| Full name: optineurin | Alias Symbol: FIP2|HYPL|FIP-2|TFIIIA-INTP|NRP|HIP7 | ||
| Type: protein-coding gene | Cytoband: 10p13 | ||
| Entrez ID: 10133 | HGNC ID: HGNC:17142 | Ensembl Gene: ENSG00000123240 | OMIM ID: 602432 |
| Drug and gene relationship at DGIdb | |||
Expression of OPTN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OPTN | 10133 | 202074_s_at | -0.8035 | 0.1903 | |
| GSE20347 | OPTN | 10133 | 202074_s_at | -0.8856 | 0.0000 | |
| GSE23400 | OPTN | 10133 | 202074_s_at | -0.4105 | 0.0000 | |
| GSE26886 | OPTN | 10133 | 202074_s_at | -0.6165 | 0.0316 | |
| GSE29001 | OPTN | 10133 | 202074_s_at | -0.6901 | 0.0079 | |
| GSE38129 | OPTN | 10133 | 202074_s_at | -0.7019 | 0.0000 | |
| GSE45670 | OPTN | 10133 | 202074_s_at | -0.2427 | 0.2691 | |
| GSE53622 | OPTN | 10133 | 8098 | -0.6684 | 0.0000 | |
| GSE53624 | OPTN | 10133 | 8098 | -0.4808 | 0.0000 | |
| GSE63941 | OPTN | 10133 | 202074_s_at | -2.0558 | 0.0083 | |
| GSE77861 | OPTN | 10133 | 202074_s_at | -0.9725 | 0.0063 | |
| GSE97050 | OPTN | 10133 | A_33_P3333317 | -1.1104 | 0.0631 | |
| SRP007169 | OPTN | 10133 | RNAseq | -1.9273 | 0.0000 | |
| SRP008496 | OPTN | 10133 | RNAseq | -1.7257 | 0.0000 | |
| SRP064894 | OPTN | 10133 | RNAseq | -0.6464 | 0.0005 | |
| SRP133303 | OPTN | 10133 | RNAseq | -0.4004 | 0.0885 | |
| SRP159526 | OPTN | 10133 | RNAseq | -1.2309 | 0.0000 | |
| SRP193095 | OPTN | 10133 | RNAseq | -0.8220 | 0.0000 | |
| SRP219564 | OPTN | 10133 | RNAseq | -0.6368 | 0.1617 | |
| TCGA | OPTN | 10133 | RNAseq | -0.0843 | 0.1232 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by OPTN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OPTN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OPTN | 10133 | 6 | 7 | 17 | |
| GSE20123 | OPTN | 10133 | 6 | 6 | 18 | |
| GSE43470 | OPTN | 10133 | 3 | 5 | 35 | |
| GSE46452 | OPTN | 10133 | 2 | 14 | 43 | |
| GSE47630 | OPTN | 10133 | 6 | 14 | 20 | |
| GSE54993 | OPTN | 10133 | 11 | 1 | 58 | |
| GSE54994 | OPTN | 10133 | 4 | 9 | 40 | |
| GSE60625 | OPTN | 10133 | 0 | 0 | 11 | |
| GSE74703 | OPTN | 10133 | 2 | 3 | 31 | |
| GSE74704 | OPTN | 10133 | 1 | 5 | 14 | |
| TCGA | OPTN | 10133 | 21 | 24 | 51 |
Total number of gains: 62; Total number of losses: 88; Total Number of normals: 338.
Somatic mutations of OPTN:
Generating mutation plots.
Highly correlated genes for OPTN:
Showing top 20/1176 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OPTN | RARS2 | 0.790528 | 3 | 0 | 3 |
| OPTN | EVC2 | 0.771793 | 3 | 0 | 3 |
| OPTN | AGTR1 | 0.766416 | 3 | 0 | 3 |
| OPTN | NLGN4Y | 0.762542 | 3 | 0 | 3 |
| OPTN | ZNF615 | 0.758895 | 3 | 0 | 3 |
| OPTN | GPBP1 | 0.757205 | 4 | 0 | 4 |
| OPTN | TMEM38A | 0.742441 | 3 | 0 | 3 |
| OPTN | RGMB | 0.74005 | 3 | 0 | 3 |
| OPTN | FNIP1 | 0.739752 | 3 | 0 | 3 |
| OPTN | PRICKLE2 | 0.738205 | 4 | 0 | 4 |
| OPTN | MAMDC4 | 0.737421 | 3 | 0 | 3 |
| OPTN | MRVI1 | 0.737077 | 4 | 0 | 4 |
| OPTN | MRPS36 | 0.736055 | 5 | 0 | 4 |
| OPTN | FGF7 | 0.734788 | 3 | 0 | 3 |
| OPTN | ARHGAP31 | 0.732995 | 3 | 0 | 3 |
| OPTN | ZFY | 0.731646 | 3 | 0 | 3 |
| OPTN | LDLRAD3 | 0.723243 | 3 | 0 | 3 |
| OPTN | FIBIN | 0.721596 | 3 | 0 | 3 |
| OPTN | PDZD11 | 0.720462 | 4 | 0 | 4 |
| OPTN | GNB4 | 0.718884 | 3 | 0 | 3 |
For details and further investigation, click here
