GMNN

 

Full name: geminin DNA replication inhibitor Alias Symbol: Gem
Type: protein-coding gene Cytoband: 6p22.3
Entrez ID: 51053 HGNC ID: HGNC:17493 Ensembl Gene: ENSG00000112312 OMIM ID: 602842
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of GMNN:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GMNN 51053 218350_s_at 1.0360 0.0070
GSE20347 GMNN 51053 218350_s_at 1.4478 0.0000
GSE23400 GMNN 51053 218350_s_at 1.4812 0.0000
GSE26886 GMNN 51053 218350_s_at 1.6382 0.0000
GSE29001 GMNN 51053 218350_s_at 1.2826 0.0034
GSE38129 GMNN 51053 218350_s_at 1.5362 0.0000
GSE45670 GMNN 51053 218350_s_at 1.0328 0.0000
GSE53622 GMNN 51053 38300 1.0354 0.0000
GSE53624 GMNN 51053 38300 1.3957 0.0000
GSE63941 GMNN 51053 218350_s_at 2.0986 0.0008
GSE77861 GMNN 51053 218350_s_at 0.9117 0.0305
GSE97050 GMNN 51053 A_23_P19712 0.9297 0.2102
SRP007169 GMNN 51053 RNAseq 1.4842 0.0000
SRP008496 GMNN 51053 RNAseq 1.1491 0.0001
SRP064894 GMNN 51053 RNAseq 1.4950 0.0000
SRP133303 GMNN 51053 RNAseq 1.2206 0.0000
SRP159526 GMNN 51053 RNAseq 0.8243 0.0016
SRP193095 GMNN 51053 RNAseq 0.5046 0.0019
SRP219564 GMNN 51053 RNAseq 1.2579 0.0087
TCGA GMNN 51053 RNAseq 0.3566 0.0000

Upregulated datasets: 15; Downregulated datasets: 0.  

 

Survival by GMNN expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GMNN:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GMNN 51053 4 2 24
GSE20123 GMNN 51053 4 2 24
GSE43470 GMNN 51053 5 0 38
GSE46452 GMNN 51053 1 9 49
GSE47630 GMNN 51053 8 5 27
GSE54993 GMNN 51053 1 1 68
GSE54994 GMNN 51053 10 4 39
GSE60625 GMNN 51053 0 1 10
GSE74703 GMNN 51053 5 0 31
GSE74704 GMNN 51053 1 1 18
TCGA GMNN 51053 16 20 60

Total number of gains: 55; Total number of losses: 45; Total Number of normals: 388.  

 

Somatic mutations of GMNN:

 

Generating mutation plots.

 

Highly correlated genes for GMNN:

 

Showing top 20/2058 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GMNNDTL0.84839513013
GMNNCENPF0.84049412012
GMNNMCM60.835813013
GMNNCEP550.82734912012
GMNNXPO50.824247707
GMNNMMS22L0.823738303
GMNNKIF150.82157511011
GMNNRACGAP10.82007711011
GMNNFBXO50.81383612012
GMNNGINS10.8124912012
GMNNCCNB20.81213512012
GMNNDLGAP50.80643212012
GMNNASPM0.80532413012
GMNNUBE2T0.802723909
GMNNRFC40.8027113013
GMNNTPX20.80146613013
GMNNCBX30.80133810010
GMNNEXO10.80012912012
GMNNCKS20.79960412012
GMNNSPAG50.79948413013

For details and further investigation, click here