XPO1

 

Full name: exportin 1 Alias Symbol: CRM1|CRM-1|emb
Type: protein-coding gene Cytoband: 2p15
Entrez ID: 7514 HGNC ID: HGNC:12825 Ensembl Gene: ENSG00000082898 OMIM ID: 602559
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 231/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of XPO1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 XPO1 7514 208775_at 0.6797 0.1511
GSE20347 XPO1 7514 208775_at 0.7096 0.0000
GSE23400 XPO1 7514 208775_at 0.7841 0.0000
GSE26886 XPO1 7514 208775_at 0.0283 0.8953
GSE29001 XPO1 7514 208775_at 0.6161 0.0031
GSE38129 XPO1 7514 208775_at 0.6801 0.0000
GSE45670 XPO1 7514 208775_at 0.3223 0.0146
GSE53622 XPO1 7514 86201 0.7720 0.0000
GSE53624 XPO1 7514 86201 0.8005 0.0000
GSE63941 XPO1 7514 208775_at 0.6194 0.0408
GSE77861 XPO1 7514 208775_at 0.5623 0.0072
GSE97050 XPO1 7514 A_23_P40078 0.6723 0.0740
SRP007169 XPO1 7514 RNAseq 0.9567 0.0020
SRP008496 XPO1 7514 RNAseq 0.9303 0.0000
SRP064894 XPO1 7514 RNAseq 0.4809 0.0047
SRP133303 XPO1 7514 RNAseq 0.7793 0.0000
SRP159526 XPO1 7514 RNAseq 0.7952 0.0001
SRP193095 XPO1 7514 RNAseq 0.4038 0.0000
SRP219564 XPO1 7514 RNAseq 0.4599 0.0761
TCGA XPO1 7514 RNAseq 0.2335 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by XPO1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of XPO1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 XPO1 7514 12 0 18
GSE20123 XPO1 7514 11 0 19
GSE43470 XPO1 7514 7 0 36
GSE46452 XPO1 7514 2 3 54
GSE47630 XPO1 7514 8 0 32
GSE54993 XPO1 7514 0 6 64
GSE54994 XPO1 7514 12 0 41
GSE60625 XPO1 7514 0 3 8
GSE74703 XPO1 7514 7 0 29
GSE74704 XPO1 7514 10 0 10
TCGA XPO1 7514 37 2 57

Total number of gains: 106; Total number of losses: 14; Total Number of normals: 368.  

 

Somatic mutations of XPO1:

 

Generating mutation plots.

 

Highly correlated genes for XPO1:

 

Showing top 20/2146 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
XPO1RAD180.84074303
XPO1MCM60.81447111011
XPO1PYCR20.813164303
XPO1BCL7C0.802321303
XPO1MSH60.78778913012
XPO1CDCA30.7856611009
XPO1MMS22L0.779627303
XPO1CAD0.77901511011
XPO1PTCD10.776541303
XPO1MED140.774117303
XPO1RAB340.772046303
XPO1TTL0.771998606
XPO1SCNM10.768786303
XPO1GORAB0.766885707
XPO1DTYMK0.76496910010
XPO1ZNF3430.764051303
XPO1CCT40.76315713012
XPO1DESI20.761975909
XPO1FMNL20.759584505
XPO1STARD70.75949812012

For details and further investigation, click here