| Full name: DNA fragmentation factor subunit alpha | Alias Symbol: DFF-45|DFF45|ICAD|DFF1 | ||
| Type: protein-coding gene | Cytoband: 1p36.22 | ||
| Entrez ID: 1676 | HGNC ID: HGNC:2772 | Ensembl Gene: ENSG00000160049 | OMIM ID: 601882 |
| Drug and gene relationship at DGIdb | |||
DFFA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04210 | Apoptosis |
Expression of DFFA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DFFA | 1676 | 226116_at | 0.3119 | 0.3119 | |
| GSE20347 | DFFA | 1676 | 203277_at | 0.2952 | 0.0597 | |
| GSE23400 | DFFA | 1676 | 203277_at | 0.2707 | 0.0040 | |
| GSE26886 | DFFA | 1676 | 226116_at | 0.7096 | 0.0011 | |
| GSE29001 | DFFA | 1676 | 203277_at | 0.5467 | 0.0125 | |
| GSE38129 | DFFA | 1676 | 203277_at | 0.2768 | 0.0456 | |
| GSE45670 | DFFA | 1676 | 226116_at | 0.0243 | 0.8604 | |
| GSE53622 | DFFA | 1676 | 110237 | 0.3176 | 0.0000 | |
| GSE53624 | DFFA | 1676 | 110237 | 0.4516 | 0.0000 | |
| GSE63941 | DFFA | 1676 | 203277_at | 1.8874 | 0.0002 | |
| GSE77861 | DFFA | 1676 | 226116_at | 0.0927 | 0.7860 | |
| GSE97050 | DFFA | 1676 | A_23_P12189 | -0.0322 | 0.9220 | |
| SRP007169 | DFFA | 1676 | RNAseq | -0.0252 | 0.9490 | |
| SRP008496 | DFFA | 1676 | RNAseq | 0.0506 | 0.8662 | |
| SRP064894 | DFFA | 1676 | RNAseq | 0.3966 | 0.0397 | |
| SRP133303 | DFFA | 1676 | RNAseq | 0.1111 | 0.1412 | |
| SRP159526 | DFFA | 1676 | RNAseq | 0.1345 | 0.6626 | |
| SRP193095 | DFFA | 1676 | RNAseq | 0.0157 | 0.8599 | |
| SRP219564 | DFFA | 1676 | RNAseq | -0.1226 | 0.6498 | |
| TCGA | DFFA | 1676 | RNAseq | -0.0200 | 0.6880 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by DFFA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DFFA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DFFA | 1676 | 0 | 5 | 25 | |
| GSE20123 | DFFA | 1676 | 0 | 3 | 27 | |
| GSE43470 | DFFA | 1676 | 7 | 5 | 31 | |
| GSE46452 | DFFA | 1676 | 7 | 1 | 51 | |
| GSE47630 | DFFA | 1676 | 8 | 4 | 28 | |
| GSE54993 | DFFA | 1676 | 3 | 1 | 66 | |
| GSE54994 | DFFA | 1676 | 11 | 4 | 38 | |
| GSE60625 | DFFA | 1676 | 0 | 0 | 11 | |
| GSE74703 | DFFA | 1676 | 6 | 3 | 27 | |
| GSE74704 | DFFA | 1676 | 0 | 0 | 20 | |
| TCGA | DFFA | 1676 | 10 | 24 | 62 |
Total number of gains: 52; Total number of losses: 50; Total Number of normals: 386.
Somatic mutations of DFFA:
Generating mutation plots.
Highly correlated genes for DFFA:
Showing top 20/1087 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DFFA | GPATCH1 | 0.819983 | 3 | 0 | 3 |
| DFFA | ESCO1 | 0.810697 | 3 | 0 | 3 |
| DFFA | NAP1L4 | 0.794951 | 3 | 0 | 3 |
| DFFA | ZNF766 | 0.781796 | 3 | 0 | 3 |
| DFFA | ARID2 | 0.777729 | 3 | 0 | 3 |
| DFFA | DMTF1 | 0.773685 | 4 | 0 | 4 |
| DFFA | XAB2 | 0.772141 | 3 | 0 | 3 |
| DFFA | RFX7 | 0.769722 | 3 | 0 | 3 |
| DFFA | ANAPC5 | 0.765647 | 3 | 0 | 3 |
| DFFA | ALCAM | 0.76138 | 3 | 0 | 3 |
| DFFA | ZNF121 | 0.759289 | 4 | 0 | 4 |
| DFFA | ARL6IP4 | 0.758157 | 3 | 0 | 3 |
| DFFA | ZNF765 | 0.750702 | 3 | 0 | 3 |
| DFFA | CRTC2 | 0.748629 | 3 | 0 | 3 |
| DFFA | MED26 | 0.747759 | 3 | 0 | 3 |
| DFFA | ZNF140 | 0.746681 | 3 | 0 | 3 |
| DFFA | SENP1 | 0.74376 | 3 | 0 | 3 |
| DFFA | GATAD2B | 0.742011 | 3 | 0 | 3 |
| DFFA | ANKRD27 | 0.74191 | 3 | 0 | 3 |
| DFFA | ZBTB41 | 0.741636 | 3 | 0 | 3 |
For details and further investigation, click here
