| Full name: anaphase promoting complex subunit 5 | Alias Symbol: APC5 | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 51433 | HGNC ID: HGNC:15713 | Ensembl Gene: ENSG00000089053 | OMIM ID: 606948 |
| Drug and gene relationship at DGIdb | |||
ANAPC5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle | |
| hsa04114 | Oocyte meiosis | |
| hsa04914 | Progesterone-mediated oocyte maturation | |
| hsa05166 | HTLV-I infection |
Expression of ANAPC5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ANAPC5 | 51433 | 211036_x_at | 0.3904 | 0.3841 | |
| GSE20347 | ANAPC5 | 51433 | 211036_x_at | 0.2621 | 0.0410 | |
| GSE23400 | ANAPC5 | 51433 | 211036_x_at | 0.3961 | 0.0000 | |
| GSE26886 | ANAPC5 | 51433 | 211036_x_at | 0.7362 | 0.0000 | |
| GSE29001 | ANAPC5 | 51433 | 211036_x_at | 0.3680 | 0.0686 | |
| GSE38129 | ANAPC5 | 51433 | 211036_x_at | 0.2509 | 0.0043 | |
| GSE45670 | ANAPC5 | 51433 | 211036_x_at | 0.0896 | 0.4772 | |
| GSE53622 | ANAPC5 | 51433 | 95450 | 0.2480 | 0.0000 | |
| GSE53624 | ANAPC5 | 51433 | 95450 | 0.3084 | 0.0000 | |
| GSE63941 | ANAPC5 | 51433 | 211036_x_at | -0.0092 | 0.9757 | |
| GSE77861 | ANAPC5 | 51433 | 211036_x_at | -0.0025 | 0.9903 | |
| GSE97050 | ANAPC5 | 51433 | A_23_P204448 | 0.2561 | 0.2839 | |
| SRP007169 | ANAPC5 | 51433 | RNAseq | 1.1219 | 0.0281 | |
| SRP008496 | ANAPC5 | 51433 | RNAseq | 0.8540 | 0.0088 | |
| SRP064894 | ANAPC5 | 51433 | RNAseq | 0.2795 | 0.0006 | |
| SRP133303 | ANAPC5 | 51433 | RNAseq | 0.0744 | 0.5192 | |
| SRP159526 | ANAPC5 | 51433 | RNAseq | 0.2976 | 0.1345 | |
| SRP193095 | ANAPC5 | 51433 | RNAseq | 0.0446 | 0.5109 | |
| SRP219564 | ANAPC5 | 51433 | RNAseq | 0.0924 | 0.6778 | |
| TCGA | ANAPC5 | 51433 | RNAseq | 0.0097 | 0.8248 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ANAPC5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ANAPC5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ANAPC5 | 51433 | 5 | 4 | 21 | |
| GSE20123 | ANAPC5 | 51433 | 5 | 4 | 21 | |
| GSE43470 | ANAPC5 | 51433 | 2 | 2 | 39 | |
| GSE46452 | ANAPC5 | 51433 | 9 | 1 | 49 | |
| GSE47630 | ANAPC5 | 51433 | 9 | 3 | 28 | |
| GSE54993 | ANAPC5 | 51433 | 0 | 5 | 65 | |
| GSE54994 | ANAPC5 | 51433 | 6 | 7 | 40 | |
| GSE60625 | ANAPC5 | 51433 | 0 | 0 | 11 | |
| GSE74703 | ANAPC5 | 51433 | 2 | 1 | 33 | |
| GSE74704 | ANAPC5 | 51433 | 3 | 2 | 15 | |
| TCGA | ANAPC5 | 51433 | 21 | 10 | 65 |
Total number of gains: 62; Total number of losses: 39; Total Number of normals: 387.
Somatic mutations of ANAPC5:
Generating mutation plots.
Highly correlated genes for ANAPC5:
Showing top 20/1161 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ANAPC5 | RFNG | 0.864046 | 3 | 0 | 3 |
| ANAPC5 | RAVER1 | 0.840305 | 3 | 0 | 3 |
| ANAPC5 | FBXW8 | 0.809681 | 3 | 0 | 3 |
| ANAPC5 | LSP1 | 0.809373 | 3 | 0 | 3 |
| ANAPC5 | UBA52 | 0.798975 | 3 | 0 | 3 |
| ANAPC5 | C1orf122 | 0.793918 | 3 | 0 | 3 |
| ANAPC5 | MRPL38 | 0.770871 | 3 | 0 | 3 |
| ANAPC5 | SSBP4 | 0.770721 | 3 | 0 | 3 |
| ANAPC5 | TXLNG | 0.770524 | 3 | 0 | 3 |
| ANAPC5 | SYNGR3 | 0.767812 | 3 | 0 | 3 |
| ANAPC5 | DFFA | 0.765647 | 3 | 0 | 3 |
| ANAPC5 | ZNF484 | 0.75951 | 3 | 0 | 3 |
| ANAPC5 | CHCHD1 | 0.753683 | 3 | 0 | 3 |
| ANAPC5 | RUNDC1 | 0.753589 | 3 | 0 | 3 |
| ANAPC5 | CRTC2 | 0.751424 | 4 | 0 | 4 |
| ANAPC5 | RPS19BP1 | 0.749845 | 4 | 0 | 4 |
| ANAPC5 | VPS26B | 0.746472 | 3 | 0 | 3 |
| ANAPC5 | ZDHHC9 | 0.745341 | 3 | 0 | 3 |
| ANAPC5 | SENP5 | 0.740874 | 4 | 0 | 4 |
| ANAPC5 | PHC2 | 0.738118 | 3 | 0 | 3 |
For details and further investigation, click here
