DAZAP1

 

Full name: DAZ associated protein 1 Alias Symbol: MGC19907
Type: protein-coding gene Cytoband: 19p13.3
Entrez ID: 26528 HGNC ID: HGNC:2683 Ensembl Gene: ENSG00000071626 OMIM ID: 607430
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of DAZAP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DAZAP1 26528 226620_x_at 0.1238 0.7350
GSE20347 DAZAP1 26528 218443_s_at 0.2675 0.0087
GSE23400 DAZAP1 26528 218443_s_at 0.3487 0.0000
GSE26886 DAZAP1 26528 226620_x_at 0.1735 0.1967
GSE29001 DAZAP1 26528 218443_s_at 0.1800 0.3536
GSE38129 DAZAP1 26528 218443_s_at 0.2633 0.0091
GSE45670 DAZAP1 26528 226620_x_at 0.1910 0.0742
GSE53622 DAZAP1 26528 111985 -0.0029 0.9682
GSE53624 DAZAP1 26528 111985 0.3061 0.0000
GSE63941 DAZAP1 26528 226620_x_at 0.1767 0.5082
GSE77861 DAZAP1 26528 226620_x_at 0.2426 0.1572
GSE97050 DAZAP1 26528 A_23_P165247 0.2042 0.4877
SRP007169 DAZAP1 26528 RNAseq -0.2369 0.4871
SRP008496 DAZAP1 26528 RNAseq -0.2806 0.2284
SRP064894 DAZAP1 26528 RNAseq 0.3646 0.0465
SRP133303 DAZAP1 26528 RNAseq 0.1881 0.1619
SRP159526 DAZAP1 26528 RNAseq 0.1242 0.4605
SRP193095 DAZAP1 26528 RNAseq 0.1173 0.2443
SRP219564 DAZAP1 26528 RNAseq 0.2373 0.3668
TCGA DAZAP1 26528 RNAseq 0.1745 0.0002

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by DAZAP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DAZAP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DAZAP1 26528 4 6 20
GSE20123 DAZAP1 26528 4 5 21
GSE43470 DAZAP1 26528 1 11 31
GSE46452 DAZAP1 26528 47 1 11
GSE47630 DAZAP1 26528 5 7 28
GSE54993 DAZAP1 26528 16 3 51
GSE54994 DAZAP1 26528 8 15 30
GSE60625 DAZAP1 26528 9 0 2
GSE74703 DAZAP1 26528 1 8 27
GSE74704 DAZAP1 26528 3 3 14
TCGA DAZAP1 26528 7 25 64

Total number of gains: 105; Total number of losses: 84; Total Number of normals: 299.  

 

Somatic mutations of DAZAP1:

 

Generating mutation plots.

 

Highly correlated genes for DAZAP1:

 

Showing top 20/623 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DAZAP1PPHLN10.79194303
DAZAP1PPIL10.770526303
DAZAP1MIEN10.75972303
DAZAP1GTF2IRD10.750176303
DAZAP1USP240.745349303
DAZAP1DEK0.744727303
DAZAP1LARP1B0.74309303
DAZAP1SMAD10.737964303
DAZAP1C9orf640.730525303
DAZAP1MIS18BP10.725727303
DAZAP1RBBP70.724095303
DAZAP1MED220.724075303
DAZAP1RBM260.718649303
DAZAP1IRF2BPL0.716692303
DAZAP1SARS20.713212403
DAZAP1USP10.708917404
DAZAP1ARF30.708392303
DAZAP1NUDT190.705104403
DAZAP1TMTC40.70196303
DAZAP1RPA20.70124303

For details and further investigation, click here