| Full name: DENN domain containing 2D | Alias Symbol: FLJ22457|RP5-1180E21.2 | ||
| Type: protein-coding gene | Cytoband: 1p13.3-p13.2 | ||
| Entrez ID: 79961 | HGNC ID: HGNC:26192 | Ensembl Gene: ENSG00000162777 | OMIM ID: 615111 |
| Drug and gene relationship at DGIdb | |||
Expression of DENND2D:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DENND2D | 79961 | 221081_s_at | -0.5219 | 0.5305 | |
| GSE20347 | DENND2D | 79961 | 221081_s_at | -1.6304 | 0.0000 | |
| GSE23400 | DENND2D | 79961 | 221081_s_at | -0.6014 | 0.0000 | |
| GSE26886 | DENND2D | 79961 | 221081_s_at | -2.0719 | 0.0000 | |
| GSE29001 | DENND2D | 79961 | 221081_s_at | -1.2302 | 0.0004 | |
| GSE38129 | DENND2D | 79961 | 221081_s_at | -1.0185 | 0.0002 | |
| GSE45670 | DENND2D | 79961 | 221081_s_at | -0.3324 | 0.2967 | |
| GSE53622 | DENND2D | 79961 | 26405 | -0.9666 | 0.0000 | |
| GSE53624 | DENND2D | 79961 | 26405 | -1.2301 | 0.0000 | |
| GSE63941 | DENND2D | 79961 | 221081_s_at | -0.3450 | 0.8141 | |
| GSE77861 | DENND2D | 79961 | 221081_s_at | -1.4241 | 0.0005 | |
| GSE97050 | DENND2D | 79961 | A_23_P85952 | 0.4578 | 0.4014 | |
| SRP007169 | DENND2D | 79961 | RNAseq | -1.5548 | 0.0007 | |
| SRP008496 | DENND2D | 79961 | RNAseq | -1.6450 | 0.0000 | |
| SRP064894 | DENND2D | 79961 | RNAseq | -1.0494 | 0.0000 | |
| SRP133303 | DENND2D | 79961 | RNAseq | -1.2639 | 0.0000 | |
| SRP159526 | DENND2D | 79961 | RNAseq | -1.8941 | 0.0000 | |
| SRP193095 | DENND2D | 79961 | RNAseq | -1.3481 | 0.0000 | |
| SRP219564 | DENND2D | 79961 | RNAseq | -1.0656 | 0.1707 | |
| TCGA | DENND2D | 79961 | RNAseq | -0.2074 | 0.0261 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by DENND2D expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DENND2D:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DENND2D | 79961 | 0 | 11 | 19 | |
| GSE20123 | DENND2D | 79961 | 0 | 11 | 19 | |
| GSE43470 | DENND2D | 79961 | 0 | 8 | 35 | |
| GSE46452 | DENND2D | 79961 | 2 | 1 | 56 | |
| GSE47630 | DENND2D | 79961 | 9 | 5 | 26 | |
| GSE54993 | DENND2D | 79961 | 0 | 1 | 69 | |
| GSE54994 | DENND2D | 79961 | 7 | 4 | 42 | |
| GSE60625 | DENND2D | 79961 | 0 | 0 | 11 | |
| GSE74703 | DENND2D | 79961 | 0 | 7 | 29 | |
| GSE74704 | DENND2D | 79961 | 0 | 7 | 13 | |
| TCGA | DENND2D | 79961 | 7 | 27 | 62 |
Total number of gains: 25; Total number of losses: 82; Total Number of normals: 381.
Somatic mutations of DENND2D:
Generating mutation plots.
Highly correlated genes for DENND2D:
Showing top 20/1537 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DENND2D | HDHD2 | 0.843792 | 3 | 0 | 3 |
| DENND2D | BLNK | 0.808148 | 11 | 0 | 10 |
| DENND2D | ZDHHC13 | 0.805494 | 11 | 0 | 11 |
| DENND2D | SFTA2 | 0.800329 | 4 | 0 | 4 |
| DENND2D | CXCR2 | 0.79696 | 10 | 0 | 10 |
| DENND2D | TTC39A | 0.792904 | 9 | 0 | 9 |
| DENND2D | SYTL1 | 0.792552 | 7 | 0 | 7 |
| DENND2D | ARHGAP27 | 0.787792 | 7 | 0 | 7 |
| DENND2D | EHF | 0.783462 | 11 | 0 | 11 |
| DENND2D | ALDH9A1 | 0.781272 | 10 | 0 | 10 |
| DENND2D | MPP7 | 0.776645 | 5 | 0 | 5 |
| DENND2D | MACC1 | 0.775448 | 7 | 0 | 6 |
| DENND2D | KLB | 0.772647 | 6 | 0 | 5 |
| DENND2D | CYSRT1 | 0.770566 | 6 | 0 | 6 |
| DENND2D | ZNF185 | 0.770562 | 10 | 0 | 10 |
| DENND2D | C5orf66-AS1 | 0.768652 | 6 | 0 | 5 |
| DENND2D | EPS8L2 | 0.768363 | 11 | 0 | 10 |
| DENND2D | ZC3H12D | 0.768058 | 3 | 0 | 3 |
| DENND2D | STX19 | 0.764679 | 6 | 0 | 6 |
| DENND2D | RAB25 | 0.763667 | 11 | 0 | 10 |
For details and further investigation, click here
