| Full name: anaphase promoting complex subunit 1 | Alias Symbol: MCPR|TSG24|APC1 | ||
| Type: protein-coding gene | Cytoband: 2q13 | ||
| Entrez ID: 64682 | HGNC ID: HGNC:19988 | Ensembl Gene: ENSG00000153107 | OMIM ID: 608473 |
| Drug and gene relationship at DGIdb | |||
ANAPC1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle | |
| hsa04114 | Oocyte meiosis | |
| hsa04914 | Progesterone-mediated oocyte maturation | |
| hsa05166 | HTLV-I infection |
Expression of ANAPC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | ANAPC1 | 64682 | 11386 | 0.4816 | 0.0000 | |
| GSE53624 | ANAPC1 | 64682 | 17557 | 0.6631 | 0.0000 | |
| GSE97050 | ANAPC1 | 64682 | A_24_P186346 | 0.2273 | 0.4660 | |
| SRP007169 | ANAPC1 | 64682 | RNAseq | 1.0669 | 0.0007 | |
| SRP008496 | ANAPC1 | 64682 | RNAseq | 1.1251 | 0.0000 | |
| SRP064894 | ANAPC1 | 64682 | RNAseq | 0.0643 | 0.7339 | |
| SRP133303 | ANAPC1 | 64682 | RNAseq | 0.3580 | 0.0369 | |
| SRP159526 | ANAPC1 | 64682 | RNAseq | 0.5130 | 0.0821 | |
| SRP193095 | ANAPC1 | 64682 | RNAseq | 0.1858 | 0.0617 | |
| SRP219564 | ANAPC1 | 64682 | RNAseq | -0.1146 | 0.5987 | |
| TCGA | ANAPC1 | 64682 | RNAseq | 0.1288 | 0.0305 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ANAPC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ANAPC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ANAPC1 | 64682 | 5 | 2 | 23 | |
| GSE20123 | ANAPC1 | 64682 | 5 | 2 | 23 | |
| GSE43470 | ANAPC1 | 64682 | 3 | 1 | 39 | |
| GSE46452 | ANAPC1 | 64682 | 1 | 4 | 54 | |
| GSE47630 | ANAPC1 | 64682 | 7 | 0 | 33 | |
| GSE54993 | ANAPC1 | 64682 | 0 | 6 | 64 | |
| GSE54994 | ANAPC1 | 64682 | 10 | 0 | 43 | |
| GSE60625 | ANAPC1 | 64682 | 0 | 3 | 8 | |
| GSE74703 | ANAPC1 | 64682 | 3 | 1 | 32 | |
| GSE74704 | ANAPC1 | 64682 | 3 | 2 | 15 | |
| TCGA | ANAPC1 | 64682 | 31 | 5 | 60 |
Total number of gains: 68; Total number of losses: 26; Total Number of normals: 394.
Somatic mutations of ANAPC1:
Generating mutation plots.
Highly correlated genes for ANAPC1:
Showing top 20/362 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ANAPC1 | MIS18A | 0.78658 | 3 | 0 | 3 |
| ANAPC1 | MSH2 | 0.766176 | 3 | 0 | 3 |
| ANAPC1 | DTYMK | 0.765028 | 3 | 0 | 3 |
| ANAPC1 | PRPF40A | 0.765016 | 3 | 0 | 3 |
| ANAPC1 | RFC3 | 0.758934 | 3 | 0 | 3 |
| ANAPC1 | WDR54 | 0.757748 | 3 | 0 | 3 |
| ANAPC1 | DCAF13 | 0.75565 | 3 | 0 | 3 |
| ANAPC1 | CPSF6 | 0.753545 | 3 | 0 | 3 |
| ANAPC1 | DHFR | 0.752847 | 3 | 0 | 3 |
| ANAPC1 | HAT1 | 0.752075 | 3 | 0 | 3 |
| ANAPC1 | COG2 | 0.751851 | 3 | 0 | 3 |
| ANAPC1 | NUP88 | 0.751841 | 3 | 0 | 3 |
| ANAPC1 | NUP35 | 0.751775 | 3 | 0 | 3 |
| ANAPC1 | CEP85 | 0.750186 | 3 | 0 | 3 |
| ANAPC1 | YARS2 | 0.74972 | 3 | 0 | 3 |
| ANAPC1 | RFC2 | 0.748351 | 3 | 0 | 3 |
| ANAPC1 | DDX39A | 0.747969 | 3 | 0 | 3 |
| ANAPC1 | MRPL47 | 0.747656 | 3 | 0 | 3 |
| ANAPC1 | DNAJC2 | 0.744464 | 3 | 0 | 3 |
| ANAPC1 | FUS | 0.743784 | 3 | 0 | 3 |
For details and further investigation, click here
