| Full name: replication factor C subunit 4 | Alias Symbol: A1|RFC37 | ||
| Type: protein-coding gene | Cytoband: 3q27.3 | ||
| Entrez ID: 5984 | HGNC ID: HGNC:9972 | Ensembl Gene: ENSG00000163918 | OMIM ID: 102577 |
| Drug and gene relationship at DGIdb | |||
Expression of RFC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RFC4 | 5984 | 204023_at | 1.1952 | 0.0309 | |
| GSE20347 | RFC4 | 5984 | 204023_at | 2.1026 | 0.0000 | |
| GSE23400 | RFC4 | 5984 | 204023_at | 1.9045 | 0.0000 | |
| GSE26886 | RFC4 | 5984 | 204023_at | 1.1547 | 0.0004 | |
| GSE29001 | RFC4 | 5984 | 204023_at | 1.9970 | 0.0001 | |
| GSE38129 | RFC4 | 5984 | 204023_at | 2.1370 | 0.0000 | |
| GSE45670 | RFC4 | 5984 | 204023_at | 1.4315 | 0.0000 | |
| GSE53622 | RFC4 | 5984 | 95818 | 1.6675 | 0.0000 | |
| GSE53624 | RFC4 | 5984 | 95818 | 1.9902 | 0.0000 | |
| GSE63941 | RFC4 | 5984 | 204023_at | 2.9049 | 0.0000 | |
| GSE77861 | RFC4 | 5984 | 204023_at | 1.6421 | 0.0011 | |
| GSE97050 | RFC4 | 5984 | A_23_P18196 | 0.9747 | 0.1344 | |
| SRP007169 | RFC4 | 5984 | RNAseq | 2.3712 | 0.0000 | |
| SRP008496 | RFC4 | 5984 | RNAseq | 2.5315 | 0.0000 | |
| SRP064894 | RFC4 | 5984 | RNAseq | 1.9082 | 0.0000 | |
| SRP133303 | RFC4 | 5984 | RNAseq | 1.9497 | 0.0000 | |
| SRP159526 | RFC4 | 5984 | RNAseq | 2.1730 | 0.0000 | |
| SRP193095 | RFC4 | 5984 | RNAseq | 1.4158 | 0.0000 | |
| SRP219564 | RFC4 | 5984 | RNAseq | 1.5457 | 0.0012 | |
| TCGA | RFC4 | 5984 | RNAseq | 0.8327 | 0.0000 |
Upregulated datasets: 18; Downregulated datasets: 0.
Survival by RFC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RFC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RFC4 | 5984 | 24 | 0 | 6 | |
| GSE20123 | RFC4 | 5984 | 24 | 0 | 6 | |
| GSE43470 | RFC4 | 5984 | 23 | 0 | 20 | |
| GSE46452 | RFC4 | 5984 | 19 | 1 | 39 | |
| GSE47630 | RFC4 | 5984 | 27 | 2 | 11 | |
| GSE54993 | RFC4 | 5984 | 1 | 19 | 50 | |
| GSE54994 | RFC4 | 5984 | 40 | 0 | 13 | |
| GSE60625 | RFC4 | 5984 | 0 | 6 | 5 | |
| GSE74703 | RFC4 | 5984 | 20 | 0 | 16 | |
| GSE74704 | RFC4 | 5984 | 16 | 0 | 4 | |
| TCGA | RFC4 | 5984 | 77 | 0 | 19 |
Total number of gains: 271; Total number of losses: 28; Total Number of normals: 189.
Somatic mutations of RFC4:
Generating mutation plots.
Highly correlated genes for RFC4:
Showing top 20/1945 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RFC4 | MCM2 | 0.868435 | 13 | 0 | 13 |
| RFC4 | CKS1B | 0.850099 | 13 | 0 | 13 |
| RFC4 | ACTL6A | 0.847645 | 13 | 0 | 13 |
| RFC4 | ECT2 | 0.846739 | 13 | 0 | 13 |
| RFC4 | UBE2T | 0.841363 | 9 | 0 | 9 |
| RFC4 | RAD51AP1 | 0.837325 | 13 | 0 | 13 |
| RFC4 | KIF2C | 0.828633 | 12 | 0 | 12 |
| RFC4 | DTL | 0.827986 | 13 | 0 | 13 |
| RFC4 | MYBL2 | 0.827897 | 12 | 0 | 12 |
| RFC4 | MCM6 | 0.822389 | 13 | 0 | 12 |
| RFC4 | MSH6 | 0.818007 | 12 | 0 | 12 |
| RFC4 | CBX3 | 0.817672 | 11 | 0 | 11 |
| RFC4 | NCAPH | 0.817653 | 9 | 0 | 9 |
| RFC4 | POLR2H | 0.815814 | 13 | 0 | 13 |
| RFC4 | CDC6 | 0.814688 | 9 | 0 | 9 |
| RFC4 | NEK2 | 0.81365 | 13 | 0 | 13 |
| RFC4 | CDK1 | 0.813639 | 12 | 0 | 11 |
| RFC4 | GINS1 | 0.813553 | 12 | 0 | 12 |
| RFC4 | MCM7 | 0.812075 | 13 | 0 | 13 |
| RFC4 | CENPF | 0.811763 | 13 | 0 | 13 |
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