSE26886 ELAVL1 1994 201726_at -0.6238 0.0001
GSE29001 ELAVL1 1994 201726_at 0.4959 0.0812
GSE38129 ELAVL1 1994 201726_at 0.4822 0.0004
GSE45670 ELAVL1 1994 201726_at 0.2455 0.0115
GSE53622 ELAVL1 1994 17038 0.1501 0.0081
GSE53624 ELAVL1 1994 17038 0.4552 0.0000
GSE63941 ELAVL1 1994 201726_at 0.1667 0.5105
GSE77861 ELAVL1 1994 201726_at 0.4050 0.0257
GSE97050 ELAVL1 1994 A_23_P388681 0.1205 0.7234
SRP007169 ELAVL1 1994 RNAseq 0.9361 0.0056
SRP008496 ELAVL1 1994 RNAseq 1.0235 0.0000
SRP064894 ELAVL1 1994 RNAseq 0.4093 0.0011
SRP133303 ELAVL1 1994 RNAseq 0.3135 0.0246
SRP159526 ELAVL1 1994 RNAseq 0.5722 0.0016
SRP193095 ELAVL1 1994 RNAseq 0.3517 0.0000
SRP219564 ELAVL1 1994 RNAseq 0.5316 0.0493
TCGA ELAVL1 1994 RNAseq 0.1285 0.0046

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by ELAVL1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ELAVL1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ELAVL1 1994 4 3 23
GSE20123 ELAVL1 1994 3 2 25
GSE43470 ELAVL1 1994 2 7 34
GSE46452 ELAVL1 1994 47 1 11
GSE47630 ELAVL1 1994 5 7 28
GSE54993 ELAVL1 1994 16 3 51
GSE54994 ELAVL1 1994 6 14 33
GSE60625 ELAVL1 1994 9 0 2
GSE74703 ELAVL1 1994 2 4 30
GSE74704 ELAVL1 1994 0 2 18
TCGA ELAVL1 1994 10 20 66

Total number of gains: 104; Total number of losses: 63; Total Number of normals: 321.  

 

Somatic mutations of ELAVL1:

 

Generating mutation plots.

 

Highly correlated genes for ELAVL1:

 

Showing top 20/1134 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ELAVL1MRPL380.803069303
ELAVL1SYK0.792004303
ELAVL1HPS30.786973404
ELAVL1ARF30.776448303
ELAVL1AKT1S10.774951303
ELAVL1CWF19L10.773008303
ELAVL1ZNF3170.760221505
ELAVL1PRMT60.755115303
ELAVL1DNAJC90.750587707
ELAVL1ORAI10.748742404
ELAVL1RNPS10.748073707
ELAVL1CERS50.741755303
ELAVL1XPO10.734339909
ELAVL1ISY10.7262303
ELAVL1MRPL30.723814707
ELAVL1RSRC20.723074303
ELAVL1MSH60.7200421008
ELAVL1HMGN20.718765505
ELAVL1DDX500.712506606
ELAVL1TUBA1B0.712494907

For details and further investigation, click here