| Full name: minichromosome maintenance complex component 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p12.2 | ||
| Entrez ID: 4172 | HGNC ID: HGNC:6945 | Ensembl Gene: ENSG00000112118 | OMIM ID: 602693 |
| Drug and gene relationship at DGIdb | |||
MCM3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle |
Expression of MCM3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MCM3 | 4172 | 201555_at | 0.9056 | 0.0124 | |
| GSE20347 | MCM3 | 4172 | 201555_at | 1.0855 | 0.0000 | |
| GSE23400 | MCM3 | 4172 | 201555_at | 1.1232 | 0.0000 | |
| GSE26886 | MCM3 | 4172 | 201555_at | -0.4016 | 0.1000 | |
| GSE29001 | MCM3 | 4172 | 201555_at | 1.0483 | 0.0004 | |
| GSE38129 | MCM3 | 4172 | 201555_at | 1.1289 | 0.0000 | |
| GSE45670 | MCM3 | 4172 | 201555_at | 0.7129 | 0.0015 | |
| GSE53622 | MCM3 | 4172 | 41589 | 0.6503 | 0.0000 | |
| GSE53624 | MCM3 | 4172 | 41589 | 1.0233 | 0.0000 | |
| GSE63941 | MCM3 | 4172 | 201555_at | 2.4755 | 0.0003 | |
| GSE77861 | MCM3 | 4172 | 201555_at | 0.8243 | 0.0085 | |
| GSE97050 | MCM3 | 4172 | A_23_P7873 | 0.4395 | 0.1927 | |
| SRP007169 | MCM3 | 4172 | RNAseq | 2.5796 | 0.0000 | |
| SRP008496 | MCM3 | 4172 | RNAseq | 2.1593 | 0.0000 | |
| SRP064894 | MCM3 | 4172 | RNAseq | 1.0770 | 0.0000 | |
| SRP133303 | MCM3 | 4172 | RNAseq | 0.8340 | 0.0002 | |
| SRP159526 | MCM3 | 4172 | RNAseq | 1.0579 | 0.0030 | |
| SRP193095 | MCM3 | 4172 | RNAseq | 0.7545 | 0.0000 | |
| SRP219564 | MCM3 | 4172 | RNAseq | 1.4284 | 0.0002 | |
| TCGA | MCM3 | 4172 | RNAseq | 0.3014 | 0.0000 |
Upregulated datasets: 11; Downregulated datasets: 0.
Survival by MCM3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MCM3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MCM3 | 4172 | 7 | 2 | 21 | |
| GSE20123 | MCM3 | 4172 | 8 | 2 | 20 | |
| GSE43470 | MCM3 | 4172 | 5 | 0 | 38 | |
| GSE46452 | MCM3 | 4172 | 3 | 10 | 46 | |
| GSE47630 | MCM3 | 4172 | 7 | 5 | 28 | |
| GSE54993 | MCM3 | 4172 | 3 | 1 | 66 | |
| GSE54994 | MCM3 | 4172 | 8 | 4 | 41 | |
| GSE60625 | MCM3 | 4172 | 0 | 3 | 8 | |
| GSE74703 | MCM3 | 4172 | 5 | 0 | 31 | |
| GSE74704 | MCM3 | 4172 | 4 | 1 | 15 | |
| TCGA | MCM3 | 4172 | 22 | 13 | 61 |
Total number of gains: 72; Total number of losses: 41; Total Number of normals: 375.
Somatic mutations of MCM3:
Generating mutation plots.
Highly correlated genes for MCM3:
Showing top 20/1579 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MCM3 | MCM6 | 0.841136 | 12 | 0 | 12 |
| MCM3 | MSH6 | 0.840007 | 12 | 0 | 12 |
| MCM3 | DNMT1 | 0.808377 | 12 | 0 | 12 |
| MCM3 | GMNN | 0.794221 | 12 | 0 | 12 |
| MCM3 | MCM7 | 0.792635 | 11 | 0 | 11 |
| MCM3 | RAD51AP1 | 0.782277 | 11 | 0 | 11 |
| MCM3 | CD276 | 0.780046 | 3 | 0 | 3 |
| MCM3 | TIMELESS | 0.776648 | 12 | 0 | 12 |
| MCM3 | KIF2C | 0.77651 | 10 | 0 | 10 |
| MCM3 | C1orf112 | 0.773538 | 10 | 0 | 10 |
| MCM3 | SORL1 | 0.77237 | 3 | 0 | 3 |
| MCM3 | SNRPE | 0.771839 | 11 | 0 | 11 |
| MCM3 | HSPD1 | 0.769573 | 11 | 0 | 10 |
| MCM3 | KNTC1 | 0.769232 | 12 | 0 | 12 |
| MCM3 | CENPF | 0.768021 | 12 | 0 | 12 |
| MCM3 | RPA1 | 0.767285 | 11 | 0 | 11 |
| MCM3 | MARCKSL1 | 0.767276 | 10 | 0 | 10 |
| MCM3 | RFC4 | 0.766196 | 12 | 0 | 11 |
| MCM3 | SCNM1 | 0.76493 | 3 | 0 | 3 |
| MCM3 | MCM5 | 0.764293 | 10 | 0 | 9 |
For details and further investigation, click here
