| Full name: MET transcriptional regulator MACC1 | Alias Symbol: 7A5|SH3BP4L | ||
| Type: protein-coding gene | Cytoband: 7p21.1 | ||
| Entrez ID: 346389 | HGNC ID: HGNC:30215 | Ensembl Gene: ENSG00000183742 | OMIM ID: 612646 |
| Drug and gene relationship at DGIdb | |||
Expression of MACC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MACC1 | 346389 | 1566766_a_at | -0.4432 | 0.7321 | |
| GSE26886 | MACC1 | 346389 | 1566766_a_at | -2.0284 | 0.0000 | |
| GSE45670 | MACC1 | 346389 | 1566766_a_at | -0.4828 | 0.1918 | |
| GSE53622 | MACC1 | 346389 | 79277 | -1.4300 | 0.0000 | |
| GSE53624 | MACC1 | 346389 | 79277 | -2.2542 | 0.0000 | |
| GSE63941 | MACC1 | 346389 | 232151_at | 2.3862 | 0.0809 | |
| GSE77861 | MACC1 | 346389 | 1566766_a_at | -0.7584 | 0.0007 | |
| GSE97050 | MACC1 | 346389 | A_32_P131031 | 0.6034 | 0.5138 | |
| SRP007169 | MACC1 | 346389 | RNAseq | -2.3366 | 0.0010 | |
| SRP008496 | MACC1 | 346389 | RNAseq | -2.4377 | 0.0004 | |
| SRP064894 | MACC1 | 346389 | RNAseq | -2.6749 | 0.0000 | |
| SRP133303 | MACC1 | 346389 | RNAseq | -0.6908 | 0.1666 | |
| SRP159526 | MACC1 | 346389 | RNAseq | -3.1295 | 0.0000 | |
| SRP193095 | MACC1 | 346389 | RNAseq | -1.5589 | 0.0000 | |
| SRP219564 | MACC1 | 346389 | RNAseq | -2.8557 | 0.0020 | |
| TCGA | MACC1 | 346389 | RNAseq | -0.1507 | 0.4271 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by MACC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MACC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MACC1 | 346389 | 16 | 2 | 12 | |
| GSE20123 | MACC1 | 346389 | 16 | 2 | 12 | |
| GSE43470 | MACC1 | 346389 | 4 | 0 | 39 | |
| GSE46452 | MACC1 | 346389 | 10 | 2 | 47 | |
| GSE47630 | MACC1 | 346389 | 9 | 1 | 30 | |
| GSE54993 | MACC1 | 346389 | 0 | 6 | 64 | |
| GSE54994 | MACC1 | 346389 | 20 | 2 | 31 | |
| GSE60625 | MACC1 | 346389 | 0 | 0 | 11 | |
| GSE74703 | MACC1 | 346389 | 4 | 0 | 32 | |
| GSE74704 | MACC1 | 346389 | 10 | 2 | 8 | |
| TCGA | MACC1 | 346389 | 55 | 6 | 35 |
Total number of gains: 144; Total number of losses: 23; Total Number of normals: 321.
Somatic mutations of MACC1:
Generating mutation plots.
Highly correlated genes for MACC1:
Showing top 20/1276 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MACC1 | TMPRSS2 | 0.814859 | 6 | 0 | 6 |
| MACC1 | IKZF2 | 0.810835 | 8 | 0 | 8 |
| MACC1 | ARHGAP32 | 0.794383 | 7 | 0 | 7 |
| MACC1 | FUT3 | 0.792756 | 8 | 0 | 8 |
| MACC1 | TACSTD2 | 0.787703 | 8 | 0 | 8 |
| MACC1 | ARAP2 | 0.786481 | 3 | 0 | 3 |
| MACC1 | RBM47 | 0.785024 | 8 | 0 | 8 |
| MACC1 | EHF | 0.783255 | 7 | 0 | 7 |
| MACC1 | CYP3A5 | 0.782874 | 5 | 0 | 5 |
| MACC1 | FCHO2 | 0.780655 | 5 | 0 | 5 |
| MACC1 | RAB27B | 0.780317 | 7 | 0 | 7 |
| MACC1 | ZNF416 | 0.77993 | 4 | 0 | 4 |
| MACC1 | DENND2D | 0.775448 | 7 | 0 | 6 |
| MACC1 | GOLGA4 | 0.775225 | 3 | 0 | 3 |
| MACC1 | TMEM40 | 0.770321 | 7 | 0 | 7 |
| MACC1 | ELF3 | 0.766828 | 8 | 0 | 8 |
| MACC1 | FAM3B | 0.763398 | 6 | 0 | 6 |
| MACC1 | CLDN7 | 0.763231 | 8 | 0 | 8 |
| MACC1 | LLGL2 | 0.761907 | 7 | 0 | 7 |
| MACC1 | MAL2 | 0.760072 | 8 | 0 | 8 |
For details and further investigation, click here
