PSME4

 

Full name: proteasome activator subunit 4 Alias Symbol: PA200|KIAA0077
Type: protein-coding gene Cytoband: 2p16.2
Entrez ID: 23198 HGNC ID: HGNC:20635 Ensembl Gene: ENSG00000068878 OMIM ID: 607705
Drug and gene relationship at DGIdb

 

Expression of PSME4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PSME4 23198 212219_at 0.7107 0.0373
GSE20347 PSME4 23198 212219_at 0.9758 0.0000
GSE23400 PSME4 23198 212219_at 0.9703 0.0000
GSE26886 PSME4 23198 212219_at 0.9797 0.0000
GSE29001 PSME4 23198 212219_at 0.8005 0.0014
GSE38129 PSME4 23198 212219_at 1.0481 0.0000
GSE45670 PSME4 23198 212219_at 0.8718 0.0000
GSE53622 PSME4 23198 5522 0.9784 0.0000
GSE53624 PSME4 23198 5522 0.7906 0.0000
GSE63941 PSME4 23198 212219_at -0.2138 0.6127
GSE77861 PSME4 23198 212219_at 1.1411 0.0008
GSE97050 PSME4 23198 A_23_P79628 0.5898 0.1722
SRP007169 PSME4 23198 RNAseq 1.6026 0.0000
SRP008496 PSME4 23198 RNAseq 1.4536 0.0000
SRP064894 PSME4 23198 RNAseq 0.4643 0.0031
SRP133303 PSME4 23198 RNAseq 0.9639 0.0000
SRP159526 PSME4 23198 RNAseq 0.8551 0.0020
SRP193095 PSME4 23198 RNAseq 0.7126 0.0000
SRP219564 PSME4 23198 RNAseq 0.4141 0.2961
TCGA PSME4 23198 RNAseq 0.0824 0.0653

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by PSME4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PSME4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PSME4 23198 8 0 22
GSE20123 PSME4 23198 7 0 23
GSE43470 PSME4 23198 5 0 38
GSE46452 PSME4 23198 2 4 53
GSE47630 PSME4 23198 8 0 32
GSE54993 PSME4 23198 0 5 65
GSE54994 PSME4 23198 12 2 39
GSE60625 PSME4 23198 0 3 8
GSE74703 PSME4 23198 5 0 31
GSE74704 PSME4 23198 8 0 12
TCGA PSME4 23198 36 2 58

Total number of gains: 91; Total number of losses: 16; Total Number of normals: 381.  

 

Somatic mutations of PSME4:

 

Generating mutation plots.

 

Highly correlated genes for PSME4:

 

Showing top 20/2172 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PSME4CDCA20.804851505
PSME4BUB10.80424909
PSME4NUF20.801192707
PSME4ACTL6A0.79792711011
PSME4CMSS10.795895606
PSME4GMPS0.79392411011
PSME4ADAM170.79369911011
PSME4CAD0.79308411011
PSME4U2SURP0.78833909
PSME4SNRPG0.78786611011
PSME4TPX20.78500311011
PSME4HEATR10.78460611011
PSME4MTHFD20.78162411011
PSME4RUVBL10.78157311011
PSME4ECT20.78081111010
PSME4C1orf1310.780473707
PSME4TIMELESS0.77957411011
PSME4DKC10.77779303
PSME4KIF140.77748811011
PSME4CBX30.77665910010

For details and further investigation, click here