| Full name: klotho beta | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4p14 | ||
| Entrez ID: 152831 | HGNC ID: HGNC:15527 | Ensembl Gene: ENSG00000134962 | OMIM ID: 611135 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of KLB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLB | 152831 | 244276_at | -0.8891 | 0.1499 | |
| GSE26886 | KLB | 152831 | 244276_at | -2.8131 | 0.0000 | |
| GSE45670 | KLB | 152831 | 244276_at | -0.7500 | 0.1190 | |
| GSE53622 | KLB | 152831 | 54730 | -1.9334 | 0.0000 | |
| GSE53624 | KLB | 152831 | 54730 | -3.3146 | 0.0000 | |
| GSE63941 | KLB | 152831 | 244276_at | -0.2217 | 0.3294 | |
| GSE77861 | KLB | 152831 | 244276_at | -0.8289 | 0.0010 | |
| SRP007169 | KLB | 152831 | RNAseq | -2.1449 | 0.0000 | |
| SRP064894 | KLB | 152831 | RNAseq | -1.2053 | 0.0000 | |
| SRP133303 | KLB | 152831 | RNAseq | -0.7447 | 0.0004 | |
| SRP159526 | KLB | 152831 | RNAseq | -2.6666 | 0.0000 | |
| SRP193095 | KLB | 152831 | RNAseq | -0.6522 | 0.0000 | |
| TCGA | KLB | 152831 | RNAseq | -0.9837 | 0.0045 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by KLB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLB | 152831 | 0 | 16 | 14 | |
| GSE20123 | KLB | 152831 | 0 | 16 | 14 | |
| GSE43470 | KLB | 152831 | 0 | 15 | 28 | |
| GSE46452 | KLB | 152831 | 1 | 36 | 22 | |
| GSE47630 | KLB | 152831 | 1 | 19 | 20 | |
| GSE54993 | KLB | 152831 | 8 | 0 | 62 | |
| GSE54994 | KLB | 152831 | 3 | 10 | 40 | |
| GSE60625 | KLB | 152831 | 0 | 0 | 11 | |
| GSE74703 | KLB | 152831 | 0 | 12 | 24 | |
| GSE74704 | KLB | 152831 | 0 | 9 | 11 | |
| TCGA | KLB | 152831 | 10 | 45 | 41 |
Total number of gains: 23; Total number of losses: 178; Total Number of normals: 287.
Somatic mutations of KLB:
Generating mutation plots.
Highly correlated genes for KLB:
Showing top 20/1457 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLB | SFTA2 | 0.878666 | 4 | 0 | 4 |
| KLB | FAM3D | 0.878206 | 6 | 0 | 6 |
| KLB | SPNS2 | 0.86871 | 4 | 0 | 4 |
| KLB | GDPD3 | 0.868169 | 6 | 0 | 6 |
| KLB | ACPP | 0.852587 | 6 | 0 | 6 |
| KLB | SNORA68 | 0.850435 | 4 | 0 | 4 |
| KLB | SMAGP | 0.849784 | 6 | 0 | 6 |
| KLB | PHACTR4 | 0.84906 | 6 | 0 | 6 |
| KLB | C5orf66-AS1 | 0.845289 | 6 | 0 | 6 |
| KLB | TTC9 | 0.843664 | 6 | 0 | 6 |
| KLB | GBP6 | 0.842457 | 4 | 0 | 4 |
| KLB | PRSS2 | 0.841961 | 4 | 0 | 4 |
| KLB | KRT78 | 0.839441 | 6 | 0 | 6 |
| KLB | SLC16A6 | 0.838193 | 6 | 0 | 6 |
| KLB | SASH1 | 0.837143 | 6 | 0 | 6 |
| KLB | SMIM5 | 0.836108 | 6 | 0 | 6 |
| KLB | PCBP1-AS1 | 0.833912 | 3 | 0 | 3 |
| KLB | FAM3B | 0.833298 | 6 | 0 | 6 |
| KLB | FAM214A | 0.83315 | 6 | 0 | 6 |
| KLB | SCNN1B | 0.831614 | 6 | 0 | 6 |
For details and further investigation, click here
