NAP1L4

 

Full name: nucleosome assembly protein 1 like 4 Alias Symbol: NAP2
Type: protein-coding gene Cytoband: 11p15.4
Entrez ID: 4676 HGNC ID: HGNC:7640 Ensembl Gene: ENSG00000205531 OMIM ID: 601651
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of NAP1L4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NAP1L4 4676 201414_s_at 0.2514 0.3210
GSE20347 NAP1L4 4676 201414_s_at 0.1996 0.0762
GSE23400 NAP1L4 4676 201414_s_at 0.1532 0.0020
GSE26886 NAP1L4 4676 201414_s_at -0.2058 0.2309
GSE29001 NAP1L4 4676 201414_s_at 0.0484 0.9012
GSE38129 NAP1L4 4676 201414_s_at 0.2161 0.0225
GSE45670 NAP1L4 4676 201414_s_at 0.3542 0.0007
GSE53622 NAP1L4 4676 79350 -0.0819 0.1262
GSE53624 NAP1L4 4676 79350 0.1744 0.0030
GSE63941 NAP1L4 4676 1560339_s_at 1.5215 0.0004
GSE77861 NAP1L4 4676 1560339_s_at 0.3221 0.3227
GSE97050 NAP1L4 4676 A_24_P132950 -0.1373 0.6006
SRP007169 NAP1L4 4676 RNAseq 0.1083 0.7859
SRP008496 NAP1L4 4676 RNAseq 0.3928 0.0939
SRP064894 NAP1L4 4676 RNAseq 0.0642 0.6184
SRP133303 NAP1L4 4676 RNAseq 0.0898 0.3889
SRP159526 NAP1L4 4676 RNAseq -0.1690 0.2877
SRP193095 NAP1L4 4676 RNAseq -0.0235 0.8240
SRP219564 NAP1L4 4676 RNAseq 0.0968 0.7397
TCGA NAP1L4 4676 RNAseq 0.0755 0.0982

Upregulated datasets: 1; Downregulated datasets: 0.  


 

Survival by NAP1L4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of NAP1L4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NAP1L4 4676 1 11 18
GSE20123 NAP1L4 4676 1 12 17
GSE43470 NAP1L4 4676 1 10 32
GSE46452 NAP1L4 4676 7 8 44
GSE47630 NAP1L4 4676 4 12 24
GSE54993 NAP1L4 4676 3 1 66
GSE54994 NAP1L4 4676 1 12 40
GSE60625 NAP1L4 4676 0 0 11
GSE74703 NAP1L4 4676 1 8 27
GSE74704 NAP1L4 4676 0 8 12
TCGA NAP1L4 4676 7 40 49

Total number of gains: 26; Total number of losses: 122; Total Number of normals: 340.  


 

Somatic mutations of NAP1L4:

 

Generating mutation plots.

 

Highly correlated genes for NAP1L4:

 

Showing top 20/688 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NAP1L4DFFA0.794951303
NAP1L4MMS190.789502303
NAP1L4KLF130.768226404
NAP1L4NDUFV10.760717403
NAP1L4CCS0.755408303
NAP1L4SWAP700.75514303
NAP1L4SPSB20.75461303
NAP1L4MOB3C0.750276404
NAP1L4MAP3K130.749967303
NAP1L4INO80E0.747001403
NAP1L4SPTAN10.745352303
NAP1L4ZNF4960.73845303
NAP1L4SNX170.73807303
NAP1L4USP400.736146303
NAP1L4FAM168B0.731641404
NAP1L4RAVER10.723365303
NAP1L4NDUFB40.717631303
NAP1L4PARP140.715489303
NAP1L4VEGFB0.713594303
NAP1L4HSPB110.712591303

For details and further investigation, click here