| Full name: DENN domain containing 2A | Alias Symbol: FAM31D | ||
| Type: protein-coding gene | Cytoband: 7q34 | ||
| Entrez ID: 27147 | HGNC ID: HGNC:22212 | Ensembl Gene: ENSG00000146966 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of DENND2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DENND2A | 27147 | 53991_at | -0.6668 | 0.5254 | |
| GSE20347 | DENND2A | 27147 | 221885_at | -0.2160 | 0.0092 | |
| GSE23400 | DENND2A | 27147 | 53991_at | -0.2019 | 0.0005 | |
| GSE26886 | DENND2A | 27147 | 221885_at | 0.2600 | 0.1129 | |
| GSE29001 | DENND2A | 27147 | 53991_at | -0.2718 | 0.1024 | |
| GSE38129 | DENND2A | 27147 | 53991_at | -0.6809 | 0.0087 | |
| GSE45670 | DENND2A | 27147 | 53991_at | -0.7490 | 0.0046 | |
| GSE53622 | DENND2A | 27147 | 94409 | -0.9043 | 0.0000 | |
| GSE53624 | DENND2A | 27147 | 94409 | -0.5579 | 0.0000 | |
| GSE63941 | DENND2A | 27147 | 53991_at | -3.1670 | 0.0000 | |
| GSE77861 | DENND2A | 27147 | 221885_at | -0.1609 | 0.1014 | |
| GSE97050 | DENND2A | 27147 | A_23_P257583 | -0.7038 | 0.1745 | |
| SRP007169 | DENND2A | 27147 | RNAseq | 1.2988 | 0.1393 | |
| SRP064894 | DENND2A | 27147 | RNAseq | -0.3507 | 0.1458 | |
| SRP133303 | DENND2A | 27147 | RNAseq | -0.4114 | 0.1504 | |
| SRP159526 | DENND2A | 27147 | RNAseq | -0.0967 | 0.6418 | |
| SRP193095 | DENND2A | 27147 | RNAseq | 0.5153 | 0.0002 | |
| SRP219564 | DENND2A | 27147 | RNAseq | -0.7910 | 0.5028 | |
| TCGA | DENND2A | 27147 | RNAseq | -0.6968 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by DENND2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DENND2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DENND2A | 27147 | 5 | 2 | 23 | |
| GSE20123 | DENND2A | 27147 | 5 | 2 | 23 | |
| GSE43470 | DENND2A | 27147 | 2 | 4 | 37 | |
| GSE46452 | DENND2A | 27147 | 7 | 2 | 50 | |
| GSE47630 | DENND2A | 27147 | 7 | 4 | 29 | |
| GSE54993 | DENND2A | 27147 | 3 | 5 | 62 | |
| GSE54994 | DENND2A | 27147 | 5 | 8 | 40 | |
| GSE60625 | DENND2A | 27147 | 0 | 0 | 11 | |
| GSE74703 | DENND2A | 27147 | 2 | 4 | 30 | |
| GSE74704 | DENND2A | 27147 | 1 | 2 | 17 | |
| TCGA | DENND2A | 27147 | 28 | 23 | 45 |
Total number of gains: 65; Total number of losses: 56; Total Number of normals: 367.
Somatic mutations of DENND2A:
Generating mutation plots.
Highly correlated genes for DENND2A:
Showing top 20/767 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DENND2A | MGARP | 0.80139 | 3 | 0 | 3 |
| DENND2A | CORO6 | 0.778868 | 3 | 0 | 3 |
| DENND2A | BHMT2 | 0.77678 | 9 | 0 | 9 |
| DENND2A | MRGPRF | 0.774578 | 7 | 0 | 7 |
| DENND2A | LINC00702 | 0.76695 | 4 | 0 | 4 |
| DENND2A | ACTBL2 | 0.763406 | 3 | 0 | 3 |
| DENND2A | DACT3 | 0.76128 | 8 | 0 | 7 |
| DENND2A | FXYD1 | 0.758622 | 7 | 0 | 7 |
| DENND2A | NEGR1 | 0.746358 | 6 | 0 | 6 |
| DENND2A | UBXN10 | 0.745044 | 3 | 0 | 3 |
| DENND2A | ARHGAP6 | 0.743581 | 10 | 0 | 10 |
| DENND2A | PCDH9 | 0.740416 | 9 | 0 | 8 |
| DENND2A | PLP1 | 0.739684 | 9 | 0 | 9 |
| DENND2A | SLC35F1 | 0.738275 | 4 | 0 | 4 |
| DENND2A | CCDC69 | 0.736149 | 9 | 0 | 9 |
| DENND2A | PLA2G5 | 0.733639 | 8 | 0 | 8 |
| DENND2A | OSR1 | 0.733211 | 5 | 0 | 5 |
| DENND2A | JAM2 | 0.727948 | 10 | 0 | 10 |
| DENND2A | ADAMTSL1 | 0.725283 | 7 | 0 | 6 |
| DENND2A | PYGM | 0.724693 | 9 | 0 | 9 |
For details and further investigation, click here
