| Full name: acid sensing ion channel subunit 1 | Alias Symbol: BNaC2|hBNaC2 | ||
| Type: protein-coding gene | Cytoband: 12q13.12 | ||
| Entrez ID: 41 | HGNC ID: HGNC:100 | Ensembl Gene: ENSG00000110881 | OMIM ID: 602866 |
| Drug and gene relationship at DGIdb | |||
ASIC1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04750 | Inflammatory mediator regulation of TRP channels |
Expression of ASIC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ASIC1 | 41 | 205156_s_at | -0.2645 | 0.3653 | |
| GSE20347 | ASIC1 | 41 | 205156_s_at | 0.1793 | 0.1152 | |
| GSE23400 | ASIC1 | 41 | 205156_s_at | -0.0875 | 0.0349 | |
| GSE26886 | ASIC1 | 41 | 205156_s_at | 0.2253 | 0.0806 | |
| GSE29001 | ASIC1 | 41 | 205156_s_at | -0.0384 | 0.8875 | |
| GSE38129 | ASIC1 | 41 | 205156_s_at | -0.0661 | 0.5920 | |
| GSE45670 | ASIC1 | 41 | 205156_s_at | -0.1979 | 0.0455 | |
| GSE53622 | ASIC1 | 41 | 33243 | -0.0723 | 0.5298 | |
| GSE53624 | ASIC1 | 41 | 33243 | 0.3436 | 0.0000 | |
| GSE63941 | ASIC1 | 41 | 205156_s_at | 0.1111 | 0.7320 | |
| GSE77861 | ASIC1 | 41 | 205156_s_at | -0.0618 | 0.6213 | |
| SRP007169 | ASIC1 | 41 | RNAseq | 0.6732 | 0.2638 | |
| SRP064894 | ASIC1 | 41 | RNAseq | 0.5317 | 0.0233 | |
| SRP133303 | ASIC1 | 41 | RNAseq | -0.3631 | 0.2002 | |
| SRP159526 | ASIC1 | 41 | RNAseq | 0.4454 | 0.2155 | |
| SRP193095 | ASIC1 | 41 | RNAseq | 1.0050 | 0.0000 | |
| SRP219564 | ASIC1 | 41 | RNAseq | 0.2175 | 0.6561 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ASIC1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of ASIC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ASIC1 | 41 | 8 | 1 | 21 | |
| GSE20123 | ASIC1 | 41 | 8 | 1 | 21 | |
| GSE43470 | ASIC1 | 41 | 3 | 0 | 40 | |
| GSE46452 | ASIC1 | 41 | 8 | 1 | 50 | |
| GSE47630 | ASIC1 | 41 | 11 | 2 | 27 | |
| GSE54993 | ASIC1 | 41 | 0 | 5 | 65 | |
| GSE54994 | ASIC1 | 41 | 4 | 1 | 48 | |
| GSE60625 | ASIC1 | 41 | 0 | 0 | 11 | |
| GSE74703 | ASIC1 | 41 | 3 | 0 | 33 | |
| GSE74704 | ASIC1 | 41 | 5 | 1 | 14 | |
| TCGA | ASIC1 | 41 | 15 | 11 | 70 |
Total number of gains: 65; Total number of losses: 23; Total Number of normals: 400.
Somatic mutations of ASIC1:
Generating mutation plots.
Highly correlated genes for ASIC1:
Showing top 20/508 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ASIC1 | EDDM3A | 0.70584 | 4 | 0 | 4 |
| ASIC1 | CAV3 | 0.69374 | 3 | 0 | 3 |
| ASIC1 | USH1C | 0.676093 | 4 | 0 | 4 |
| ASIC1 | C11orf16 | 0.673381 | 5 | 0 | 5 |
| ASIC1 | KCNG1 | 0.668471 | 3 | 0 | 3 |
| ASIC1 | LIPF | 0.666358 | 3 | 0 | 3 |
| ASIC1 | CHRNA2 | 0.661843 | 6 | 0 | 5 |
| ASIC1 | OR11A1 | 0.65994 | 3 | 0 | 3 |
| ASIC1 | DEFA6 | 0.655111 | 5 | 0 | 5 |
| ASIC1 | GABRA1 | 0.649586 | 4 | 0 | 3 |
| ASIC1 | CA8 | 0.646816 | 4 | 0 | 4 |
| ASIC1 | CXCR5 | 0.646431 | 4 | 0 | 3 |
| ASIC1 | IL25 | 0.646019 | 5 | 0 | 4 |
| ASIC1 | PIGO | 0.641883 | 3 | 0 | 3 |
| ASIC1 | OVGP1 | 0.640505 | 4 | 0 | 3 |
| ASIC1 | ATOH1 | 0.63778 | 3 | 0 | 3 |
| ASIC1 | PRAMEF12 | 0.636885 | 4 | 0 | 4 |
| ASIC1 | IL1RAPL2 | 0.635617 | 3 | 0 | 3 |
| ASIC1 | LRRC46 | 0.634644 | 3 | 0 | 3 |
| ASIC1 | ITIH2 | 0.632801 | 3 | 0 | 3 |
For details and further investigation, click here
